The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain

Development

Volumn 127, Issue 24, 2000, Pages 5285-5295

  Ellies, D L ^a   Church, V ^a   Francis West, P ^a   Lumsden, A ^a  

^a STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Chick; Neural crest cell; Programmed cell death; Wnt

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; TRANSCRIPTION FACTOR; WNT PROTEIN;

APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CELL LOSS; CONTROLLED STUDY; EMBRYO; FOWL; MODULATION; MORPHOGENESIS; NEURAL CREST CELL; NEUROMERE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RHOMBENCEPHALON; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BONE MORPHOGENETIC PROTEINS; CHICK EMBRYO; DNA PRIMERS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; MODELS, NEUROLOGICAL; NEURAL CREST; PROTEINS; PROTO-ONCOGENE PROTEINS; RHOMBENCEPHALON; WNT PROTEINS; WNT1 PROTEIN; ZEBRAFISH PROTEINS;

AVES; GALLIFORMES;

EID: 0034518395     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (86)

1. Antisense attenuation of Wntl and Wnt3a expression embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis
2. Wnt signalling in Xenpus embryos inhibits Bmp4 expression and activates neural development
3. Stress signals for apoptosis: Ceramide and c-Jun kinase
4. Rhombomeric origin and rostracaudal reassortment of neural crest cells revealed by intravital microscopy
5. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signalling
6. A beta-catenin/XTCF3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
7. Pangolin encodes a Lef1 homologue that acts downstrean of Armadillo to transduce the Wingless signal Drosophila
8. Antagonistic effects of FGF4 on BMP induction of apoptosis and chondrogenesis in the chick limb bud
9. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium
10. TCF4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs
11. The regeneration of the cephalic neural crest, a problem revisited: The regenerating cells originate from the contralateral or from the anterior and posterior neural fold
12. Control of NC cell fate by the Wnt signalling pathway
13. Regulation of LEF1/TCF transcription factors by Wnt and other signals
14. A paraxial exclusion zone creates patterned cranial neural crest cell outgrowth adjacent to rhombomeres 2 and 5
15. Ectopic expression of Msx-2 in posterior limb bud mesoderm impairs limb morphogenesis while inducing BMP-4 expression, inhibiting cell proliferation, and promoting apoptosis
16. Purification amd molecular cloning of a secreted, Frizzled-related antagonist of Wnt action
17. Disruption of Msx-1 and Msx-2 reveals roles for these genes in craniofacial, eye, and axial development
18. Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb
19. Segmentation in the chick embryo hidbrain is defined by cell linage restrictions
20. Morphological diversity of the avian foot is related with the pattern of msx gene expression in the developing autopod
21. Role of TGFβs and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod
22. The signalling molecule BMP4 mediates apoptosis in the rhombecephalic NC
23. Even-numbered rhombomeres control the apoptotic elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain
24. NC apoptosis and the establishment of craniofacial pattern: An honorable death
25. In situ detection of fragmented DNA (TUNEL) fails to discriminate among apoptosis, necrosis, and autolytic death: A cautionary note
26. The Hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in the Gli-3-deficient mice
27. A series of normal stages in the development of the chick embryo
28. Wingless signaling generates pattern through two distinct mechanism
29. Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members
30. Wnt expression patterns in chick embryo nervous system
31. Cwnt-8C: A novel Wnt gene with a potential role in primative streak formation and hindbrain organization
32. Wnt signaling required for expansion of neural crest and CNS progenitors
33. Programmed cell death in animal development
34. Cell death in cranial neural crest development
35. Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice
36. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud
37. Rhombencephalic NC segmentation is preserved throughout craniofacial ontogeny
38. Two members of the TCF family implicated in Wnt/beta-catenin signalling during embryogenesis in the implicated in the mouse Mol.
39. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
40. Neural crest cell dynamics revealed by time-lapse video microscopy of whole embryo chick explant cultures
41. In ovo time-lapse analysis of chick hindbrain nueral crest cell migration shows cell interactions during migration to the branchial arches
42. Neural crest induction in Xenopus: Evidence for a two-signal model
43. Cloning and expression of the Wnt antagonists Sfrp2 and FrzB during chick development
44. SHH-N upregulates Sdrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm
45. Development expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family
46. SFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney
47. Frzb-1 is a secreted antagonist of Wnt signalling expressed in the spemann organiser
48. Dishevelled proteins lead to two signaling pathways: Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells
49. The cellular basis of segmentation in the developing hindbrain
50. Cell lineage restrictions in the chick embryo hindbrain
51. Segmental origin and migration of NC cells in the hindbrain region of the chick embryo
52. Positional apoptosis during vertebrate CNS developmental in the absence of endogenous retinoids
53. A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth
54. Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway
55. The Wnt1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
56. SARPs: A family of secreted apoptosis related proteins
57. Bone morphogenetic proteins regulate interdigital cell death in the avian enbryo
58. WNTs modulate cell fate and behavior during development
59. Manipulating gene expression with replication-competent retroviruses
60. Relationship between spatially restricted Krox-20 gene expression in branchial neural crest and segmentation in the chick embryo hindbrain
61. Wnt genes and vertebrate development
62. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors
63. Inhibition of chondrogenesis by Wnt 1 gene expression in vivo and in vitro
64. Regulation of dorsal fate in the neuraxis by Wnt1 and Wnt3a
65. Sizzled: A secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos
66. Segmental migration of the hindbrain neural crest does not arise from its segmental generation
67. Cell Death in the CNS of the Wnt1 mutant mouse
68. Characterisation of novel secreted and membrane proteins isolated by the signal sequence trap method
69. Frizzled signaling and the developmental control of cell polarity
70. Adenovirus-mediated ectopic expression of Msx2 in even-numbered rhombomeres induces apoptotic elimination of cranial neural crest cells in ovo
71. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase
72. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
73. Frzb-1, an antagonist of Wnt 1 and Wnt-8, does not block signaling by Wnts-3A,-5A, or -11
74. Is programmed cell death required for neural tube closure
75. Dual functions of wingless in the Drosophilla leg imaginal disc
76. Perinatal lethality and multiple craniofacial malformation in MSX2 transgenetic mice
77. Mechanisms of Wnt signaling in development
78. DDC-4, an apoptosis associated gene, is a secreted frizzled relative
79. Functional and biochemical interactions of Wnts with DrzA, a secreted Wnt antagonist
80. BMP-2/-4 mediate programmed cell death in chicken limb byds
81. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
82. Evidence that absence of Wnt3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse
83. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
84. Requirement for BMP signalling in interdigital apoptosis and scale formation
85. Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumours