Renal connexins and blood pressure

Biochimica et Biophysica Acta - Biomembranes

Volumn 1818, Issue 8, 2012, Pages 1903-1908

  Kurtz, Armin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Cx30; Cx40; Cx40A96S mutation; Hypertension; Renin angiotensin system; Sodium resorption

Indexed keywords

CONNEXIN 37; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; GAP JUNCTION PROTEIN;

BLOOD PRESSURE REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; HENLE LOOP; HUMAN; HYPERRENINEMIA; HYPERTENSION; KIDNEY; KIDNEY PROXIMAL TUBULE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; VASCULARIZATION;

ANIMALS; BLOOD PRESSURE; CONNEXIN 43; CONNEXINS; HOMEOSTASIS; HUMANS; KIDNEY; KIDNEY TUBULES; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; NEPHRONS; RENAL ARTERY; RENIN;

EID: 84861642108     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2011.05.023     Document Type: Review

References (63)

1. C. Biava, and M. West Fine structure of normal human juxtaglomerular cells. I. General structure and intercellular relationships Am. J. Pathol. 49 1966 679 721
2. R. Taugner, A. Schiller, B. Kaissling, and W. Kriz Gap junctional coupling between the JGA and the glomerular tuft Cell Tissue Res. 186 1978 279 285
3. D. Mink, A. Schiller, W. Kriz, and R. Taugner Interendothelial junctions in kidney vessels Cell Tissue Res. 236 1984 567 576
4. F.J. Silverblatt, and R.E. Bulger Gap junctions occur in vertebrate renal proximal tubule cells J. Cell Biol. 47 1970 513 515
5. K. Kuhn, and E. Reale Junctional complexes of the tubular cells in the human kidney as revealed with freeze-fracture Cell Tissue Res. 160 1975 193 205
6. C. Pricam, F. Humbert, A. Perrelet, and L. Orci Gap junctions in mesangial and lacis cells J. Cell Biol. 63 1974 349 354
7. C. Pricam, F. Humbert, A. Perrelet, and L. Orci A freeze-etch study of the tight junctions of the rat kidney tubules Lab. Invest. 30 1974 286 291
8. L. Barajas, L. Liu, and M. Tucker Localization of connexin43 in rat kidney Kidney Int. 46 1994 621 626
9. R. Guo, L. Liu, and L. Barajas RT-PCR study of the distribution of connexin 43 mRNA in the glomerulus and renal tubular segments Am. J. Physiol. 275 1998 R439 R447
10. J.A. Haefliger, R. Bruzzone, N.A. Jenkins, D.J. Gilbert, N.G. Copeland, and D.L. Paul Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping J. Biol. Chem. 267 1992 2057 2064
11. H. Hennemann, H.J. Schwarz, and K. Willecke Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and - 45 cDNAs Eur. J. Cell Biol. 57 1992 51 58
12. K. Hwan Seul, and E.C. Beyer Heterogeneous localization of connexin40 in the renal vasculature Microvasc. Res. 59 2000 140 148
13. D.L. Paul Molecular cloning of cDNA for rat liver gap junction protein J. Cell Biol. 103 1986 123 134
14. D.L. Paul, L. Ebihara, L.J. Takemoto, K.I. Swenson, and D.A. Goodenough Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes J. Cell Biol. 115 1991 1077 1089
15. M.A. Tucker, and L. Barajas Rat connexins 30.3 and 31 are expressed in the kidney Exp. Cell Res. 213 1994 224 230
16. J.T. Zhang, and B.J. Nicholson Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA J. Cell Biol. 109 1989 3391 3401
17. F. Hanner, C.M. Sorensen, N.H. Holstein-Rathlou, and J. Peti-Peterdi Connexins and the kidney Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 2010 R1143 R1155
18. C. Wagner Function of connexins in the renal circulation Kidney Int. 73 2008 547 555
19. J. Yao, T. Oite, and M. Kitamura Gap junctional intercellular communication in the juxtaglomerular apparatus Am. J. Physiol. Renal Physiol. 296 2009 F939 F946
20. K. Sainio, S.F. Gilbert, E. Lehtonen, M. Nishi, N.M. Kumar, N.B. Gilula, and L. Saxen Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes Development 115 1992 827 837
21. A. Butterweck, U. Gergs, C. Elfgang, K. Willecke, and O. Traub Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells J. Membr. Biol. 141 1994 247 256
