Antiporters of the mitochondrial carrier family

Current Topics in Membranes

Volumn 73, Issue , 2014, Pages 289-320

  Monné, Magnus ^a,b   Palmieri, Ferdinando ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF BASILICATA   (Italy)

Author keywords

Antiporter; Membrane transport; Mitochondria; Mitochondrial carrier; SLC25 family; Transport mechanism; Transporter

Indexed keywords

ANTIPORTER; CARRIER PROTEIN;

ANIMAL; HUMAN; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTIPORTERS; BIOLOGICAL TRANSPORT; HUMANS; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS;

EID: 84898639346     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800223-0.00008-6     Document Type: Chapter

References (154)

1. Agrimi G., Di Noia M.A., Marobbio C.M.T., Fiermonte G., Lasorsa F.M., Palmieri F. Identification of the human mitochondrial S-adenosylmethionine transporter: Bacterial expression, reconstitution, functional characterization and tissue distribution. Biochemical Journal 2004, 379:183-190.
2. Agrimi G., Russo A., Pierri C.L., Palmieri F. The peroxisomal NAD(+) carrier of Arabidopsis thaliana transports coenzyme A and its derivatives. Journal of Bioenergetics and Biomembranes 2012, 44:333-340.
3. Agrimi G., Russo A., Scarcia P., Palmieri F. The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. Biochemical Journal 2012, 443:241-247.
4. Amutha B., Pain D. Nucleoside diphosphate kinase of Saccharomyces cerevisiae, Ynk1p: Localization to the mitochondrial intermembrane space. Biochemical Journal 2003, 370:805-815.
5. Aprille J.R. Mechanism and regulation of the mitochondrial ATP-Mg/P(i) carrier. Journal of Bioenergetics and Biomembranes 1993, 25:473-481.
6. Aquila H., Eiermann W., Babel W., Klingenberg M. Isolation of the ADP/ATP translocator from beef heart mitochondria as the bongkrekate-protein complex. European Journal of Biochemistry 1978, 85:549-560.
7. Bamber L., Harding M., Butler P.J.G., Kunji E.R.S. Yeast mitochondrial ADP/ATP carriers are monomeric in detergents. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:16224-16229.
8. Bamber L., Harding M., Monné M., Slotboom D.-J., Kunji E.R.S. The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:10830-10834.
9. Bamber L., Slotboom D.-J., Kunji E.R.S. Yeast mitochondrial ADP/ATP carriers are monomeric in detergents as demonstrated by differential affinity purification. Journal of Molecular Biology 2007, 371:388-395.
10. Bisaccia F., Capobianco L., Brandolin G., Palmieri F. Transmembrane topography of the mitochondrial oxoglutarate carrier assessed by peptide-specific antibodies and enzymatic cleavage. Biochemistry 1994, 33:3705-3713.
11. Bisaccia F., De Palma A., Dierks T., Krämer R., Palmieri F. Reaction mechanism of the reconstituted tricarboxylate carrier from rat liver mitochondria. Biochimica et Biophysica Acta 1993, 1142:139-145.
12. Bisaccia F., De Palma A., Palmieri F. Identification and purification of the tricarboxylate carrier from rat liver mitochondria. Biochimica et Biophysica Acta 1989, 977:171-176.
13. Bisaccia F., De Palma A., Prezioso G., Palmieri F. Kinetic characterization of the reconstituted tricarboxylate carrier from rat liver mitochondria. Biochimica et Biophysica Acta 1990, 1019:250-256.
14. Bisaccia F., Indiveri C., Palmieri F. Purification of reconstitutively active alpha-oxoglutarate carrier from pig heart mitochondria. Biochimica et Biophysica Acta 1985, 810:362-369.
15. Bisaccia F., Zara V., Capobianco L., Iacobazzi V., Mazzeo M., Palmieri F. The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier. Biochimica et Biophysica Acta 1996, 1292:281-288.
16. Block M.R., Vignais P.V. Substrate-site interactions in the membrane-bound adenine-nucleotide carrier as disclosed by ADP and ATP analogs. Biochimica et Biophysica Acta 1984, 767:369-376.
17. Block M.R., Zaccaï G., Lauquin G.J., Vignais P.V. Small angle neutron scattering of the mitochondrial ADP/ATP carrier protein in detergent. Biochemical and Biophysical Research Communications 1982, 109:471-477.
