An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

eLife

Volumn 2014, Issue 3, 2014, Pages

  MacKinnon, Andrew L ^a   Paavilainen, Ville O ^a   Sharma, Ajay ^b   Hegde, Ramanujan S ^b,d   Taunton, Jack ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA ANTIBODY; COTRANSIN; CROSS LINKING REAGENT; CYCLOPEPTIDE; MEMBRANE PROTEIN; PROTEIN BINDING; SEC61A1 PROTEIN, HUMAN; SEC61G PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

ALLOSTERISM; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DNA SEQUENCE; GENE MUTATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MICROSOME; MOLECULAR DOCKING; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY; TRANSLATION REGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL MEMBRANE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HCT116 CELL LINE; HEK293 CELL LINE; METABOLISM; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CELL MEMBRANE; CROSS-LINKING REAGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HCT116 CELLS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MOLECULAR DOCKING SIMULATION; MUTATION; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84898761276     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.01483     Document Type: Article

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