22. J.A. Haefliger, N. Krattinger, D. Martin, T. Pedrazzini, A. Capponi, B. Doring, A. Plum, A. Charollais, K. Willecke, and P. Meda Connexin43-dependent mechanism modulates renin secretion and hypertension J. Clin. Invest. 116 2006 405 413
23. B. Nicholson, R. Dermietzel, D. Teplow, O. Traub, K. Willecke, and J.P. Revel Two homologous protein components of hepatic gap junctions Nature 329 1987 732 734
24. F. Hanner, M. Schnichels, Q. Zheng-Fischhofer, L.E. Yang, I. Toma, K. Willecke, A.A. McDonough, and J. Peti-Peterdi Connexin 30.3 is expressed in the kidney but not regulated by dietary salt or high blood pressure Cell Commun. Adhes. 15 2008 219 230
25. Q. Zheng-Fischhofer, M. Schnichels, E. Dere, J. Strotmann, N. Loscher, F. McCulloch, M. Kretz, J. Degen, H. Reucher, J.I. Nagy, J. Peti-Peterdi, J.P. Huston, H. Breer, and K. Willecke Characterization of connexin30.3-deficient mice suggests a possible role of connexin30.3 in olfaction Eur. J. Cell Biol. 86 2007 683 700
26. A. Stoessel, N. Himmerkus, M. Bleich, S. Bachmann, and F. Theilig Connexin 37 is localized in renal epithelia and responds to changes in dietary salt intake Am. J. Physiol. Renal Physiol. 298 2010 F216 F223
27. X.F. Figueroa, and B.R. Duling Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction Am. J. Physiol. Heart Circ. Physiol. 295 2008 H2001 H2007
28. M. Boerma, L. Forsberg, L. Van Zeijl, R. Morgenstern, U. De Faire, C. Lemne, D. Erlinge, T. Thulin, Y. Hong, and I.A. Cotgreave A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development J. Intern. Med. 246 1999 211 218
29. F. McCulloch, R. Chambrey, D. Eladari, and J. Peti-Peterdi Localization of connexin 30 in the luminal membrane of cells in the distal nephron Am. J. Physiol. Renal Physiol. 289 2005 F1304 F1312
30. A. Sipos, S.L. Vargas, I. Toma, F. Hanner, K. Willecke, and J. Peti-Peterdi Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis J. Am. Soc. Nephrol. 20 2009 1724 1732
31. E. Mironova, J. Peti-Peterdi, V. Bugaj, and J.D. Stockand Diminished paracrine regulation of the epithelial Na+ channel by purinergic signaling in mice lacking connexin 30 J. Biol. Chem. 286 2011 1054 1060
32. R. Dobrowolski, and K. Willecke Connexin-caused genetic diseases and corresponding mouse models Antioxid. Redox Signal. 11 2009 283 295
33. L. Kurtz, U. Janssen-Bienhold, A. Kurtz, and C. Wagner Connexin expression in renin-producing cells J. Am. Soc. Nephrol. 20 2009 506 512
34. J. Zhang, and C.E. Hill Differential connexin expression in preglomerular and postglomerular vasculature: accentuation during diabetes Kidney Int. 68 2005 1171 1185
35. F. Hanner, J. von Maltzahn, S. Maxeiner, I. Toma, A. Sipos, O. Kruger, K. Willecke, and J. Peti-Peterdi Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 2008 R371 R380
36. O. Kruger, A. Plum, J.S. Kim, E. Winterhager, S. Maxeiner, G. Hallas, S. Kirchhoff, O. Traub, W.H. Lamers, and K. Willecke Defective vascular development in connexin 45-deficient mice Development 127 2000 4179 4193
37. B. Kurt, L. Kurtz, M.L. Sequeira-Lopez, R.A. Gomez, K. Willecke, C. Wagner, and A. Kurtz Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells Am. J. Physiol. Renal Physiol. 300 2011 F743 F748
38. T. Takenaka, T. Inoue, Y. Kanno, H. Okada, K.R. Meaney, C.E. Hill, and H. Suzuki Expression and role of connexins in the rat renal vasculature Kidney Int. 73 2008 415 422
39. L. Kurtz, K. Madsen, B. Kurt, B.L. Jensen, S. Walter, B. Banas, C. Wagner, and A. Kurtz High-level connexin expression in the human juxtaglomerular apparatus Nephron Physiol. 116 2010 1 8
40. H. Castrop, K. Hocherl, A. Kurtz, F. Schweda, V. Todorov, and C. Wagner Physiology of kidney renin Physiol. Rev. 90 2010 607 673
41. M. Theis, C. de Wit, T.M. Schlaeger, D. Eckardt, O. Kruger, B. Doring, W. Risau, U. Deutsch, U. Pohl, and K. Willecke Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene Genesis 29 2001 1 13
42. Y. Liao, K.H. Day, D.N. Damon, and B.R. Duling Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice Proc. Natl. Acad. Sci. U. S. A. 98 2001 9989 9994
