GABARBP down-regulates HIF-1α expression through the VEGFR-2 and PI3K/mTOR/4E-BP1 pathways

Cellular Signalling

Volumn 26, Issue 7, 2014, Pages 1506-1513

  Park, Sung Ho ^a   Kim, Boh Ram ^b   Lee, Jeong Heon ^c   Park, Sung Taek ^a   Lee, Seung Hoon ^d   Dong, Seung Myung ^b   Rho, Seung Bae ^b  

^a Hallym University   (South Korea)

^b National Cancer Center   (South Korea)

^c Chonbuk National University Medical School   (South Korea)

^d Yongin University   (South Korea)

Author keywords

Anti angiogenic activity; GABARBP; HIF 1 expression; Protein protein interaction; VEGF receptor 2

Indexed keywords

GAMMA AMINOBUTYRATE TYPE A RECEPTOR BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; S6 KINASE; TUBERIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; 4 AMINOBUTYRIC ACID A RECEPTOR; EIF4EBP1 PROTEIN, HUMAN; GABARAP PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TARGET OF RAPAMYCIN KINASE; VASCULOTROPIN A;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; MIGRATION INHIBITION; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UMBILICAL VEIN ENDOTHELIAL CELL; APOPTOSIS; BIOSYNTHESIS; CELL MOTION; CELL PROLIFERATION; CELL TRANSFORMATION; FEMALE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); OVARY TUMOR; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; VASCULARIZATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICROTUBULE-ASSOCIATED PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, GABA-A; TOR SERINE-THREONINE KINASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84898603127     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2014.03.017     Document Type: Article

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