Connexins in lymphatic vessel physiology and disease

FEBS Letters

Volumn 588, Issue 8, 2014, Pages 1271-1277

  Meens, Merlijn J ^a   Sabine, Amélie ^b,c   Petrova, Tatiana V ^b,c,d   Kwak, Brenda R ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d EPFL   (Switzerland)

Author keywords

Connexin; Endothelial cell; Gap junction; Lymphedema

Indexed keywords

CONNEXIN; ENDOTHELIAL CELL; GAP JUNCTION; LYMPHEDEMA;

ANIMALS; CONNEXINS; GAP JUNCTIONS; HUMANS; LYMPHATIC VESSELS; LYMPHEDEMA; MUTATION;

EID: 84898900766     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.01.011     Document Type: Conference Paper

References (60)

1. A. Pfenniger, A. Wohlwend, and B.R. Kwak Mutations in connexin genes and disease Eur. J. Clin. Invest. 41 2011 103 116
2. R. Dobrowolski, and K. Willecke Connexin-caused genetic diseases and corresponding mouse models Antioxid. Redox Signal. 11 2009 283 295
3. D.A. Goodenough, and D.L. Paul Beyond the gap: functions of unpaired connexon channels Nat. Rev. Mol. Cell Biol. 4 2003 285 294 (Pubitemid 36383955)
4. D. Bosco, J.A. Haefliger, and P. Meda Connexins: key mediators of endocrine function Physiol. Rev. 91 2011 1393 1445
5. R.C. Looft-Wilson, M. Billaud, S.R. Johnstone, A.C. Straub, and B.E. Isakson Interaction between nitric oxide signaling and gap junctions: effects on vascular function Biochim. Biophys. Acta 1818 2011 1895 1902
6. S. Verheule, and S. Kaese Connexin diversity in the heart: insights from transgenic mouse models Front. Pharmacol. 4 2013 81
7. M. Theis, and C. Giaume Connexin-based intercellular communication and astrocyte heterogeneity Brain Res. 1487 2012 88 98
8. A. Kurtz Renal connexins and blood pressure Biochim. Biophys. Acta 1818 2012 1903 1908
9. G. Sohl, S. Maxeiner, and K. Willecke Expression and functions of neuronal gap junctions Nat. Rev. Neurosci. 6 2005 191 200 (Pubitemid 40342414)
10. A. Sabine, Y. Agalarov, H. Maby-El Hajjami, M. Jaquet, R. Hagerling, and C. Pollmann et al. Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin 37 and calcineurin during lymphatic-valve formation Dev. Cell 22 2012 430 445
11. J.D. Kanady, M.T. Dellinger, S.J. Munger, M.H. Witte, and A.M. Simon Connexin 37 and Connexin 43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax Dev. Biol. 354 2011 253 266
12. E. Crivellato, L. Travan, and D. Ribatti The Hippocratic treatise 'On glands': the first document on lymphoid tissue and lymph nodes Leukemia 21 2007 591 592 (Pubitemid 46444538)
13. K. Alitalo The lymphatic vasculature in disease Nat. Med. 17 2011 1371 1380
14. S. Schulte-Merker, A. Sabine, and T.V. Petrova Lymphatic vascular morphogenesis in development, physiology, and disease J. Cell Biol. 193 2011 607 618
15. L.N. Cueni, and M. Detmar The lymphatic system in health and disease Lymphat. Res. Biol. 6 2008 109 122
16. J.M. Lauweryns, and L. Boussauw The ultrastructure of lymphatic valves in the adult rabbit lung Z. Zellforsch. Mikrosk. Anat. 143 1973 149 168
17. D.C. Zawieja Contractile physiology of lymphatics Lymphat. Res. Biol. 7 2009 87 96
18. J.P. Scallan, and M.J. Davis Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels J. Physiol. 591 2013 2139 2156
19. A. Alitalo, and M. Detmar Interaction of tumor cells and lymphatic vessels in cancer progression Oncogene 31 2012 4499 4508
20. J.B. Dixon Mechanisms of chylomicron uptake into lacteals Ann. N. Y. Acad. Sci. 1207 Suppl. 1 2010 E52 E57
