Correlation of subcellular compartmentalization of HPMA copolymer-Mce6 conjugates with chemotherapeutic activity in human ovarian carcinoma cells

Pharmaceutical Research

Volumn 20, Issue 5, 2003, Pages 728-737

  Tijerina, Monica ^a   Kopečková, Pavla ^a,b   Kopeček, Jindrích ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

Author keywords

Mesochlorin e6 monoethylenediamine (Mce6); N (2 hydroxypropyl)methacrylamide (HPMA); Nuclear localization sequences (NLS); Photodynamic therapy (PDT)

Indexed keywords

ETHYLENEDIAMINE DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE; MESOCHLORIN E6 ETHYLENEDIAMINE; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL FRACTIONATION; CELLULAR DISTRIBUTION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; LOW TEMPERATURE; OVARY CARCINOMA; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL;

CELL LINE, TUMOR; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MESOPORPHYRINS; METHACRYLATES; PORPHYRINS; SUBCELLULAR FRACTIONS;

EID: 0242585001     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023425300829     Document Type: Article

References (31)

1. J. Moan and K. Berg. The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochem. Photobiol. 53:549-553 (1991).
2. Q. Peng, J. Moan, and J. M. Nesland. Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy. Ultrastruct. Pathol. 20:109-129 (1996).
3. Q. Peng, J. Moan, L. W. Ma, and J. M. Nesland. Uptake, localization, and photodynamic effect of meso-tetra(hydroxyphenyl)porphine and its corresponding chlorin in normal and tumor tissues of mice bearing mammary carcinoma. Cancer Res. 55:2620-2626 (1995).
4. Y. Matsumura and H. Maeda. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS. Cancer Res. 46:6387-6392 (1986).
5. H. F. Dvořák, J. A. Nagy, J. T. Dvořák, and A. M. Dvořák. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am. J. Pathol. 133:95-109 (1988).
6. J. W. Baish, P. A. Netti, and R. K. Jain. Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors. Microvasc. Res. 53:128-141 (1997).
7. 6) and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts. J. Control. Release 61:145-157 (1999).
8. J. Kopeček, P. Kopecková, T. Minko, and Z. Lu. HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action. Eur. J. Pharm. Biopharm. 50:61-81 (2000).
9. Z. R. Lu, P. Kopečkovǎ, and J. Kopeček. Polymerizable Fab′ antibody fragments for targeting of anticancer drugs. Nat. Biotechnol. 17:1101-1104 (1999).
10. 6 enhances its photosensitizing activity. J. Biol. Chem. 272:20328-20331 (1997).
11. 6 photodynamic activity in vitro with peptide-based intracellular vehicles. Bioconjug. Chem. 10:982-992 (1999).
12. N. L. Krinick, Y. Sun, D. Joyner, J. D. Spikes, R. C. Straight, and J. Kopeček. A polymeric drug delivery system for the simultaneous delivery of drugs activatable by enzymes and/or light. J. Biomater. Sci. Polym. Ed. 5:303-324 (1994).
13. R. Duncan and J. B. Lloyd. Pinocytosis in the rat visceral yolk sac. Effects of temperature, metabolic inhibitors and some other modifiers. Biochim. Biophys. Acta 544:647-655 (1978).
14. J. Kopeček and H. Bažilová. Poly[N-(2-hydroxypropyl)methacrylamide]. 1. Radical polymerization and copolymerization. Europ. Polym. J. 9:7-14 (1973).
15. P. Rejmanová, J. Labský, and J. Kopeček. Aminolyses of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids. Makromol. Chem. 178:2159-2168 (1977).
16. H. R. Yen, J. Kopeček, and J. D. Andrade. Optically controlled ligand delivery. 1. Synthesis of water-soluble copolymers containing photocleavable bonds. Makromol. Chem. 190:69-82 (1989)
17. K. Ulbrich, C. Koňák, Z. Tuzar, and J. Kopeček. Solution properties of drug carriers based on poly[N-(2-hydroxypropyl)methacrylamide] containing biodegradable bonds. Makromol. Chem. 188:1261-1272 (1987).
18. 6 - N-(2-hydroxypropyl)methacrylamide copolymer conjugate. J. Photochem. Photobiol. A: Chem. 70:163-170 (1993).
19. D. Kessel, Y. Luo, P. Mathieu, and J. J. Reiners Jr. Determinants of the apoptotic response to lysosomal photodamage. Photochem. Photobiol. 71:196-200 (2000).
20. 6 triacetoxymethyl ester (CAME). Photochem. Photobiol. 71:94-96 (2000).
21. K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young. Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model. Photochem. Photobiol. 65:410-415 (1997).
22. W. N. Leung, X. Sun, N. K. Mak, and C. M. Yow. Photodynamic effects of mTHPC on human colon adenocarcinoma cells: photocytotoxicity, subcellular localization and apoptosis. Photochem. Photobiol. 75:406-411 (2002).
23. K. Berg. and J. Moan. Lysosomes as photochemical targets. Int. J. Cancer 59:814-822 (1994).
24. J. Moan, K. Berg, H. Anholt, and K. Madslien. Sulfonated aluminium phthalocyanines as sensitizers for photochemotherapy. Effects of small light doses on localization, dye fluorescence and photosensitivity in V79 cells. Int. J. Cancer 58:865-870 (1994).
25. P. D. Wilson, R. A. Firestone, and J. Lenard. The role of lysosomal enzymes in killing of mammalian cells by the lysosomotropic detergent N-dodecylimidazole. J. Cell Biol. 104:1223-1229 (1987).
26. T. T. Lah, M. Kokalj-Kunovar, B. Strukelj, J. Pungercar, D. Barlic-Maganja, M. Drobnic-Kosorok, L. Kastelic, J. Babnik, R. Golouh, and V. Turk. Stefins and lysosomal cathepsins B, L and D in human breast carcinoma. Int. J. Cancer 50:36-44 (1992).
27. A. A. Rosenkranz, D. A. Jans, and A. S. Sobolev. Targeted intracellular delivery of photosensitizers to enhance photodynamic efficiency. Immunol. Cell Biol. 78:452-464 (2000).
28. D. A. Jans and S. Hubner. Regulation of protein transport to the nucleus: central role of phosphorylation. Physiol. Rev. 76:651-685 (1996).
29. 6) conjugates. Photochem. Photobiol. 65:723-729 (1997).
30. D. Kessel, Y. Luo, Y. Deng, and C. K. Chang. The role of subcellular localization in initiation of apoptosis by photodynamic therapy. Photochem. Photobiol. 65:422-426 (1997).
31. W. P. Thorpe, M. Toner, R. M. Ezzell, R. G. Tompkins, and M. L. Yarmush. Dynamics of photoinduced cell plasma membrane injury. Biophys. J. 68:2198-2206 (1995).