Influence of acute tryptophan depletion on gastric sensorimotor function in humans

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 300, Issue 2, 2011, Pages

  Geeraerts, Brecht ^a   Van Oudenhove, Lukas ^a   Boesmans, Werend ^a   Vos, Rita ^a   Vanden Berghe, Pieter ^a   Tack, Jan ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Satiety drinking test; Serotonin

Indexed keywords

SEROTONIN; TRYPTOPHAN;

ACUTE TRYPTOPHAN DEPLETION; ADULT; AMINO ACID BLOOD LEVEL; ANXIETY; ARTICLE; BAROSTAT; CELL COUNT; CONTROLLED STUDY; DEPLETION; DRINKING; DUODENUM BIOPSY; DUODENUM MUCOSA; ENTEROCHROMAFFIN CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTRIC SENSITIVITY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NAUSEA; NORMAL HUMAN; NUTRITIONAL TOLERANCE; PHYSICAL SENSITIVITY; POSTPRANDIAL STATE; PRIORITY JOURNAL; SATIETY; SENSORIMOTOR FUNCTION; STATE TRAIT ANXIETY INVENTORY; STOMACH BIOPSY; STOMACH DISTENSION; STOMACH FUNCTION; STOMACH FUNDUS;

ADULT; ANXIETY; COMPLIANCE; DEPRESSION; DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM; DOUBLE-BLIND METHOD; DYSPEPSIA; EATING; FEMALE; GASTRIC MUCOSA; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; HUMANS; INTESTINAL MUCOSA; MALE; SENSATION; SEROTONIN; STOMACH; TIME FACTORS; TRYPTOPHAN;

EID: 79251589909     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00020.2010     Document Type: Article

References (55)

1. Bell CJ, Hood SD, Nutt DJ. Acute tryptophan depletion. Part II: clinical effects and implications. Aust NZ J Psychiatry 3: 565-574, 2005.
2. Bischoff SC, Mailer R, Pabst O, Weier G, Sedlik W, Li Z, Chen JJ, Murphy DL, Gershon MD. Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice. Am J Physiol Gastrointest Liver Physiol 296: G685-G695, 2009.
3. Charney DS. Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry 59, Suppl 14: 11-14, 1998.
4. Cleare AJ, Bond AJ. The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology (Berl) 118: 72-81, 1995.
5. Coates M, Mahoney C, Linden D, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 126: 1657-1664, 2004. (Pubitemid 38736329)
6. Coleman NS, Marciani L, Blackshaw E, Wright J, Parker M, Yano T, Yamazaki S, Chan PQ, Wilde K, Gowland PA, Perkins AC, Spiller RC. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans. Aliment Pharmacol Ther 18: 1039-1048, 2003.
7. Cuomo R, Vandaele P, Coulie B, Peeters T, Depoortere I, Janssens J, Tack J. Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways. Am J Gastroenterol 101: 804-811, 2006.
8. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47: 411-418, 1990.
9. Drossman DA, Corazziari E, Talley NJ, Thompson W, Whitehead WE. Rome II: a multinational consensus document on functional gastrointestinal disorders. Gut 45: 1-81, 1999.
10. Ellenbogen MA, Young SN, Dean P, Palmour RM, Benkelfat C. Mood response to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability. Neuropsychopharmacology 15: 465-474, 1996.
11. Gershon MD. Review article: serotonin receptors and transporters - roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther 20, Suppl 7: 3-14, 2004.
12. Gershon MD. Enteric serotonergic neurones finally! J Physiol 587: 507, 2009.
13. Gershon MD, Drakontides AB, Ross LL. Serotonin synthesis and release from the myenteric plexus of the mouse intestine. Science 149: 197-199, 1965.
14. Gershon MD, Dreyfus CF. Stimulation of tryptophan uptake into enteric neurons by 5-hydroxytryptamine: a novel form of neuromodulation. Brain Res 184: 229-233, 1980.
15. Gershon M, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132: 397-414, 2007.
16. Goddard AW, Charney DS, Germine M, Woods SW, Heninger GR, Krystal JH, Goodman WK, Price LH. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biol Psychiatry 38: 74-85, 1995.
17. Hood S, Bell C, Nutt D. Acute tryptophan depletion. Part I: rationale and methodology. Aust NZ J Psychiatry 39: 558-564, 2005. (Pubitemid 41602540)
18. Janssen P, Prins NH, Moreaux B, Meulemans AL, Lefebvre RA. In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs. Br J Pharmacol 140: 913-920, 2003.
19. Janssen P, Van Oudenhove L, Casteels C, Vos R, Verbeke K, Tack J. Effect of acute citalopram treatment on gastric motor function and nutrient tolerence in healthy volunteers. Aliment Pharmacol Ther In Press.
20. Keszthelyi D, Troost FJ, Masclee AA. Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function. Neurogastroenterol Motil 21: 1239-1249, 2009.
21. Kilkens TO, Honig A, van Nieuwenhoven MA, Riedel WJ, Brummer RJ. Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls. Gut 53: 1794-1800, 2004.
22. Klaassen T, Klumperbeek J, Deutz NE, van Praag HM, Griez E. Effects of tryptophan depletion on anxiety and on panic provoked by carbon dioxide challenge. Psychiatry Res 77: 167-174, 1998.
23. Liu Q, Yang Q, Sun W, Vogel P, Heydorn W, Yu XQ, Hu Z, Yu W, Jonas B, Pineda R, Calderon-Gay V, Germann M, O'Neill E, Brommage R, Cullinan E, Platt K, Wilson A, Powell D, Sands A, Zambrowicz B, Shi ZC. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J Pharmacol Exp Ther 325: 47-55, 2008.
24. Michel K, Sann H, Schaaf C, Schemann M. Subpopulations of gastric myenteric neurons are differentially activated via distinct serotonin receptors: projection, neurochemical coding, and functional implications. J Neurosci 17: 8009-8017, 1997.
25. Michel K, Zeller F, Langer R, Nekarda H, Kruger D, Dover TJ, Brady CA, Barnes NM, Schemann M. Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors. Gastroenterology 128: 1317-1326, 2005.
26. 2-induced anxiety in patients with panic disorder and normal volunteers. Br J Psychiatry 176: 182-188, 2000.
27. Mortimore C, Connell J, Van F. Acute tryptophan depletion in healthy human subjects: effects on two anxiety paradigms. J Psychopharmacol 11, Suppl: A26, 1997.
28. Neal KB, Parry LJ, Bornstein JC. Strain-specific genetics, anatomy and function of enteric neural serotonergic pathways in inbred mice. J Physiol 587: 567-586, 2009.