21. H.Y. Lim, C.H. Thiam, K.P. Yeo, R. Bisoendial, C.S. Hii, and K.C. McGrath et al. Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL Cell Metab. 17 2013 671 684
22. C. Martel, W. Li, B. Fulp, A.M. Platt, E.L. Gautier, and M. Westerterp et al. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice J. Clin. Invest. 123 2013 1571 1579
23. H. Wiig, A. Schroder, W. Neuhofer, J. Jantsch, C. Kopp, and T.V. Karlsen et al. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure J. Clin. Invest. 123 2013 2803 2815
24. A. Pfenniger, J.P. Derouette, V. Verma, X. Lin, B. Foglia, and W. Coombs et al. Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells Arterioscler. Thromb. Vasc. Biol. 30 2010 827 834
25. T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes J. Biol. Chem. 273 1998 12725 12731 (Pubitemid 28246824)
26. B.N. Giepmans, and W.H. Moolenaar The gap junction protein connexin 43 interacts with the second PDZ domain of the zona occludens-1 protein Curr. Biol. 8 1998 931 934 (Pubitemid 28371760)
27. S.L. Fowler, M. Akins, H. Zhou, D. Figeys, and S.A. Bennett The liver connexin 32 interactome is a novel plasma membrane-mitochondrial signaling nexus J. Proteome Res. 12 2013 2597 2610
28. C.C. Compton, and E. Raviola Structure of the sinus-lining cells in the popliteal lymph node of the rabbit Anat. Rec. 212 1985 408 423 (Pubitemid 16237520)
29. N.G. McHale, and M.K. Meharg Co-ordination of pumping in isolated bovine lymphatic vessels J. Physiol. 450 1992 503 512
30. T. Krenacs, and M. Rosendaal Immunohistological detection of gap junctions in human lymphoid tissue: connexin 43 in follicular dendritic and lymphoendothelial cells J. Histochem. Cytochem. 43 1995 1125 1137
31. J.N. Benoit, D.C. Zawieja, A.H. Goodman, and H.J. Granger Characterization of intact mesenteric lymphatic pump and its responsiveness to acute edemagenic stress Am. J. Physiol. 257 1989 H2059 H2069
32. D.C. Zawieja, K.L. Davis, R. Schuster, W.M. Hinds, and H.J. Granger Distribution, propagation, and coordination of contractile activity in lymphatics Am. J. Physiol. 264 1993 H1283 H1291
33. N. Wick, P. Saharinen, J. Saharinen, E. Gurnhofer, C.W. Steiner, and I. Raab et al. Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro Physiol. Genomics 28 2007 179 192 (Pubitemid 46702006)
34. J.W. Shin, R. Huggenberger, and M. Detmar Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis Blood 112 2008 2318 2326
35. K.A. Kleopa, J.L. Orthmann, A. Enriquez, D.L. Paul, and S.S. Scherer Unique distributions of the gap junction proteins connexin 29, connexin 32, and connexin 47 in oligodendrocytes Glia 47 2004 346 357 (Pubitemid 39295418)
36. B. Odermatt, K. Wellershaus, A. Wallraff, G. Seifert, J. Degen, and C. Euwens et al. Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS J. Neurosci. 23 2003 4549 4559 (Pubitemid 36706185)
37. E. Bazigou, S. Xie, C. Chen, A. Weston, N. Miura, and L. Sorokin et al. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis Dev. Cell 17 2009 175 186
38. C. Norrmen, K.I. Ivanov, J. Cheng, N. Zangger, M. Delorenzi, and M. Jaquet et al. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1 J. Cell Biol. 185 2009 439 457
39. A. Pfenniger, C. Wong, E. Sutter, S. Cuhlmann, S. Dunoyer-Geindre, and F. Mach et al. Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells J. Mol. Cell. Cardiol. 53 2012 299 309
40. M. Kumai, K. Nishii, K. Nakamura, N. Takeda, M. Suzuki, and Y. Shibata Loss of connexin 45 causes a cushion defect in early cardiogenesis Development 127 2000 3501 3512
