Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer

Oncology Letters

Volumn 5, Issue 5, 2013, Pages 1719-1723

  Mo, Min Li ^a   Li, Meng Ru ^b   Chen, Zhao ^a   Liu, Xing Wei ^c   Sheng, Qing ^b   Zhou, Hai Meng ^a  

^a TSINGHUA UNIVERSITY   (China)

^b ZHEJIANG SCI TECH UNIVERSITY   (China)

^c Beijing ACCB Biotech Ltd   (China)

Author keywords

Gastric cancer; Palmitoylation; Palmitoyltransferase; Porcupine; Wnt

Indexed keywords

BETA CATENIN; CASPASE 3; CASPASE 7; LUCIFERASE; TRANSFERASE; UNCLASSIFIED DRUG; WNT PALMITOYLTRANSFERASE PORCUPINE; WNT PROTEIN;

ARTICLE; CANCER GROWTH; CELL CULTURE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE C MYC; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STOMACH CANCER; WESTERN BLOTTING;

EID: 84875726057     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1256     Document Type: Article

References (25)

1. Polakis P: Wnt signaling and cancer. Genes Dev 14: 1837-1851, 2000.
2. Klaus A and Birchmeier W: Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8: 387-398, 2008.
3. Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell 149: 1192-1205, 2012.
4. Kadowaki T, Wilder E, Klingensmith J, Zachary K and PerrimonN: The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev 10: 3116-3128, 1996.
5. Hofmann K: A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem Sci 25: 111-112, 2000.
6. Willert K, Brown JD, Danenberg E, et al: Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423: 448-452, 2003.
7. Nusse R: Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development 130: 5297-5305, 2003.
8. Galli LM, Barnes TL, Secrest SS, Kadowaki T and Burrus LW: Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube. Development 134: 3339-3348, 2007.
9. Coudreuse D and Korswagen HC: The making of Wnt: new insights into Wnt maturation, sorting and secretion. Development 134: 3-12, 2007.
10. Chen B, Dodge ME, Tang W, et al: Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 5: 100-107, 2009.
11. Dodge ME, Moon J, Tuladhar R, et al: Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem 287: 23246-23254, 2012.
12. Takahashi-Yanaga F and Kahn M: Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res 16: 3153-3162, 2010.
13. Chen W, Chen M and Barak LS: Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach. Am J Physiol Gastrointest Liver Physiol 299: G293-G300, 2010.
14. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
15. Yang L: Incidence and mortality of gastric cancer in China. World J Gastroenterol 12: 17-20, 2006.
16. Du R, Xia L, Sun S, et al: URG11 promotes gastric cancer growth and invasion by activation of beta-catenin signalling pathway. JCell Mol Med 14: 621-635, 2010.
17. Ganesan K, Ivanova T, Wu Y, et al: Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene. Cancer Res 68: 4277-4286, 2008.
18. Zhang H and Xue Y: Wnt pathway is involved in advanced gastric carcinoma. Hepatogastroenterology 55: 1126-1130, 2008.
19. Mo ML, Chen Z, Li J, et al: Use of serum circulating CCNB2 in cancer surveillance. Int J Biol Markers 25: 236-242, 2010.
20. Chen Z, Fan JQ, Li J, et al: Promoter hypermethylation correlates with the Hsulf-1 silencing in human breast and gastric cancer. Int J Cancer 124: 739-744, 2009.
21. Li J, Mo ML, Chen Z, et al: HSulf-1 inhibits cell proliferation and invasion in human gastric cancer. Cancer Sci 102: 1815-1821, 2011.
22. Chen Z, Li J, Li QS, et al: Suppression of PPN/MG61 attenuates Wnt/beta-catenin signaling pathway and induces apoptosis in human lung cancer. Oncogene 27: 3483-3488, 2008.
23. Zhang L, Hou Y, Ashktorab H, et al: The impact of C-MYC gene expression on gastric cancer cell. Mol Cell Biochem 344: 125-135, 2010.
24. Wolfer A and Ramaswamy S: MYC and metastasis. Cancer Res 71: 2034-2037, 2011.
25. Tamm I, Wang Y, Sausville E, et al: IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res 58: 5315-5320, 1998.