29. Park SB, Coull JT, McShane RH, Young AH, Sahakian BJ, Robbins TW, Cowen PJ. Tryptophan depletion in normal volunteers produces selective impairments in learning and memory. Neuropharmacology 33: 575-588, 1994.
30. Peters JC. Tryptophan nutrition and metabolism: an overview. Adv Exp Med Biol 294: 345-358, 1991.
31. Raybould HE, Glatzle J, Robin C, Meyer JH, Phan T, Wong H, Sternini C. Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. Am J Physiol Gastrointest Liver Physiol 284: G367-G372, 2003.
32. Reilly JG, McTavish SFB, Young AH. Rapid depletion of plasma tryptophan: a review of studies and experimental methodology. J Psychopharmacol 11: 381-392, 1997.
33. Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E. The "normal" endocrine cell of the gut: changing concepts and new evidences. Ann NY Acad Sci 1014: 1-12, 2004.
34. Sarnelli G, Vos R, Cuomo R, Janssens J, Tack J. Reproducibility of gastric barostat studies in healthy controls and in dyspeptic patients. Am J Gastroenterol 96: 1047-1053, 2001.
35. Schnell FM. Chemotherapy-induced nausea and vomiting: the importance of acute antiemetic control. Oncologist 8: 187-198, 2003.
36. Shansis FM, Busnello JV, Quevedo J, Forster L, Young S, Izquierdo I, Kapczinski F. Behavioural effects of acute tryptophan depletion in healthy male volunteers. J Psychopharmacol 14: 157-163, 2000.
37. Smith KA, Clifford EM, Hockney RA, Clark DM, Cowen PJ. Effect of tryptophan depletion on mood in male and female volunteers: a pilot study. Hum Psychopharmacol 12: 111-117, 1997.
38. Smith SE, Pihl RO, Young SN, Ervin FR. A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psychopharmacology 91: 451-457, 1987.
39. Sobczak S, Riedel WJ, Booij I, Aab Het Rot M, Deutz NE, Honig A. Cognition following acute tryptophan depletion: difference between first-degree relatives of bipolar disorder patients and matched healthy control volunteers. Psychol Med 32: 503-515, 2002. (Pubitemid 34308794)
40. Spielberger C, Gorsuch R, Lushene R, Vagg P, Jacobs G. Manual for the State-Trait Anxiety Inventory (form Y self-evaluation questionnaire). Palo Alto, CA: Consulting Psychologists, 1983.
41. Tack J, Broekaert D, Coulie B, Fischler B, Janssens J. Influence of the selective serotonin reuptake inhibitor, paroxetine, on gastric sensorimotor function in humans. Aliment Pharmacol Ther 17: 603-608, 2003.
42. Tack J, Broeckaert D, Coulie B, Janssens J. The influence of cisapride on gastric tone and the perception of gastric distension. Aliment Pharmacol Ther 12: 761-766, 1998.
43. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 121: 526-535, 2001.
44. Tack J, Caenepeel P, Piessevaux H, Cuomo R, Janssens J. Assessment of meal induced gastric accommodation by a satiety drinking test in health and in severe functional dyspepsia. Gut 52: 791-796, 2003.
45. Tack J, Coulie B, Wilmer A, Andrioli A, Janssens J. Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man. Gut 46: 468-473, 2000.
46. Tack J, Demedts I, Meulemans A, Schuurkes J, Janssens J. Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans. Gut 51: 219-224, 2002.
47. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 115: 1346-1352, 1998.
48. Tack J, Sarnelli G. Serotonergic modulation of visceral sensation: upper gastrointestinal tract. Gut 51, Suppl 1: i77-i80, 2002.
49. Tack J, Vos R, Janssens J, Salter J, Jauffret S, Vandeplassche G. Influence of tegaserod on proximal gastric tone and on the perception of gastric distension. Aliment Pharmacol Ther 18: 1031-1037, 2003.
50. Van Nieuwenhoven MA, Valks SD, Sobczak S, Riedel WJ, Brummer RJ. Acute tryptophan depletion slows gastric emptying in females. Br J Nutr 91: 351-355, 2004.
51. Van Oudenhove L, Demyttenaere K, Tack J, Aziz Q. Central nervous system involvement in functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 18: 663-680, 2004.
52. Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299: 76, 2003.
53. Young SN, Smith SE, Pihl RO, Ervin FR. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology (Berl) 87: 173-177, 1985.
54. Yu PL, Fujimura M, Okumiya K, Kinoshita M, Hasegawa H, Fujimiya M. Immunohistochemical localization of tryptophan hydroxylase in the human and rat gastrointestinal tracts. J Comp Neurol 411: 654-665, 1999.
55. Zambrowicz B, Brown P, Jackson J, Frazier K, Clark E, Yang QM, Walke W, Freiman J, Powell D, Main AJ, Sands A. Serotonin biomarker levels correlate with clinical response in phase 2 trial of LX1031, a novel serotonin synthesis inhibitor for non-constipating IBS. Gastroenterology 138, Suppl 1: S-168, 2010.