The Ca2+ channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells

Apoptosis

Volumn 15, Issue 5, 2010, Pages 597-607

  Conrad, David M ^a   Furlong, Suzanne J ^a   Doucette, Carolyn D ^a   West, Kenneth A ^a   Hoskin, David W ^a,b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Apoptosis; Ca2+ channel; Caspase 10; Flunarizine; T leukemia cell

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE 10; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLUNARIZINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CELL MEMBRANE PERMEABILITY; CELL PERMEABILIZATION; COLON CANCER; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; T CELL LEUKEMIA;

APOPTOSIS; CALCIUM CHANNEL BLOCKERS; CASPASE 10; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLUNARIZINE; HUMANS; JURKAT CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 77951667716     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0454-3     Document Type: Article

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