Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways

Acta Biomaterialia

Volumn 8, Issue 6, 2012, Pages 2056-2067

  Cimini, Annamaria ^a,b   Dangelo, Barbara ^a   Das, Soumen ^c   Gentile, Roberta ^a   Benedetti, Elisabetta ^a   Singh, Virendra ^c   Monaco, Antonina Maria ^a   Santucci, Sandro ^a   Seal, Sudipta ^c  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b Temple University   (United States)

^c University of Central Florida   (United States)

Author keywords

Cerium oxide nanoparticle; Nanoparticles; Neurodegeneration; Neurotrophins; Targeted therapy

Indexed keywords

AGGREGATES; ANTIBODIES; ANTIOXIDANTS; CERIUM OXIDE; NEURODEGENERATIVE DISEASES; NEURONS; OXIDES;

ALZHEIMER; BRAIN-DERIVED NEUROTROPHIC FACTORS; CERIUM OXIDE NANOPARTICLE; NEURODEGENERATION; NEURONAL SURVIVAL; NEUROTROPHINS; PEGYLATED; POTENT ANTIOXIDANTS; SIGNALLING PATHWAYS; TARGETED THERAPY;

NANOPARTICLES;

AMYLOID BETA PROTEIN; ANTIBODY CONJUGATE; BETA TUBULIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CERIUM OXIDE NANOPARTICLE; MACROGOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; NANOPARTICLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BRAIN REGION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; NERVE DEGENERATION; NEUROMODULATION; NEUROPROTECTION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; SIGNAL TRANSDUCTION;

EID: 84863417805     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.01.035     Document Type: Article

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