18. Bouvier F., Linka N., Isner J.-C., Mutterer J., Weber A.P.M., Camara B. Arabidopsis SAMT1 defines a plastid transporter regulating plastid biogenesis and plant development. Plant Cell 2006, 18:3088-3105.
19. Brandolin G., Doussiere J., Gulik A., Gulik-Krzywicki T., Lauquin G.J., Vignais P.V. Kinetic, binding and ultrastructural properties of the beef heart adenine nucleotide carrier protein after incorporation into phospholipid vesicles. Biochimica et Biophysica Acta 1980, 592:592-614.
20. Brandolin G., Dupont Y., Vignais P.V. Substrate-induced modifications of the intrinsic fluorescence of the isolated adenine nucleotide carrier protein: Demonstration of distinct conformational states. Biochemistry 1985, 24:1991-1997.
21. Briggs C., Mincone L., Wohlrab H. Replacements of basic and hydroxyl amino acids identify structurally and functionally sensitive regions of the mitochondrial phosphate transport protein. Biochemistry 1999, 38:5096-5102.
22. Brustovetsky N., Becker A., Klingenberg M., Bamberg E. Electrical currents associated with nucleotide transport by the reconstituted mitochondrial ADP/ATP carrier. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:664-668.
23. Buchanan B.B., Eiermann W., Riccio P., Aquila H., Klingenberg M. Antibody evidence for different conformational states of ADP, ATP translocator protein isolated from mitochondria. Proceedings of the National Academy of Sciences of the United States of America 1976, 73:2280-2284.
24. Capobianco L., Bisaccia F., Michel A., Sluse F.E., Palmieri F. The N- and C-termini of the tricarboxylate carrier are exposed to the cytoplasmic side of the inner mitochondrial membrane. FEBS Letters 1995, 357:297-300.
25. Capobianco L., Brandolin G., Palmieri F. Transmembrane topography of the mitochondrial phosphate carrier explored by peptide-specific antibodies and enzymatic digestion. Biochemistry 1991, 30:4963-4969.
26. Cappello A.R., Curcio R., Valeria Miniero D., Stipani I., Robinson A.J., Kunji E.R.S., et al. Functional and structural role of amino acid residues in the even-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier. Journal of Molecular Biology 2006, 363:51-62.
27. Cappello A.R., Miniero D.V., Curcio R., Ludovico A., Daddabbo L., Stipani I., et al. Functional and structural role of amino acid residues in the odd-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier. Journal of Molecular Biology 2007, 369:400-412.
28. Castegna A., Scarcia P., Agrimi G., Palmieri L., Rottensteiner H., Spera I., et al. Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in S. cerevisiae. Journal of Biological Chemistry 2010, 285:17359-17370.
29. Cavero S., Vozza A., Del Arco A., Palmieri L., Villa A., Blanco E. Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae. Molecular Microbiology 2003, 50:1257-1269.
30. Crichton P.G., Harding M., Ruprecht J.J., Lee Y., Kunji E.R.S. Lipid, detergent and Coomassie dye affect the migration of small membrane proteins in blue native gels: Mitochondrial carriers migrate as monomers not dimers. Journal of Biological Chemistry 2013, 288:22163-22173.
31. Dehez F., Pebay-Peyroula E., Chipot C. Binding of ADP in the mitochondrial ADP/ATP carrier is driven by an electrostatic funnel. Journal of the American Chemical Society 2008, 130:12725-12733.
32. De Lucas J.R., Indiveri C., Tonazzi A., Perez P., Giangregorio N., Iacobazzi V., et al. Functional characterization of residues within the carnitine/acylcarnitine translocase RX2PANAAXF distinct motif. Molecular Membrane Biology 2008, 25:152-163.
33. De Marcos Lousa C., Trézéguet V., Dianoux A.-C., Brandolin G., Lauquin G.J.-M. The human mitochondrial ADP/ATP carriers: Kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae. Biochemistry 2002, 41:14412-14420.
34. Dierks T., Riemer E., Krämer R. Reaction mechanism of the reconstituted aspartate/glutamate carrier from bovine heart mitochondria. Biochimica et Biophysica Acta 1988, 43:231-244.
35. Dolce V., Iacobazzi V., Palmieri F., Walker J.E. The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms. Journal of Biological Chemistry 1994, 269:10451-10460.
36. Dolce V., Scarcia P., Iacopetta D., Palmieri F. A fourth ADP/ATP carrier isoform in man: Identification, bacterial expression, functional characterization and tissue distribution. FEBS Letters 2005, 579:633-637.
37. Endres M., Neupert W., Brunner M. Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex. EMBO Journal 1999, 18:3214-3221.
38. Falconi M., Chillemi G., Di Marino D., D'Annessa I., Morozzo della Rocca B., Palmieri L., et al. Structural dynamics of the mitochondrial ADP/ATP carrier revealed by molecular dynamics simulation studies. Proteins 2006, 65:681-691.
39. Fiermonte G., De Leonardis F., Todisco S., Palmieri L., Lasorsa F.M., Palmieri F. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution. Journal of Biological Chemistry 2004, 279:30722-30730.
40. Fiermonte G., Dolce V., David L., Santorelli F.M., Dionisi-Vici C., Palmieri F., et al. The mitochondrial ornithine transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. Journal of Biological Chemistry 2003, 278:32778-32783.
41. Fiermonte G., Dolce V., Palmieri F. Expression in Escherichia coli, functional characterization, and tissue distribution of isoforms A and B of the phosphate carrier from bovine mitochondria. Journal of Biological Chemistry 1998, 273:22782-22787.
42. Fiermonte G., Dolce V., Palmieri L., Ventura M., Runswick M.J., Palmieri F., et al. Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location. Journal of Biological Chemistry 2001, 276:8225-8230.
43. Fiermonte G., Palmieri L., Dolce V., Lasorsa F.M., Palmieri F., Runswick M.J., et al. The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. Journal of Biological Chemistry 1998, 273:24754-24759.
44. Fiermonte G., Palmieri L., Todisco S., Agrimi G., Palmieri F., Walker J.E. Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms. Journal of Biological Chemistry 2002, 277:19289-19294.
45. Fiermonte G., Paradies E., Todisco S., Marobbio C.M.T., Palmieri F. A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. Journal of Biological Chemistry 2009, 284:18152-18159.
46. Fiermonte G., Walker J.E., Palmieri F. Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria. Biochemical Journal 1993, 294:293-299.
47. Floyd S., Favre C., Lasorsa F.M., Leahy M., Trigiante G., Stroebel P., et al. The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Molecular Biology of the Cell 2007, 18:3545-3555.
48. Giangregorio N., Tonazzi A., Console L., Indiveri C., Palmieri F. Site-directed mutagenesis of charged amino acids of the human mitochondrial carnitine/acylcarnitine carrier: Insight into the molecular mechanism of transport. Biochimica et Biophysica Acta 2010, 1797:839-845.
49. Gordon D.M., Lyver E.R., Lesuisse E., Dancis A., Pain D. GTP in the mitochondrial matrix plays a crucial role in organellar iron homoeostasis. Biochemical Journal 2006, 400:163-168.
50. Gropp T., Brustovetsky N., Klingenberg M., Müller V., Fendler K., Bamberg E. Kinetics of electrogenic transport by the ADP/ATP carrier. Biophysical Journal 1999, 77:714-726.
51. Hackenberg H., Klingenberg M. Molecular weight and hydrodynamic parameters of the adenosine 5'-diphosphate-Adenosine 5'-triphosphate carrier in Triton X-100. Biochemistry 1980, 19:548-555.
52. Heidkämper D., Müller V., Nelson D.R., Klingenberg M. Probing the role of positive residues in the ADP/ATP carrier from yeast. The effect of six arginine mutations on transport and the four ATP versus ADP exchange modes. Biochemistry 1996, 35:16144-16152.
53. Hoyos M.E., Palmieri L., Wertin T., Arrigoni R., Polacco J.C., Palmieri F. Identification of a mitochondrial transporter for basic amino acids in Arabidopsis thaliana by functional reconstitution into liposomes and complementation in yeast. Plant Journal 2003, 33:1027-1035.
54. Huizing M., Ruitenbeek W., van den Heuvel L.P., Dolce V., Iacobazzi V., Smeitink J.A. Human mitochondrial transmembrane metabolite carriers: Tissue distribution and its implication for mitochondrial disorders. Journal of Bioenergetics and Biomembranes 1998, 30:277-284.
