A placebo-controlled trial of an oral capsaicin load in patients with functional dyspepsia

Neurogastroenterology and Motility

Volumn 23, Issue 10, 2011, Pages

  Fuhrer M ^a   Vogelsang, H ^a   Hammer, J ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Capsaicin; Chemical hypersensitivity; Functional dyspepsia; Sensation; Stomach

Indexed keywords

CAPSAICIN; PLACEBO;

ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DYSPEPSIA; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERSENSITIVITY; MAJOR CLINICAL STUDY; MALE; PERCEPTION; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; UPPER GASTROINTESTINAL TRACT;

ADMINISTRATION, ORAL; ADULT; CAPSAICIN; DOUBLE-BLIND METHOD; DYSPEPSIA; FEMALE; HUMANS; MALE; QUESTIONNAIRES; SENSORY SYSTEM AGENTS;

EID: 80052849225     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2011.01766.x     Document Type: Article

References (54)

1. Tack J, Talley NJ, Camilleri M et al. Functional gastroduodenal disorders. Gastroenterology 2006; 130: 1466-79.
2. Saad RJ, Chey WD. Review article: current and emerging therapies for functional dyspepsia. Aliment Pharmacol Ther 2006; 24: 475-92.
3. Mayer EA, Collins SM. Evolving pathophysiologic models of functional gastrointestinal disorders. Gastroenterology 2002; 122: 2032-48.
4. Kim DY, Myung SJ, Camilleri M. Novel testing of human gastric motor and sensory functions: rationale, methods, and potential applications in clinical practice. Am J Gastroenterol 2000; 95: 3365-73.
5. Keohane J, Quigley EMM. Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis. World J Gastroenterol 2006; 12: 2672-6.
6. Camilleri M, Coulie B, Tack JF. Visceral hypersensitivity. Facts, speculations, challenges. Gut 2001; 48: 125-31.
7. Tack J. Chemosensitivity of the human gastrointestinal tract in health and in disease. Neurogastroenterol Motil 2007; 19: 241-4.
8. George AA, Tsuchiyose M, Dooley CP. Sensitivity of the gastric mucosa to acid and duodenal contents in patients with nonulcer dyspepsia. Gastroenterology, 1991; 101: 3-6.
9. Grundy D, Scratchered T. Sensory afferents from the gastrointestinal tract. In: Schultz SG, Wodd JD, Rauner BR eds. Handbook of Physiology. Section 6: The Gastrointestinal System. Bethesda: American Physical Society, 1989: 593-620.
10. Schmidt B, Hammer J, Holzer P, Hammer HF. Chemical nociception in the jejunum induced by capsaicin. Gut, 2004; 53: 1109-16.
11. Hammer J, Vogelsang H. Characterisation of sensations induced by capsaicin in the upper gastrointestinal tract. Neurogastroenterol Motil 2007; 19: 279-87.
12. Lee KJ, Vos R, Tack J. Effects of capsaicin on the sensorimotor function of the proximal stomach in humans. Aliment Pharmacol Ther 2004; 19: 415-25.
13. Hammer J. Hyperalgesia against capsaicin in subjects with uninvestigated dyspepsia: potential as a new diagnostic test. Wien Klin Wochensch 2006; 118: 43-8.
14. Hammer J, Führer M, Pipal L, Matiasek J. Hypersensitivity for capsaicin in patients with functional dyspepsia. Neurogastroenterol Motil 2008; 20: 125-33.
15. Mertz H, Fullerton S, Naliboff B, Mayer EA. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut 1998; 42: 814-22.
16. Silverman DH, Munakata JA, Ennes H, Mandelkern MA, Hoh CK, Mayer EA. Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology 1997; 112: 64-72.
17. Mayer EA. Spinal and supraspinal modulation of visceral sensation. Gut 2000; 47: 69-72.
18. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GNJ. Functional gastroduodenal disorders. Gut 1999; 45(Suppl. II): 37-42.
19. Hammer J, Eslick GD, Howell SC, Altiparmak E, Talley NJ. Diagnostic yield of alarm features in irritable bowel syndrome and functional dyspepsia. Gut 2004; 53: 666-72.
20. Führer M, Hammer J. Effect of repeated, long term capsaicin ingestion on intestinal chemo- and mechanosensation in healthy volunteers. Neurogastroenterol Motil 2009; 21: 521-7.
21. Hammer J. Effect of repeated capsaicin ingestion on intestinal chemo- and mechanosensation. Aliment Pharmacol Ther 2006; 24: 679-86.
22. Accarino AM, Azpiroz F, Malagelada J-R. Gut perception in humans is modulated by interacting gut stimuli. Am J Physiol Gastrointest Liver Physiol 2002; 282: G220-5.
23. Hammer J, Führer M. Intestinal chemo- and mechanosensitivity: selective modification of small intestinal sensitivity by lipids. Aliment Pharmacol Ther 2007; 26: 117-24.
24. Führer M, Hammer J. Duodenal chemosensitivity and mechanosensitivity during acid and ethanol perfusion. Europ J Gastroenterol Hepatol 2008; 20: 537-44.
