Gastroduodenal mechanisms underlying functional gastric disorders

Digestive Diseases

Volumn 32, Issue 3, 2014, Pages 222-229

  Carbone, F ^a   Tack, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Functional dyspepsia; Gastric accommodation; Gastric emptying; Gastric mechanosensitivity; Helicobacter pylori

Indexed keywords

ACCOMMODATION; ARTICLE; DYSPEPSIA; GASTRODUODENAL MECHANISM; HELICOBACTER PYLORI; HUMAN; HYPERSENSITIVITY; IMPAIRED GASTRIC ACCOMMODATION; MEMBRANE PERMEABILITY; MUCOSA INFLAMMATION; PRIORITY JOURNAL; STOMACH DISEASE; STOMACH EMPTYING; VISCERAL HYPERSENSITIVITY; DIGESTIVE SYSTEM FUNCTION DISORDER; DISEASE SEVERITY; DUODENUM DISEASE; GASTRIC ACCOMMODATION; INFLAMMATION; INTESTINE MUCOSA PERMEABILITY; MENTAL STRESS; PATHOPHYSIOLOGY; STOMACH DISTENSION; STOMACH FUNCTION; ANIMAL; DUODENUM; GASTROINTESTINAL DISEASE; PATHOLOGY; STOMACH; STOMACH MUCOSA;

ANIMALS; DUODENUM; GASTRIC EMPTYING; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; HUMANS; INFLAMMATION; STOMACH;

EID: 84898836345     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000357854     Document Type: Article

References (83)

1. Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al: Functional gastroduodenal disorders. Gastroenterology 2006; 130: 1466-1479.
2. Tack J, Talley NJ: Functional dyspepsia-symptoms, definitions and validity of the Rome III criteria. Nat Rev Gastroenterol Hepatol 2013; 10: 134-141.
3. Ford AC, Forman D, Bailey AG, Axon AT, Moayyedi P: Effect of dyspepsia on survival: A longitudinal 10-year follow-up study. Am J Gastroenterol 2012; 107: 912-921.
4. El-Serag HB, Talley NJ: Health-related quality of life in functional dyspepsia. Aliment Pharmacol Ther 2003; 18: 387-393.
5. Moayyedi P, Mason J: Clinical and economic consequences of dyspepsia in the community. Gut 2002; 50(suppl 4):iv10-iv12.
6. Tack J, Talley NJ: Functional dyspepsia-symptoms, definitions and validity of the Rome III criteria. Nat Rev Gastroenterol Hepatol 2013; 10: 134-141.
7. Talley NJ: Review article: Functional dyspepsia-should treatment be targeted on disturbed physiology Aliment Pharmacol Ther 1995; 9: 107-115.
8. Vanheel H, Farré R: Changes in gastrointestinal tract function and structure in functional dyspepsia. Nat Rev Gastroenterol Hepatol 2013; 10: 142-149.
9. Van Oudenhove L, Aziz Q: The role of psychosocial factors and psychiatric disorders in functional dyspepsia. Nat Rev Gastroenterol Hepatol 2013; 10: 158-167.
10. Kindt S, Tack J: Impaired gastric accommodation and its role in dyspepsia. Gut 2006; 55: 1685-1691.
11. Janssen P, Vanden Berghe P, Verschueren S, Lehmann A, Depoortere I, Tack J: Review article: The role of gastric motility in the control of food intake. Aliment Pharmacol Ther 2011; 33: 880-894.
12. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J: Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998; 115: 1346-1352.
13. Piessevaux H, Tack J, Wilmer A, Coulie B, Geubel A, Janssens J: Perception of changes in wall tension of the proximal stomach in humans. Gut 2001; 49: 203-208.
14. Paintal AS: A study of gastric stretch receptors; their role in the peripheral mechanism of satiation of hunger and thirst. J Physiol 1954; 126: 255-270.
15. Salet GA, Samsom M, Roelofs JM, van Berge Henegouwen GP, Smout AJ, Akkermans LM: Responses to gastric distension in functional dyspepsia. Gut 1998; 42: 823-829.
16. Tack J, Demedts I, Meulemans A, Schuurkes J, Janssens J: Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans. Gut 2002; 51: 219-224.
17. Tonini M, De Giorgio R, De Ponti F, Sternini C, Spelta V, Dionigi P, et al: Role of nitric oxide-and vasoactive intestinal polypeptidecontaining neurones in human gastric fundus strip relaxations. Br J Pharmacol 2000; 129: 12-20.
18. Takahashi T, Owyang C: Vagal control of nitric oxide and vasoactive intestinal polypeptide release in the regulation of gastric relaxation in rat. J Physiol 1995; 484: 481-492.
19. Grover M, Camilleri M: Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases. J Gastroenterol 2013; 48: 177-181.
20. Gershon MD, Tack J: The serotonin signaling system: From basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132: 397-414.
21. Geeraerts B, Van Oudenhove L, Boesmans W, Vos R, Vanden Berghe P, Tack J: Influence of acute tryptophan depletion on gastric sensorimotor function in humans. Am J Physiol Gastrointest Liver Physiol 2011; 300:G228-G235.
22. Tack J, Broekaert D, Coulie B, Fischler B, Janssens J: Influence of the selective serotonin re-uptake inhibitor, paroxetine, on gastric sensorimotor function in humans. Aliment Pharmacol Ther 2003; 17: 603-608.
23. Tack J, Broeckaert D, Coulie B, Janssens J: The influence of cisapride on gastric tone and the perception of gastric distension. Aliment Pharmacol Ther 1998; 12: 761-766.
24. Tack J, Janssen P, Bisschops R, Vos R, Phillips T, Tougas G: Influence of tegaserod on proximal gastric tone and on the perception of gastric distention in functional dyspepsia. Neurogastroenterol Motil 2011; 23:e32-e39.
25. Tack J, Vos R, Janssens J, Salter J, Jauffret S, Vandeplassche G: Influence of tegaserod on proximal gastric tone and on the perception of gastric distension. Aliment Pharmacol Ther 2003; 18: 1031-1037.
26. Van Oudenhove L, Kindt S, Vos R, Coulie B, Tack J: Influence of buspirone on gastric sensorimotor function in man. Aliment Pharmacol Ther 2008; 28: 1326-1333.
27. Tack J, Janssen P, Masaoka T, Farre R, Van Oudenhove L: Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. Clin Gastroenterol Hepatol 2012; 10: 1239-1245.
28. Ameloot K, Janssen P, Scarpellini E, Vos R, Boesmans W, Depoortere I, et al: Endocannabinoid control of gastric sensorimotor function in man. Aliment Pharmacol Ther 2010; 31: 1123-1131.