55. Iacobazzi V., Naglieri M.A., Stanley C.A., Wanders R.J., Palmieri F. The structure and organization of the human carnitine/acylcarnitine translocase (CACT1) gene2. Biochemical and Biophysical Research Communications 1998, 252:770-774.
56. Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E. Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier. DNA Sequence 1992, 3:79-88.
57. Iijima M., Jalil A., Begum L., Yasuda T., Yamaguchi N., Xian Li M., et al. Adult-onset type II cintrullinemia. Advances in Enzyme Regulation 2001, 41:325-342.
58. Indiveri C., Dierks T., Krämer R., Palmieri F. Reaction mechanism of the reconstituted oxoglutarate carrier from bovine heart mitochondria. European Journal of Biochemistry 1991, 198:339-347.
59. Indiveri C., Iacobazzi V., Tonazzi A., Giangregorio N., Infantino V., Convertini P. The mitochondrial carnitine/acylcarnitine carrier: Function, structure and physiopathology. Molecular Aspects of Medicine 2011, 32:223-233.
60. Indiveri C., Krämer R., Palmieri F. Reconstitution of the malate/aspartate shuttle from mitochondria. Journal of Biological Chemistry 1987, 262:15979-15983.
61. Indiveri C., Palmieri F., Bisaccia F., Krämer R. Kinetics of the reconstituted 2-oxoglutarate carrier from bovine heart mitochondria. Biochimica et Biophysica Acta 1987, 890:310-318.
62. Indiveri C., Prezioso G., Dierks T., Krämer R., Palmieri F. Kinetic characterization of the reconstituted dicarboxylate carrier from mitochondria: A four-binding-site sequential transport system. Biochimica et Biophysica Acta 1993, 1143:310-318.
63. Indiveri C., Tonazzi A., De Palma A., Palmieri F. Kinetic mechanism of antiports catalyzed by reconstituted ornithine/citrulline carrier from rat liver mitochondria. Biochimica et Biophysica Acta 2001, 1503:303-313.
64. Indiveri C., Tonazzi A., Palmieri F. Identification and purification of the carnitine carrier from rat liver mitochondria. Biochimica et Biophysica Acta 1990, 1020:81-86.
65. Indiveri C., Tonazzi A., Palmieri F. Characterization of the unidirectional transport of carnitine catalyzed by the reconstituted carnitine carrier from rat liver mitochondria. Biochimica et Biophysica Acta 1991, 1069:110-116.
66. Indiveri C., Tonazzi A., Palmieri F. The reconstituted carnitine carrier from rat liver mitochondria: Evidence for a transport mechanism different from that of the other mitochondrial translocators. Biochimica et Biophysica Acta 1994, 1189:65-73.
67. Indiveri C., Tonazzi A., Prezioso G., Palmieri F. Kinetic characterization of the reconstituted carnitine carrier from rat liver mitochondria. Biochimica et Biophysica Acta 1991, 1065:231-238.
68. Kadenbach B., Mende P., Kolbe H.V., Stipani I., Palmieri F. The mitochondrial phosphate carrier has an essential requirement for cardiolipin. FEBS Letters 1982, 139:109-112.
69. Kao L.R., Megraw T.L., Chae C.B. SHM1: A multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene. Yeast 1996, 12:1239-1250.
70. Kaplan R., Mayor J., Gremse D. High level expression and characterization of the mitochondrial citrate transport protein from the yeast Saccharomyces cerevisiae. Journal of Biological Chemistry 1995, 270:4108-4114.
71. Kaplan R.S., Mayor J.A., Johnston N., Oliveira D.L. Purification and characterization of the reconstitutively active tricarboxylate transporter from rat liver mitochondria. Journal of Biological Chemistry 1990, 265:13379-13385.
72. Klingenberg M. The ADP-ATP carrier in mitochondrial membranes. The enzymes of biological membranes 1976, Vol. 3:383-438. Plenum Press, New York. A.N. Martonosi (Ed.).
73. Klingenberg M. The ADP, ATP shuttle of the mitochondrion. Trends in Biochemical Sciences 1979, 4:249-252.
74. Klingenberg M. The ADP and ATP transport in mitochondria and its carrier. Biochimica et Biophysica Acta 2008, 1778:1978-2021.