25. Wilson EB. Probable inference, the law of succession, and statistical inference. J Am Stat Assoc 1927; 22: 209-12.
26. Simel DL, Samsa GP, Matchar DB. Likelihood ratios with confidence: sample size estimation for diagnostic test studies. J Clinical Epidemiol 1991; 44: 763-70.
27. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Symptoms associated with hypersensitivity to gastric distension in functional dyspepsia. Gastroenterology 2001; 121: 526-35.
28. Van Oudenhove L, Vandenberghe J, Geeraerts B et al. Relationship between anxiety and gastric sensorimotor function in functional dyspepsia. Psychosom Med 2007; 69: 455-63.
29. De Schepper HU, Cremonini F, Chitkara D, Camilleri M. Assessment of gastric accommodation: overview and evaluation of current methods. Neurogastroenterol Motil 2004; 16: 275-85.
30. Brock C, Arendt-Nielsen L, Wilder-Smith O, Drewes AM. Sensory testing of the human gastrointestinal tract. World J Gastroenterol 2009; 15: 151-9.
31. Papadopoulos V, Fragaki M, Mimidis K. Paired comparison between water and nutrient drink tests in healthy volunteers. Arq Gastroenterol 2009; 46: 304-10.
32. Talley NJ, Choung RS, Camilleri M, Dierkhising RA, Zinsmeister AR. Asimadoline, a kappa-opioid agonist, and satiation in functional dyspepsia. Aliment Pharmacol Ther 2008; 27: 1122-31.
33. Bouras EP, Talley NJ, Camilleri M et al. Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-controlled trial. Am J Gastroenterol 2008; 103: 2043-50.
34. Mayer EA. The challenge of studying the biology of complex, symptom-based GI disorders. Gastroenterology 2008; 134: 1826-7.
35. Mayer EA, Bradesi S, Chang L, Spiegel BMR, Bueller JA, Naliboff BD. Functional GI disorders: from animal models to drug development. Gut 2008; 57: 384-404.
36. Saito YA, Mitra N, Mayer EA. Genetic approaches to functional gastrointestinal disorders. Gastroenterology 2010; 138: 1276-85.
37. Holtmann G, Gapasin J. Failed therapy and directions for the future in dyspepsia. Dig Dis 2008; 26: 218-24.
38. Holzer P. TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia. Eur J Pharmacol 2004; 500: 231-41.
39. Geppetti P, Trevisani M. Activation and sensation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol 2004; 141: 1313-20.
40. Blackshaw LA, Brierley SM, Hughes PA. TRP channels: new targets for visceral pain. Gut 2010; 59: 126-35.
41. Akbar A, Yiangou Y, Facer P, Walters JRF, Anand P, Ghosh S. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut 2008; 57: 923-9.
42. Akbar A, Yiangou Y, Facer P et al. Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain. Gut 2010; 59: 767-74.
43. Tahara T, Shibata T, Nakamura M et al. Homozygous TRPV1 315C influences the susceptibility to functional dyspepsia. J Clin Gastroenterol 2010; 44: e1-7.
44. Hammer J, Hammer HF, Eherer AJ, Petritsch W, Holzer P, Krejs GJ. Intraluminal capsaicin does not affect fluid and electrolyte absorption in the human jejunum but causes pain. Gut 1998; 43: 252-5.
45. Stanghellini V, Tosetti C, Paternico A et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996; 110: 1036-42.
46. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998; 115: 1346-52.
47. Halder SL, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ. Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study. Gastroenterology 2007; 133: 799-807.
48. Hammer J, Führer M. Perception dynamics after ingestion of capsaicin in healthy volunteers versus patients with functional dyspepsia. Gut 2009; 58(Suppl. II): A185.
49. Coen SJ, Aziz Q, Yágüez L, Brammer M, Williams SC, Gregory LJ. Effects of attention on visceral stimulus intensity encoding in the male human brain. Gastroenterology 2008; 135: 2065-74.
50. Posserud I, Svedlund J, Wallin J, Simrén M. Hypervigilance in irritable bowel syndrome compared with organic gastrointestinal disease. J Psychosom Res 2009; 66: 399-405.
51. Bradesi S, Herman J, Mayer EA. Visceral analgesics: drugs with a great potential in functional disorders? Curr Opin Pharmacol 2008; 8: 697-703.
52. Bratten J, Jones MP. New directions in the assessment of gastric function: clinical application of physiologic measurements. Dig Dis 2006; 24: 252-9.
53. Gharat LA, Szallasi A. Advances in the design and therapeutic use of capsaicin receptor TRPV1 agonists and antagonists. Expert Opin Ther patents 2008; 18: 159-209.
54. Holzer P. The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol 2008; 155: 1145-62.