Calotropin: A cardenolide from calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1α in colon cancer cells

ChemBioChem

Volumn 15, Issue 6, 2014, Pages 872-878

  Park, Hyun Young ^a   Toume, Kazufumi ^a   Arai, Midori A ^a   Sadhu, Samir K ^b   Ahmed, Firoj ^c   Ishibashi, Masami ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KHULNA UNIVERSITY   (Bangladesh)

^c UNIVERSITY OF DHAKA   (Bangladesh)

Author keywords

Calotropis gigantea; cardenolides; casein kinase 1alpha; natural products; signal transduction; Wnt signaling

Indexed keywords

2'' OXOVORUSCHARIN; ANALGESIC AGENT; ASCLEPIN; BETA CATENIN; CALOTROPIN; CALOTROPIS GIGANTEA EXTRACT; CARDENOLIDE DERIVATIVE; CASEIN KINASE IALPHA; MESSENGER RNA; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG; USCHARIDIN; USCHARIN; VORUSCHARIN; CARDENOLIDE; WNT PROTEIN;

ANALGESIC ACTIVITY; ARTICLE; CALOTROPIS GIGANTEA; CANCER CELL; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; IC 50; NONHUMAN; PLANT EXUDATE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; WNT SIGNALING PATHWAY; ANTAGONISTS AND INHIBITORS; CALOTROPIS; CHEMISTRY; COLON TUMOR; DRUG EFFECTS; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BETA CATENIN; CALOTROPIS; CARDENOLIDES; CASEIN KINASE IALPHA; CELL LINE, TUMOR; COLONIC NEOPLASMS; HUMANS; PHOSPHORYLATION; RNA, MESSENGER; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84898438232     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300786     Document Type: Article

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