75. Klingenberg M., Buchholz M. On the mechanism of bongkrekate effect on the mitochondrial adenine-nucleotide carrier as studied through the binding of ADP. European Journal of Biochemistry 1973, 38:346-358.
76. Klingenberg M., Winkler E. The reconstituted isolated uncoupling protein is a membrane potential driven H+ translocator. EMBO Journal 1985, 4:3087-3092.
77. Krämer R., Palmieri F. Molecular aspects of isolated and reconstituted carrier proteins from animal mitochondria. Biochimica et Biophysica Acta 1989, 974:1-23.
78. Kunji E.R.S., Crichton P.G. Mitochondrial carriers function as monomers. Biochimica et Biophysica Acta 2010, 1797:817-831.
79. Kunji E.R.S., Robinson A.J. Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers. Current Opinion in Structural Biology 2010, 20:440-447.
80. LaNoue K., Mizani S.M., Klingenberg M. Electrical imbalance of adenine nucleotide transport across the mitochondrial membrane. Journal of Biological Chemistry 1978, 253:191-198.
81. Lesuisse E., Lyver E.R., Knight S.A.B., Dancis A. Role of YHM1, encoding a mitochondrial carrier protein, in iron distribution of yeast. Biochemical Journal 2004, 378:599-607.
82. Lin C.S., Hackenberg H., Klingenberg E.M. The uncoupling protein from brown adipose tissue mitochondria is a dimer. A hydrodynamic study. FEBS Letters 1980, 113:304-306.
83. Lindhurst M.J., Fiermonte G., Song S., Struys E., De Leonardis F., Schwartzberg P.L. Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:15927-15932.
84. Ma C., Remani S., Sun J., Kotaria R., Mayor J.A., Walters D.E., et al. Identification of the substrate binding sites within the yeast mitochondrial citrate transport protein. Journal of Biological Chemistry 2007, 282:17210-17220.
85. Marobbio C.M.T., Agrimi G., Lasorsa F.M., Palmieri F. Identification and functional reconstitution of yeast mitochondrial carrier for S-adenosylmethionine. EMBO Journal 2003, 22:5975-5982.
86. Marobbio C.M.T., Di Noia M.A., Palmieri F. Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: Bacterial expression, reconstitution and functional characterization. Biochemical Journal 2006, 393:441-446.
87. Marobbio C.M.T., Giannuzzi G., Paradies E., Pierri C.L., Palmieri F. α-Isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier. Journal of Biological Chemistry 2008, 283:28445-28553.
88. Marobbio C.M.T., Vozza A., Harding M., Bisaccia F., Palmieri F., Walker J.E. Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate. EMBO Journal 2002, 21:5653-5661.
89. Miniero D.V., Cappello A.R., Curcio R., Ludovico A., Daddabbo L., Stipani I. Functional and structural role of amino acid residues in the matrix α-helices, termini and cytosolic loops of the bovine mitochondrial oxoglutarate carrier. Biochimica et Biophysica Acta 2011, 1807:302-310.
90. Monné M., Miniero D.V., Daddabbo L., Robinson A.J., Kunji E.R.S., Palmieri F. Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site. Journal of Biological Chemistry 2012, 287:7925-7934.
91. Monné M., Miniero D.V., Iacobazzi V., Bisaccia F., Fiermonte G. The mitochondrial oxoglutarate carrier: From identification to mechanism. Journal of Bioenergetics and Biomembranes 2013, 45:1-13.
92. Monné M., Palmieri F., Kunji E.R.S. The substrate specificity of mitochondrial carriers: Mutagenesis revisited. Molecular Membrane Biology 2013, 30:149-159.
93. Nelson D.R., Felix C.M., Swanson J.M. Highly conserved charge-pair networks in the mitochondrial carrier family. Journal of Molecular Biology 1998, 277:285-308.
94. Palmieri F. Mitochondrial carrier proteins. FEBS Letters 1994, 346:48-54.
95. Palmieri F. The mitochondrial transporter family (SLC25): Physiological and pathological implications. Pflügers Archives 2004, 447:689-709.
96. Palmieri F. Diseases caused by defects of mitochondrial carriers: A review. Biochimica et Biophysica Acta 2008, 1777:564-578.
97. Palmieri F. The mitochondrial transporter family SLC25: Identification, properties and physiopathology. Molecular Aspects of Medicine 2013, 34:465-484.
98. Palmieri F., Agrimi G., Blanco E., Castegna A., Di Noia M.A., Iacobazzi V. Identification of mitochondrial carriers in Saccharomyces cerevisiae by transport assay of reconstituted recombinant proteins. Biochimica et Biophysica Acta 2006, 1757:1249-1262.
99. Palmieri L., Agrimi G., Runswick M.J., Fearnley I.M., Palmieri F., Walker J.E. Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarate. Journal of Biological Chemistry 2001, 276:1916-1922.
100. Palmieri L., Arrigoni R., Blanco E., Carrari F., Zanor M.I., Studart-Guimaraes C. Molecular identification of an Arabidopsis S-adenosylmethionine transporter. Analysis of organ distribution, bacterial expression, reconstitution into liposomes, and functional characterization. Plant Physiology 2006, 142:855-865.
101. Palmieri F., Bisaccia F., Capobianco L., Dolce V., Fiermonte G., Iacobazzi V., et al. Transmembrane topology, genes, and biogenesis of the mitochondrial phosphate and oxoglutarate carriers. Journal of Bioenergetics and Biomembranes 1993, 25:493-501.
102. Palmieri L., De Marco V., Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E. Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis. FEBS Letters 1997, 410:447-451.
103. Palmieri F., Indiveri C., Bisaccia F., Krämer R. Functional properties of purified and reconstituted mitochondrial metabolite carriers. Journal of Bioenergetics and Biomembranes 1993, 25:525-535.
104. Palmieri L., Lasorsa F.M., De Palma A., Palmieri F., Runswick M.J., Walker J.E. Identification of the yeast ACR1 gene product as a succinate-fumarate transporter essential for growth on ethanol or acetate. FEBS Letters 1997, 417:114-118.
105. Palmieri L., Lasorsa F.M., Iacobazzi V., Runswick M.J., Palmieri F., Walker J.E. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. FEBS Letters 1999, 462:472-476.
106. Palmieri L., Lasorsa F.M., Vozza A., Agrimi G., Fiermonte G., Runswick M.J. Identification and functions of new transporters in yeast mitochondria. Biochimica et Biophysica Acta 2000, 1459:363-369.
107. Palmieri L., Palmieri F., Runswick M.J., Walker J.E. Identification by bacterial expression and functional reconstitution of the yeast genomic sequence encoding the mitochondrial dicarboxylate carrier protein. FEBS Letters 1996, 399:299-302.
108. Palmieri L., Pardo B., Lasorsa F.M., del Arco A., Kobayashi K., Iijima M. Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria. EMBO Journal 2001, 20:5060-5069.
109. Palmieri L., Picault N., Arrigoni R., Besin E., Palmieri F., Hodges M. Molecular identification of three Arabidopsis thaliana mitochondrial dicarboxylate carrier isoforms: Organ distribution, bacterial expression, reconstitution into liposomes and functional characterization. Biochemical Journal 2008, 410:621-629.
110. Palmieri F., Pierri C.L. Mitochondrial metabolite transport. Essays in Biochemistry 2010, 47:37-52.
111. Palmieri F., Pierri C.L. Structure and function of mitochondrial carriers-Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Letters 2010, 584:1931-1939.
112. Palmieri F., Pierri C.L., De Grassi A., Nunes-Nesi A., Fernie A.R. Evolution, structure and function of mitochondrial carriers: A review with new insights. Plant Journal 2011, 66:161-181.
113. Palmieri F., Quagliariello E., Klingenberger M. Kinetics and specificity of the oxoglutarate carrier in rat-liver mitochondria. European Journal of Biochemistry 1972, 29:408-416.
114. Palmieri F., Rieder B., Ventrella A., Blanco E., Do P.T., Nunes-Nesi A. Molecular identification and functional characterization of Arabidopsis thaliana mitochondrial and chloroplastic NAD+ carrier proteins. Journal of Biological Chemistry 2009, 284:31249-31259.
115. Palmieri L., Rottensteiner H., Girzalsky W., Scarcia P., Palmieri F., Erdmann R. Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter. EMBO Journal 2001, 20:5049-5059.
