Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism

FEBS Letters

Volumn 584, Issue 9, 2010, Pages 1931-1939

  Palmieri, Ferdinando ^a   Pierri, Ciro Leonardo ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Membrane protein; Mitochondrial carrier; Mitochondrial carrier disease; Mitochondrial carrier proline and glycine; Transport mechanism; Transporter structure

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ARGININE; ASPARTATE GLUTAMATE CARRIER ISOFORM 1; CARRIER PROTEIN; GLUTAMINE; GLYCINE; PROLINE; SLC25A38 PROTEIN; UNCLASSIFIED DRUG; MITOCHONDRIAL PROTEIN;

AGC1 DEFICIENCY; ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT; AUTOSOMAL RECESSIVE DISORDER; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; ENZYME SPECIFICITY; HUMAN; MEMBRANE TRANSPORT; MISSENSE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; SEQUENCE ALIGNMENT; SIDEROBLASTIC ANEMIA; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETICS; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; HUMANS; ION CHANNEL GATING; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77951892877     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.10.063     Document Type: Review

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