Endocannabinoid control of gastric sensorimotor function in man

Alimentary Pharmacology and Therapeutics

Volumn 31, Issue 10, 2010, Pages 1123-1131

  Ameloot, K ^a   Janssen, P ^a   Scarpellini, E ^a   Vos, R ^a   Boesmans, W ^a   Depoortere, I ^a   Vanden Berghe, P ^a   Tack, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR ANTAGONIST; ENDOCANNABINOID; PLACEBO; RIMONABANT; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AFFECTING AGENT; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

ADULT; ARTICLE; BAROSTAT; CLINICAL TRIAL; COMPLIANCE (PHYSICAL); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUTRIENT; PRIORITY JOURNAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SATIETY; SENSORIMOTOR FUNCTION; STOMACH DISTENSION; STOMACH FUNCTION; STOMACH MOTILITY; VOLUNTEER; ADOLESCENT; AGED; DRUG EFFECTS; EATING; GASTROINTESTINAL MOTILITY; MIDDLE AGED; PHYSIOLOGY; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CANNABINOID RECEPTOR MODULATORS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EATING; ENDOCANNABINOIDS; FEMALE; GASTROINTESTINAL MOTILITY; HUMANS; MALE; MIDDLE AGED; PIPERIDINES; PYRAZOLES; RECEPTORS, CANNABINOID; SATIATION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77951225636     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2010.04259.x     Document Type: Article

References (27)

1. Pertwee RG. Cannabinoids and the gastrointestinal tract. Gut 2001 48 : 859 867.
2. Duncan M, Davison JS, Sharkey KA. Review article: endocannabinoids and their receptors in the enteric nervous system. Aliment Pharmacol Ther 2005 22 : 667 683.
3. Hornby PJ, Prouty SM. Involvement of cannabinoid receptors in gut motility and visceral perception. Br J Pharmacol 2004 141 : 1335 1345.
4. Boesmans W, Ameloot K, van den Abbeel V, Tack J, Vanden Berghe P. Cannabinoid receptor 1 signalling dampens activity and mitochondrial transport in networks of enteric neurones. Neurogastroenterol Motil 2009 21 : 958 e77.
5. McCallum RW, Soykan I, Plankey W, et al. Delta-9-tetrahydrocannabinol delays the gastric emptying of solid food in humans: a double blind, randomized study. Aliment Pharmacol Ther 1999 13 : 77 80.
6. Casu MA, Porcella A, Ruiu S, et al. Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract. Eur J Pharmacol 2003 459 : 97 105.
7. Izzo A, Pinto L, Borrelli F, et al. Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil. B Jour Pharmacol 2000 129 : 1627 1632.
8. Walker JM, Huang SM. Endocannabinoids and pain modulation. Prostaglandin Leukot Essent fatty acids 2002 66 : 235 242.
9. Currioni C, Andre C. Rimonabant for overweight or obesity. Cochrane Database Syst Rev 2006 CD006162 : 1 56.
10. Carai M, Colombo G, Maccioni P, et al. Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight : preclinical and clinical data. CNS drug reviews 2006 12 : 91 9.
11. Akbas F, Gasteyger C, Larsen M, et al. A critical review of the cannabinoid receptor as a drug target for obesity management. Obesity reviews 2008 10 : 58 67.
12. Tack J, Piessevaux H, Coulie B, et al. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998 115 : 1346 1352.
13. Tack J, Caenepeel P, Fischler B, Piessevaux H, Janssens J. Hypersensitivity to gastric distention is associated with symptoms in functional dyspepsia. Gastroenterology 2001 121 : 526 535.
14. Tack J, Jones MP, Karamanolis G, Coulie B, Dubois D. Symptom pattern and pathophysiological correlates of weight loss in tertiary-referred functional dyspepsia. Neurogastroenterol Motil 2010 22 : 29 e5.
15. Ball AJ, Moerschbaecher JM, Hornby PJ. Delta-9-tetrahydrocannabinol effects on gastric motility are mediated by a capsacin-sensitive vagal pathway. Digestion 2001 63 : 269.
16. Gomez R, Navarro M, Ferrer B. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 2002 22 : 9612 9617.
17. Kindt S, Tack J. Impaired gastric accommodation and its role in dyspepsia. Gut 2006 55 : 1685 1691.
18. Landi M, Croci T, Manara L. Modulation of gastric emptying and gastrointestinal transit in rats through intestinal cannabinoid CB1 receptors. Eur Jour Pharmacol 2002 450 : 77 83.
19. Krowicki ZK, Moerschbaecher JM, Winsauer PJ, et al. ΔTHC inhibits gastric motility in the rat through cannabinoid CB1 receptors. Eur J Pharmacol 1999 371 : 187 196.
20. Tack J, Demedts I, Meulemans A, et al. Role of nitric oxide in the gastric accommodation reflex and in meal induced satiety in humans. Gut 2002 51 : 219 224.
21. Van Oudenhove L, Kindt S, Vos R, Coulie B, Tack J. Influence of buspirone on gastric sensorimotor function in man. Aliment Pharmacol Ther 2008 28 : 1326 1333.
22. Storr M, Gaffal E, Allescher HD, et al. Effects of cannabinoids on neural transmission in rat gastric fundus. Can J Physiol Pharmacol 2002 80 : 67 76. (Pubitemid 34194288)
23. Hienemann A, Shahbazian A, Holzer P. Cannabinoid inhibition of guinea-pig intestinal peristalsis via inhibition of excitatory and activation of inhibitory neural pathways. Neuropharmacology 1999 38 : 1289 1297.
24. Cuomo R, Vandaele P, Coulie B, et al. Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways. Am J Gastroenterol 2006 101 : 804 811.
25. Tack J, Caenepeel P, Piessevaux H, Cuomo R, Janssens J. Assessment of meal-induced gastric accommodation by a satiety drinking test in health and in functional dyspepsia. Gut 2003 52 : 1271 1277.
26. Tack J, Caenepeel P, Corsetti M, et al. Role of tension receptors in dyspeptic patients with hypersensitivity to gastric distention. Gastroenterology 2004 127 : 1058 1066.
27. Engeli S, Bohnke J, Jordan J, et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes 2005 54 : 2838 2843.