The influence of cisapride on gastric tone and the perception of gastric distension

Alimentary Pharmacology and Therapeutics

Volumn 12, Issue 8, 1998, Pages 761-766

  Tack, J ^a   Broeckaert, D ^a   Coulie, B ^a   Janssens, J ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CISAPRIDE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STOMACH DISTENSION; STOMACH EMPTYING; STOMACH FUNDUS; STOMACH PRESSURE;

ADULT; CISAPRIDE; DYSPEPSIA; FEMALE; GASTRIC EMPTYING; GASTRIC FUNDUS; GASTROINTESTINAL AGENTS; HUMANS; MALE; PERCEPTION; POSTPRANDIAL PERIOD;

EID: 0031876343     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1998.00366.x     Document Type: Article

References (20)

1. Drossman DA, Thompson WG, Talley NJ, Funch-Jensen P, Janssens J, Whitehead WE. Identifications of subgroups of functional gastrointestinal disorders. Gastroenterol Int 1990; 3: 159-72.
2. Talley NJ, Phillips SF. Non-ulcer dyspepsia: potential causes and pathophysiology. Ann Intern Med 1988; 108: 865-79.
3. Stanghellini V, Tosetti C, Paternico A, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996; 110: 1036-42.
4. Camilleri M, Brown ML, Malagelada JR. Relationship between impaired gastric emptying and abnormal gastrointestinal motility. Gastroenterology 1986; 91: 94-9.
5. Jian R, Ducrot F, Ruskone A, Chaussade S, Rambaud JC, Modigliani R. Symptomatic radionuclide and therapeutic assessment of chronic idiopathic dyspepsia. A double-blind placebo-controlled evaluation of cisapride. Dig Dis Sci 1989; 34: 657-64.
6. Mearin F, Cucala M, Azpiroz F, Malagelada JR. The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology 1991; 101: 999-1006.
7. Bradette M, Pare P, Douville P, Morin A. Visceral perception in health and functional dyspepsia. Crossover study of gastric distensions with placebo and domperidone. Dig Dis Sci 1991; 56: 52-8.
8. Troncon LEA, Bennett RJM, Ahluwalia NK, Thompson DG. Abnormal distribution of food during gastric emptying in functional dyspepsia patients. Gut 1994; 35: 327-32.
9. Gilja OH, Hausken T, Wilhelmsen I, Berstad A. Impaired accommodation of proximal stomach to a meal in functional dyspepsia. Dig Dis Sci 1996; 41: 689-96.
10. Hollmann G, Talley NJ. Functional dyspepsia. Current treatment recommendations. Drugs 1993; 45: 918-30.
11. Tack J, Coremans G, Janssens J. A risk-benefit assessment of cisapride in the treatment of gastrointestinal disorders. Drug Safety 1995; 12: 384-92.
12. Maes BD, Ghoos YF, Hiele MI, Rutgeerts PJ. Gastric emptying rate of solids in patients with nonulcer dyspepsia. Dig Dis Sci 1997; 42: 1158-62.
13. Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada JR. Gastric tone determines the sensitivity of the stomach to distension. Gastroenterology 1995; 108: 330-6.
14. Tack J, Piessevaux H, Coulie B, Caenepeel P, Janssens J. In functional dyspepsia, impaired gastric accommodation is associated with early satiety and weight loss. Neurogastroenterol Motil 1998; 10: A102 (Abstract).
15. Azpiroz F, Malagelada JR. Vagally mediated gastric relaxation induced by intestinal nutrients in the dog. Am J Physiol 1986; 251: G727-35.
16. De Ponti F, Azpiroz F, Malagelada JR. Reflex gastric relaxation in response to distension of the duodenum. Am J Physiol 1987; 252: G595-601.
17. Desai KM, Sessa WC, Vane JR. Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid. Nature 1991; 35: 477-9.
18. Schuurkes JAJ, Helsen LF, Meulemans AL. In the presence of atropine, cisapride induces NO-mediated gastric relaxation. Gastroenterology 1995; 108: A686 (Abstract).
19. Hausken T, Berstad A. Wide gastric antrum in patients with non-ulcer dyspepsia. Effect of cisapride. Scand J Gastroenterol 1992; 27: 427-32.
20. Rosch W. Efficacy of cisapride in the treatment of epigastric pain and concomitant symptoms in non-ulcer dyspepsia. Scand J Gastroenterol 1989; 165 (Suppl.): 54-8.