Tonic inhibition by G Protein-Coupled receptor Kinase 2 of Akt/Endothelial Nitric-Oxide synthase signaling in human vascular endothelial cells under conditions of Hyperglycemia with high insulin levels

Journal of Pharmacology and Experimental Therapeutics

Volumn 349, Issue 2, 2014, Pages 199-208

  Taguchi, Kumiko ^a   Sakata, Kimimasa ^a   Ohashi, Wakana ^a   Imaizumi, Takahiro ^a   Imura, Joji ^a   Hattori, Yuichi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; G PROTEIN COUPLED RECEPTOR KINASE 2; GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; EMBRYO; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MOLECULAR PATHOLOGY; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ARRESTINS; DIABETES MELLITUS; ENDOTHELIUM, VASCULAR; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GLUCOSE; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INSULIN; INSULIN RESISTANCE; NITRIC OXIDE SYNTHASE TYPE III; NITROFURANS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VINYL COMPOUNDS;

EID: 84898781405     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.113.211854     Document Type: Article

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