41. F. Tatin, A. Taddei, A. Weston, E. Fuchs, D. Devenport, and F. Tissir et al. Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis Dev. Cell 26 2013 31 44
42. C. Niehrs The complex world of WNT receptor signalling Nat. Rev. Mol. Cell Biol. 13 2012 767 779
43. J.D. Kanady, and A.M. Simon Lymphatic communication: connexin junction, what's your function? Lymphology 44 2011 95 102
44. H.M. Heller, and M.N. Swartz Nodular lymphangitis: clinical features, differential diagnosis and management Curr. Clin. Top. Infect. Dis. 14 1994 142 158
45. T.B. Nutman Insights into the pathogenesis of disease in human lymphatic filariasis Lymphat. Res. Biol. 11 2013 144 148
46. R.E. Ferrell, C.J. Baty, M.A. Kimak, J.M. Karlsson, E.C. Lawrence, and M. Franke-Snyder et al. GJC2 missense mutations cause human lymphedema Am. J. Hum. Genet. 86 2010 943 948
47. M. Henneke, P. Combes, S. Diekmann, E. Bertini, K. Brockmann, and A.P. Burlina et al. GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease Neurology 70 2008 748 754
48. S. Diekmann, M. Henneke, B.C. Burckhardt, and J. Gartner Pelizaeus-Merzbacher-like disease is caused not only by a loss of connexin 47 function but also by a hemichannel dysfunction Eur. J. Hum. Genet. 18 2010 985 992
49. P. Ostergaard, M.A. Simpson, G. Brice, S. Mansour, F.C. Connell, and A. Onoufriadis et al. Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype J. Med. Genet. 48 2011 251 255
50. D.N. Finegold, V. Schacht, M.A. Kimak, E.C. Lawrence, E. Foeldi, and J.M. Karlsson et al. HGF and MET mutations in primary and secondary lymphedema Lymphat. Res. Biol. 6 2008 65 68 (Pubitemid 351873446)
51. D.N. Finegold, C.J. Baty, K.Z. Knickelbein, S. Perschke, S.E. Noon, and D. Campbell et al. Connexin 47 mutations increase risk for secondary lymphedema following breast cancer treatment Clin. Cancer Res. 18 2012 2382 2390
52. H.V. Van Rijen, R. Wilders, A.C. Van Ginneken, and H.J. Jongsma Quantitative analysis of dual whole-cell voltage-clamp determination of gap junctional conductance Pflugers Arch. 436 1998 141 151 (Pubitemid 28206327)
53. G. Brice, P. Ostergaard, S. Jeffery, K. Gordon, P. Mortimer, and S. Mansour A novel mutation in GJA1 causing oculodentodigital syndrome and primary lymphoedema in a three generation family Clin. Genet. 84 2013 378 381
54. W.A. Paznekas, B. Karczeski, S. Vermeer, R.B. Lowry, M. Delatycki, and F. Laurence et al. GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype Hum. Mutat. 30 2009 724 733
55. M.S. Kim, G.B. Gloor, and D. Bai The distribution and functional properties of Pelizaeus-Merzbacher-like disease-linked Cx47 mutations on Cx47/Cx47 homotypic and Cx47/Cx43 heterotypic gap junctions Biochem. J. 452 2013 249 258
56. D. May, O. Tress, G. Seifert, and K. Willecke Connexin 47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin 43 protein in astrocytes J. Neurosci. 33 2013 7985 7996
57. A. Rodriguez-Sinovas, J.A. Sanchez, C. Fernandez-Sanz, M. Ruiz-Meana, and D. Garcia-Dorado Connexin and pannexin as modulators of myocardial injury Biochim. Biophys. Acta 1818 2012 1962 1970
58. J.A. Palatinus, J.M. Rhett, and R.G. Gourdie The connexin 43 carboxyl terminus and cardiac gap junction organization Biochim. Biophys. Acta 1818 2012 1831 1843
59. M.J. Meens, A. Pfenniger, B.R. Kwak, and M. Delmar Regulation of cardiovascular connexins by mechanical forces and junctions Cardiovasc. Res. 99 2013 304 314
60. M. Delmar, and N. Makita Cardiac connexins, mutations and arrhythmias Curr. Opin. Cardiol. 27 2012 236 241