29. Janssen P, Pottel H, Vos R, Tack J: Endogenously released opioids mediate meal-induced gastric relaxation via peripheral muopioid receptors. Aliment Pharmacol Ther 2011; 33: 607-614.
30. Carrasco M, Azpiroz F, Malagelada JR: Modulation of gastric accommodation by duodenal nutrients. World J Gastroenterol 2005; 11: 4848-4851.
31. Troncon LE, Bennett RJ, Ahluwalia NK, Thompson DG: Abnormal intragastric distribution of food during gastric emptying in functional dyspepsia patients. Gut 1994; 35: 327-332.
32. Caldarella MP, Azpiroz F, Malagelada JR: Antro-fundic dysfunctions in functional dyspepsia. Gastroenterology 2003; 124: 1220-1229.
33. Farré R, Tack J: Food and symptom generation in functional gastrointestinal disorders: Physiological aspects. Am J Gastroenterol 2013; 108: 698-706.
34. Bouras EP, Vazquez Roque MI, Aranda-Michel J: Gastroparesis: From concepts to management. Nutr Clin Pract 2013; 28: 437-447.
35. Parkman HP, Camilleri M, Farrugia G, Mc-Callum RW, Bharucha AE, Mayer EA, et al: Gastroparesis and functional dyspepsia: Excerpts from the AGA/ANMS meeting. Neurogastroenterol Motil 2010; 22: 113-133.
36. Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L: Clinical guideline: Management of gastroparesis. Am J Gastroenterol 2013; 108: 18-37; quiz 38.
37. Masaoka T, Tack J: Gastroparesis: Current concepts and management. Gut Liver 2009; 3: 166-173.
38. Krishnan B, Babu S, Walker J, Walker AB, Pappachan JM: Gastrointestinal complications of diabetes mellitus. World J Diabetes 2013; 4: 51-63.
39. Choung RS, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ: Risk of gastroparesis in subjects with type 1 and 2 diabetes in the general population. Am J Gastroenterol 2012; 107: 82-88.
40. Hasler WL: Gastroparesis: Pathogenesis, diagnosis and management. Nat Rev Gastroenterol Hepatol 2011; 8: 438-453.
41. Lacy BE: Functional dyspepsia and gastroparesis: One disease or two Am J Gastroenterol 2012; 107: 1615-1620.
42. Janssen P, van Oudenhove L, Bisschops R, Tack J: Idiopathic gastroparesis or functional dyspepsia with delayed gastric emptying: where is the difference Gastroenterology 2011; 140: 2145-2146; author reply 2146-2148.
43. Sarnelli G, Caenepeel P, Geypens B, Janssens J, Tack J: Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003; 98: 783-788.
44. Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, Marengo M, Corinaldesi R: Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996; 110: 1036-1042.
45. Talley NJ, Locke GR 3rd, Lahr BD, Zinsmeister AR, Tougas G, Ligozio G, Rojavin MA, Tack J: Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut 2006; 55: 933-939.
46. Karamanolis G, Caenepeel P, Arts J, Tack J: Determinants of symptom pattern in idiopathic severely delayed gastric emptying: Gastric emptying rate or proximal stomach dysfunction Gut 2007; 56: 29-36.
47. Janssen P, Harris MS, Jones M, Masaoka T, Farre R, Tornblom H, et al: The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis. Am J Gastroenterol 2013; 108: 1382-1391.
48. Camilleri M, Coulie B, Tack JF: Visceral hypersensitivity: Facts, speculations, and challenges. Gut 2001; 48: 125-131.
49. Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada JR: Gastric tone determines the sensitivity of the stomach to distention. Gastroenterology 1995; 108: 330-336.
50. Tack J, Caenepeel P, Corsetti M, Janssens J: Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention. Gastroenterology 2004; 127: 1058-1066.
51. Mertz H, Fullerton S, Naliboff B, Mayer EA: Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998; 42: 814-822.
52. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J: Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 2001; 121: 526-535.
53. Bisschops R, Karamanolis G, Arts J, Caenepeel P, Verbeke K, Janssens J, Tack J: Relationship between symptoms and ingestion of a meal in functional dyspepsia. Gut 2008; 57: 1495-1503.
54. Lee KJ, Vos R, Janssens J, Tack J: Influence of duodenal acidification on the sensorimotor function of the proximal stomach in humans. Am J Physiol Gastrointest Liver Physiol 2004; 286:G278-G284.
55. Lee KJ, Demarchi B, Demedts I, Sifrim D, Raeymaekers P, Tack J: A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea. Am J Gastroenterol 2004; 99: 1765-1773.
56. Farré R, Vanheel H, Vanuytsel T, Masaoka T, Tornblom H, Simren M, et al: In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity. Gastroenterology 2013; 145: 566-573.
57. Hammer J, Fuhrer M, Pipal L, Matiasek J: Hypersensitivity for capsaicin in patients with functional dyspepsia. Neurogastroenterol Motil 2008; 20: 125-133.
58. Holzer P: Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 1991; 43: 143-201.
59. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D: The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-824.
60. Anand P, Aziz Q, Willert R, van Oudenhove L: Peripheral and central mechanisms of visceral sensitization in man. Neurogastroenterol Motil 2007; 19(suppl 1):29-46.
61. Fuhrer M, Vogelsang H, Hammer J: A placebo-controlled trial of an oral capsaicin load in patients with functional dyspepsia. Neurogastroenterol Motil 2011; 23: 918-e397.
62. Oshima T, Okugawa T, Tomita T, Sakurai J, Toyoshima F, Watari J, et al: Generation of dyspeptic symptoms by direct acid and water infusion into the stomachs of functional dyspepsia patients and healthy subjects. Aliment Pharmacol Ther 2012; 35: 175-182.
63. Schwartz MP, Samsom M, Smout AJ: Chemospecific alterations in duodenal perception and motor response in functional dyspepsia. Am J Gastroenterol 2001; 96: 2596-2602.
64. Samsom M, Verhagen MA, vanBerge Henegouwen GP, Smout AJ: Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients. Gastroenterology 1999; 116: 515-520.
65. di Stefano M, Vos R, Vanuytsel T, Janssens J, Tack J: Prolonged duodenal acid perfusion and dyspeptic symptom occurrence in healthy volunteers. Neurogastroenterol Motil 2009; 21: 712-e40.
66. Turner JR: Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009; 9: 799-809.
67. Ohman L, Simren M: Pathogenesis of IBS: Role of inflammation, immunity and neuroimmune interactions. Nat Rev Gastroenterol Hepatol 2010; 7: 163-173.
68. Salim SY, Soderholm JD: Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm Bowel Dis 2011; 17: 362-381.
69. Suzuki H, Moayyedi P: Helicobacter pylori infection in functional dyspepsia. Nat Rev Gastroenterol Hepatol 2013; 10: 168-174.
70. Tucci A, Corinaldesi R, Stanghellini V, Tosetti C, Di Febo G, Paparo GF, et al: Helicobacter pylori infection and gastric function in patients with chronic idiopathic dyspepsia. Gastroenterology 1992; 103: 768-774.
71. Mearin F, de Ribot X, Balboa A, Salas A, Varas MJ, Cucala M, et al: Does Helicobacter pylori infection increase gastric sensitivity in functional dyspepsia Gut 1995; 37: 47-51.
72. Sarnelli G, Cuomo R, Janssens J, Tack J: Symptom patterns and pathophysiological mechanisms in dyspeptic patients with and without Helicobacter pylori . Dig Dis Sci 2003; 48: 2229-2236.
73. Wu J, Xu S, Zhu Y: Helicobacter pylori CagA: A critical destroyer of the gastric epithelial barrier. Dig Dis Sci 2013; 58: 1830-1837.
74. Fiorentino M, Ding H, Blanchard TG, Czinn SJ, Sztein MB, Fasano A: Helicobacter pylori-induced disruption of monolayer permeability and proinflammatory cytokine secretion in polarized human gastric epithelial cells. Infect Immun 2013; 81: 876-883.
75. Dizdar V, Gilja OH, Hausken T: Increased visceral sensitivity in Giardia-induced postinfectious irritable bowel syndrome and functional dyspepsia. Effect of the 5HT3-antagonist ondansetron. Neurogastroenterol Motil 2007; 19: 977-982.
76. Mearin F, Perez-Oliveras M, Perello A, Vinyet J, Ibanez A, Coderch J, et al: Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: One-year follow-up cohort study. Gastroenterology 2005; 129: 98-104.
77. Tack J, Demedts I, Dehondt G, Caenepeel P, Fischler B, Zandecki M, et al: Clinical and pathophysiological characteristics of acuteonset functional dyspepsia. Gastroenterology 2002; 122: 1738-1747.
78. Kindt S, Tertychnyy A, de Hertogh G, Geboes K, Tack J: Intestinal immune activation in presumed post-infectious functional dyspepsia. Neurogastroenterol Motil 2009; 21: 832-e56.
79. Talley NJ, Walker MM, Aro P, Ronkainen J, Storskrubb T, Hindley LA, et al: Non-ulcer dyspepsia and duodenal eosinophilia: An adult endoscopic population-based case-control study. Clin Gastroenterol Hepatol 2007; 5: 1175-1183.
80. Walker MM, Talley NJ, Prabhakar M, Pennaneac'h CJ, Aro P, Ronkainen J, et al: Duodenal mastocytosis, eosinophilia and intraepithelial lymphocytosis as possible disease markers in the irritable bowel syndrome and functional dyspepsia. Aliment Pharmacol Ther 2009; 29: 765-773.
81. Li X, Chen H, Lu H, Li W, Chen X, Peng Y, et al: The study on the role of inflammatory cells and mediators in post-infectious functional dyspepsia. Scand J Gastroenterol 2010; 45: 573-581.
82. Vanheel H, Vicario M, Vanuytsel T, Van Oudenhove L, Martinez C, Keita AV, et al: Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut 2013, Epub ahead of print.
83. Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, et al: Psychological stress and corticotropinreleasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 2013, Epub ahead of print.