Fast development of Pichia pastoris GS115 Mut+ cultures employing batch-to-batch control and hybrid semi-parametric modeling

Bioprocess and Biosystems Engineering

Volumn 37, Issue 4, 2014, Pages 629-639

  Ferreira, A R ^a   Dias, J M L ^a   Von Stosch, M ^a   Clemente, J ^b   Cunha, A E ^b   Oliveira, Rui ^a,b  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Batch to batch optimization; Fed batch fermentation optimization; Hybrid parametric non parametric modeling; Pichia pastoris; Single chain antibody fragment

Indexed keywords

ANTIBODIES; CHAINS; FEEDING; FERMENTATION; ITERATIVE METHODS; METHANOL; YEAST;

BATCH OPTIMIZATION; BIOMASS CONCENTRATIONS; CONTROL DEGREES OF FREEDOM; FED-BATCH FERMENTATION OPTIMIZATION; MODEL BASED OPTIMIZATION; PICHIA PASTORIS; SEMI-PARAMETRIC MODELING; SINGLE-CHAIN ANTIBODIES;

OPTIMIZATION;

GLYCEROL; METHANOL; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIBODY TITER; ARTICLE; BATCH TO BATCH CONTROL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE OPTIMIZATION; EXPLORATORY RESEARCH; FUNGAL BIOMASS; FUNGAL STRAIN; FUNGUS CULTURE; HYBRID SEMI PARAMETRIC MODELING; NONHUMAN; PH; PICHIA PASTORIS; PRIORITY JOURNAL; TEMPERATURE; BIOLOGICAL MODEL; BIOREACTOR; GENETICS; GROWTH, DEVELOPMENT AND AGING; MUTATION; PICHIA;

BIOREACTORS; MODELS, BIOLOGICAL; MUTATION; PICHIA;

EID: 84898546319     PISSN: 16157591     EISSN: 16157605     Source Type: Journal    
DOI: 10.1007/s00449-013-1029-9     Document Type: Article

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