116. Palmieri L., Runswick M.J., Fiermonte G., Walker J.E., Palmieri F. Yeast mitochondrial carriers: Bacterial expression, biochemical identification and metabolic significance. Journal of Bioenergetics and Biomembranes 2000, 32:67-77.
117. Palmieri F., Stipani I., Quagliariello E., Klingenberg M. Kinetic study of the tricarboxylate carrier in rat liver mitochondria. European Journal of Biochemistry 1972, 26:587-594.
118. Palmieri L., Vozza A., Agrimi G., De Marco V., Runswick M.J., Palmieri F., et al. Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate. Journal of Biological Chemistry 1999, 274:22184-22190.
119. Palmieri L., Vozza A., Hönlinger A., Dietmeier K., Palmisano A., Zara V., et al. The mitochondrial dicarboxylate carrier is essential for the growth of Saccharomyces cerevisiae on ethanol or acetate as the sole carbon source. Molecular Microbiology 1999, 31:569-577.
120. Palmisano A., Zara V., Hönlinger A., Vozza A., Dekker P.J.T., Pfanner N., et al. Targeting and assembly of the oxoglutarate carrier: General principles for biogenesis of carrier proteins of the mitochondrial inner membrane. Biochemical Journal 1998, 333:151-158.
121. Pebay-Peyroula E., Dahout-Gonzalez C., Kahn R., Trézéguet V., Lauquin G.J.-M., Brandolin G. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature 2003, 426:39-44.
122. Pfaff E., Klingenberg M. Adenine nucleotide translocation of mitochondria. 1. Specificity and control. European Journal of Biochemistry 1968, 6:66-79.
123. Pfaff E., Klingenberg M., Heldt H.W. Unspecific permeation and specific exchange of adenine nucleotides in liver mitochondria. Biochimica et Biophysica Acta 1965, 104:312-315.
124. Picault N., Hodges M., Palmieri L., Palmieri F. The growing family of mitochondrial carriers in Arabidopsis. Trends in Plant Science 2004, 9:138-146.
125. Picault N., Palmieri L., Pisano I., Hodges M., Palmieri F. Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria. Bacterial expression, reconstitution, functional characterization, and tissue distribution. Journal of Biological Chemistry 2002, 277:24204-24211.
126. Pierri C.L., Palmieri F., De Grassi A. Single-nucleotide evolution quantifies the importance of each site along the structure of mitochondrial carriers. Cellular and Molecular Life Sciences 2013, 71:349-364.
127. Poduri A., Heinzen E., Chitsazzadeh V., Lasorsa F., LaCoursiere C., Martin E., et al. SLC25A22 is a novel gene for migrating partial seizures in infancy. Annals of Neurology 2013, 74:873-882.
128. Przybyla-Zawislak B., Dennis R.A., Zakharkin S.O., McCammon M.T. Genes of succinyl-CoA ligase from Saccharomyces cerevisiae. European Journal of Biochemistry 1998, 258:736-743.
129. Riccio P., Aquila H., Klingenberg M. Purification of the carboxy-atractylate binding protein from mitochondria. FEBS Letters 1975, 56:133-138.
130. Robinson A.J., Kunji E.R.S. Mitochondrial carriers in the cytoplasmic state have a common substrate binding site. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:2617-2622.
131. Robinson A.J., Overy C., Kunji E.R.S. The mechanism of transport by mitochondrial carriers based on analysis of symmetry. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:17766-17771.
132. Runswick M.J., Powell S.J., Nyren P., Walker J.E. Sequence of the bovine mitochondrial phosphate carrier protein: Structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein. EMBO Journal 1987, 6:1367-1373.
133. Runswick M.J., Walker J.E., Bisaccia F., Iacobazzi V., Palmieri F. Sequence of the bovine 2-oxoglutarate/malate carrier protein: Structural relationship to other mitochondrial transport proteins. Biochemistry 1990, 29:11033-11040.
134. Ruprecht J.J., Hellawell A.M., Harding M., Crichton P.G., McCoy A.J., Kunji E.R.S. Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism. Proceedings of the National Academy of Sciences of the United States of America 2014, 111:E426-E434.
135. Saraste M., Walker J.E. Internal sequence repeats and the path of polypeptide in mitochondrial ADP/ATP translocase. FEBS Letters 1982, 144:250-254.
136. Schroers A., Burkovski A., Wohlrab H., Krämer R. The phosphate carrier from yeast mitochondria. Dimerization is a prerequisite for function. Journal of Biological Chemistry 1998, 273:14269-14676.
137. Sluse F.E., Duyckaerts C., Liebecq S., Sluse-Goffart M. Kinetic and binding properties of the oxoglutarate translocator of rat-heart mitochondria. European Journal of Biochemistry 1979, 100:3-17.
138. Sluse F.E., Evens A., Dierks T., Duyckaerts C., Sluse-Goffart C.M., Krämer R. Kinetic study of the aspartate/glutamate carrier in intact rat heart mitochondria and comparison with a reconstituted system. Biochimica et Biophysica Acta 1991, 1058:329-338.
139. Stappen R., Krämer R. Kinetic mechanism of phosphate/phosphate and phosphate/OH- antiports catalyzed by reconstituted phosphate carrier from beef heart mitochondria. Journal of Biological Chemistry 1994, 269:11240-11246.
140. Stepien G., Torroni A., Chung A.B., Hodge J.A., Wallace D.C. Differential expression of adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation. Journal of Biological Chemistry 1992, 267:14592-14597.
141. Stipani V., Cappello A.R., Daddabbo L., Natuzzi D., Miniero D.V., Stipani I., et al. The mitochondrial oxoglutarate carrier: Cysteine-scanning mutagenesis of transmembrane domain IV and sensitivity of Cys mutants to sulfhydryl reagents. Biochemistry 2001, 40:15805-15810.
142. Todisco S., Agrimi G., Castegna A., Palmieri F. Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae. Journal of Biological Chemistry 2006, 281:1524-1531.
143. Tonazzi A., Console L., Giangregorio N., Indiveri C., Palmieri F. Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups. Biochimica et Biophysica Acta 2012, 1817:697-704.
144. Traba J., Satrústegui J., del Arco A. Characterization of SCaMC-3-like/slc25a41, a novel calcium-independent mitochondrial ATP-Mg/Pi carrier. Biochemical Journal 2009, 418:125-133.
145. Villiers C., Michejda J.W., Block M., Lauquin G.J., Vignais P.V. The electrogenic nature of ADP/ATP transport in inside-out submitochondrial particles. Biochimica et Biophysica Acta 1979, 546:157-170.
146. Vozza A., Blanco E., Palmieri L., Palmieri F. Identification of the mitochondrial GTP/GDP transporter in Saccharomyces cerevisiae. Journal of Biological Chemistry 2004, 279:20850-20857.
147. Vozza A., Parisi G., De Leonardis F., Lasorsa F.M., Castegna A., Amorese D., et al. UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation. Proceedings of the National Academy of Sciences of the United States of America 2014, 111:960-965.
148. Wang Y., Tajkhorshid E. Electrostatic funneling of substrate in mitochondrial inner membrane carriers. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:9598-9603.
149. Watt I.N., Montgomery M.G., Runswick M.J., Leslie A.G.W., Walker J.E. Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:16823-16827.
150. Wibom R., Lasorsa F.M., Töhönen V., Barbaro M., Sterky F.H., Kucinski T. AGC1 deficiency associated with global cerebral hypomyelination. New England Journal of Medicine 2009, 361:489-495.
151. Wohlrab H., Annese V., Haefele A. Single replacement constructs of all hydroxyl, basic, and acidic amino acids identify new function and structure-sensitive regions of the mitochondrial phosphate transport protein. Biochemistry 2002, 41:3254-3261.
152. Zara V., Ferramosca A., Palmisano I., Palmieri F., Rassow J. Biogenesis of rat mitochondrial citrate carrier (CIC): The N-terminal presequence facilitates the solubility of the preprotein but does not act as a targeting signal. Journal of Molecular Biology 2003, 325:399-408.
153. Zara V., Ferramosca A., Robitaille-Foucher P., Palmieri F., Young J.C. Mitochondrial carrier protein biogenesis: Role of the chaperones Hsc70 and Hsp90. Biochemical Journal 2009, 419:369-375.
154. Zara V., Palmieri F., Mahlke K., Pfanner N. The cleavable presequence is not essential for import and assembly of the phosphate carrier of mammalian mitochondria but enhances the specificity and efficiency of import. Journal of Biological Chemistry 1992, 267:12077-12081.