Midazolam induces cellular apoptosis in human cancer cells and inhibits tumor growth in xenograft mice

Molecules and Cells

Volumn 36, Issue 3, 2013, Pages 219-226

  Mishra, Siddhartha Kumar ^a,f   Kang, Ju Hee ^b,c   Lee, Chang Woo ^d   Oh, Seung Hyun ^a   Ryu, Jun Sun ^b   Bae, Yun Soo ^e   Kim, Hwan Mook ^a  

^a Gachon University College of Medicine   (South Korea)

^b National Cancer Center   (South Korea)

^c Chung Ang University   (South Korea)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^e Ewha Womans University   (South Korea)

^f DR H S GOUR UNIVERSITY   (India)

Author keywords

Anesthesia; Anticancer; Apoptosis induction; Midazolam; ROS scavenging

Indexed keywords

CASPASE 3; CASPASE 9; MIDAZOLAM; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BCL XL; PROTEIN BID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; X LINKED INHIBITOR OF APOPTOSIS; ANTINEOPLASTIC AGENT; CENTRAL DEPRESSANT AGENT; CYBB PROTEIN, HUMAN; MEMBRANE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL PROLIFERATION; COLON CANCER; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; DRUG SCREENING; GENETICS; HT 29 CELL LINE; K562 CELL LINE; METABOLISM; NEOPLASM; PATHOLOGY; CELL STRAIN HT29; CELL STRAIN K 562; DRUG EFFECT;

MUS;

ADJUVANTS, ANESTHESIA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL PROLIFERATION; FEMALE; HT29 CELLS; HUMANS; K562 CELLS; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MIDAZOLAM; NADPH OXIDASE; NEOPLASMS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898269417     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-013-0050-9     Document Type: Article

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