43. A.G. Reaume, P.A. de Sousa, S. Kulkarni, B.L. Langille, D. Zhu, T.C. Davies, S.C. Juneja, G.M. Kidder, and J. Rossant Cardiac malformation in neonatal mice lacking connexin43 Science 267 1995 1831 1834
44. B. Arensbak, H.B. Mikkelsen, F. Gustafsson, T. Christensen, and N.H. Holstein-Rathlou Expression of connexin 37, 40, and 43 mRNA and protein in renal preglomerular arterioles Histochem. Cell Biol. 115 2001 479 487
45. C. Wagner, L. Kurtz, F. Schweda, A.M. Simon, and A. Kurtz Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney Pflugers Arch. 459 2009 151 158
46. A.S. De Vriese, J. Van de Voorde, and N.H. Lameire Effects of connexin-mimetic peptides on nitric oxide synthase- and cyclooxygenase- independent renal vasodilation Kidney Int. 61 2002 177 185
47. C. Wagner, C. de Wit, L. Kurtz, C. Grunberger, A. Kurtz, and F. Schweda Connexin40 is essential for the pressure control of renin synthesis and secretion Circ. Res. 100 2007 556 563
48. N. Krattinger, A. Capponi, L. Mazzolai, J.F. Aubert, D. Caille, P. Nicod, G. Waeber, P. Meda, and J.A. Haefliger Connexin40 regulates renin production and blood pressure Kidney Int. 72 2007 814 822
49. A. Just, L. Kurtz, C. de Wit, C. Wagner, A. Kurtz, and W.J. Arendshorst Connexin 40 mediates the tubuloglomerular feedback contribution to renal blood flow autoregulation J. Am. Soc. Nephrol. 20 2009 1577 1585
50. F. Alonso, F.X. Boittin, J.L. Beny, and J.A. Haefliger Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta Am. J. Physiol. Heart Circ. Physiol. 299 2010 H1365 H1373
51. C. de Wit, F. Roos, S.S. Bolz, and U. Pohl Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion Physiol. Genomics 13 2003 169 177
52. C. Wagner, A. Jobs, F. Schweda, L. Kurtz, B. Kurt, M.L. Lopez, R.A. Gomez, T.A. van Veen, C. de Wit, and A. Kurtz Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension Kidney Int. 78 2010 762 768
53. M.H. Gollob, D.L. Jones, A.D. Krahn, L. Danis, X.Q. Gong, Q. Shao, X. Liu, J.P. Veinot, A.S. Tang, A.F. Stewart, F. Tesson, G.J. Klein, R. Yee, A.C. Skanes, G.M. Guiraudon, L. Ebihara, and D. Bai Somatic mutations in the connexin 40 gene (GJA5) in atrial fibrillation N. Engl. J. Med. 354 2006 2677 2688
54. I. Lubkemeier, K. Machura, L. Kurtz, B. Neubauer, R. Dobrowolski, F. Schweda, C. Wagner, K. Willecke, and A. Kurtz The connexin 40 A96S mutation causes renin-dependent hypertension J. Am. Soc. Nephrol. 22 2011 1031 1040
55. J. Peti-Peterdi Calcium wave of tubuloglomerular feedback Am. J. Physiol. Renal Physiol. 291 2006 F473 F480
56. I. Toma, E. Bansal, E.J. Meer, J.J. Kang, S.L. Vargas, and J. Peti-Peterdi Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 2008 R1769 R1776
57. M.J. Ryan, B. Liu, M.T. Herbowy, K.W. Gross, and G. Hajduczok Intercellular communication between renin expressing As4.1 cells, endothelial cells and smooth muscle cells Life Sci. 72 2003 1289 1301
58. L. Kurtz, F. Schweda, C. de Wit, W. Kriz, R. Witzgall, R. Warth, A. Sauter, A. Kurtz, and C. Wagner Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium J. Am. Soc. Nephrol. 18 2007 1103 1111
59. H. Scholz, M. Hamann, K.H. Gotz, and A. Kurtz Role of calcium ions in the pressure control of renin secretion from the kidneys Pflugers Arch. 428 1994 173 178
60. F. Schweda, and A. Kurtz Cellular mechanism of renin release Acta Physiol. Scand. 181 2004 383 390
61. M. Firouzi, B. Kok, W. Spiering, A. Busjahn, C.R. Bezzina, J.M. Ruijter, B.P. Koeleman, M. Schipper, W.A. Groenewegen, H.J. Jongsma, and P.W. de Leeuw Polymorphisms in human connexin 40 gene promoter are associated with increased risk of hypertension in men J. Hypertens. 24 2006 325 330
62. T.H. Braunstein, C.M. Sorensen, and N.H. Holstein-Rathlou Connexin abundance in resistance vessels from the renal microcirculation in normo- and hypertensive rats APMIS 117 2009 268 276
63. C. Wiese, A. Rolletschek, G. Kania, P. Blyszczuk, K.V. Tarasov, Y. Tarasova, R.P. Wersto, K.R. Boheler, and A.M. Wobus Nestin expression - a property of multi-lineage progenitor cells? Cell. Mol. Life Sci. 61 2004 2510 2522