Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy

ACS Nano

Volumn 5, Issue 11, 2011, Pages 8591-8599

  Choi, Ki Young ^a,b   Yoon, Hong Yeol ^b,c   Kim, Jong Ho ^d   Bae, Sang Mun ^d   Park, Rang Woon ^d   Kang, Young Mo ^d   Kim, In San ^d   Kwon, Ick Chan ^b   Choi, Kuiwon ^b   Jeong, Seo Young ^a   Kim, Kwangmeyung ^b   Park, Jae Hyung ^c  

^a Kyung Hee University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Kyungpook National University School of Medicine   (South Korea)

Author keywords

camptothecin; drug release; Hyal 1; hyaluronic acid; nanoparticle; tumor targeting

Indexed keywords

CAMPTOTHECINS; DRUG RELEASE; HYAL-1; HYALURONIC ACIDS; TUMOR TARGETING;

BINDING SITES; BODY FLUIDS; CELL CULTURE; CYTOTOXICITY; DRUG PRODUCTS; DRUG THERAPY; ETHYLENE; FIBROBLASTS; GLYCOLS; MAMMALS; MOLECULAR BIOLOGY; NANOPARTICLES; ONCOLOGY; ORGANIC ACIDS; POLYETHYLENE GLYCOLS; TUMORS;

DISEASES;

ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DOXORUBICIN; DRUG CARRIER; HYALURONIC ACID; MACROGOL DERIVATIVE; NANOPARTICLE;

ANIMAL; ARTICLE; CELL STRAIN 3T3; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HUMAN; METABOLISM; MOUSE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; CAMPTOTHECIN; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; HUMANS; HYALURONIC ACID; MICE; NANOPARTICLES; NIH 3T3 CELLS; POLYETHYLENE GLYCOLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 81855226471     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn202070n     Document Type: Article

References (40)

1. Duncan, R. The Dawning Era of Polymer Therapeutics Nat. Rev. Drug Discovery 2003, 2, 347-360 (Pubitemid 37361705)
2. Ferrari, M. Cancer Nanotechnology: Opportunities and Challenges Nat. Rev. Cancer 2005, 5, 161-171 (Pubitemid 40314948)
3. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an Emerging Platform for Cancer Therapy Nat. Nanotechnol. 2007, 2, 751-760 (Pubitemid 350223348)
4. Farokhzad, O. C.; Langer, R. Nanomedicine: Developing Smarter Therapeutic and Diagnostic Modalities Adv. Drug Delivery Rev. 2006, 58, 1456-1459 (Pubitemid 44820502)
5. Kim, K.; Kim, J. H.; Park, H.; Kim, Y. S.; Park, K.; Nam, H.; Lee, S.; Park, J. H.; Park, R. W.; Kim, I. S. et al. Tumor-Homing Multifunctional Nanoparticles for Cancer Theragnosis: Simultaneous Diagnosis, Drug Delivery, and Therapeutic Monitoring J. Controlled Release 2010, 146, 219-227
6. Kim, J. H.; Kim, Y. S.; Park, K.; Lee, S.; Nam, H. Y.; Min, K. H.; Jo, H. G.; Park, J. H.; Choi, K.; Jeong, S. Y. et al. Antitumor Efficacy of Cisplatin-Loaded Glycol Chitosan Nanoparticles in Tumor-Bearing Mice J. Controlled Release 2008, 127, 41-49
7. Farokhzad, O. C.; Langer, R. Impact of Nanotechnology on Drug Delivery ACS Nano 2009, 3, 16-20
8. Wang, X.; Li, J.; Wang, Y.; Cho, K. J.; Kim, G.; Gjyrezi, A.; Koenig, L.; Giannakakou, P.; Shin, H. J.; Tighiouart, M. et al. Hft-T, A Targeting Nanoparticle Enhances Specific Delivery of Paclitaxel to Folate Receptor-Positive Tumors ACS Nano 2009, 3, 3165-3174
9. Choi, K. Y.; Chung, H.; Min, K. H.; Yoon, H. Y.; Kim, K.; Park, J. H.; Kwon, I. C.; Jeong, S. Y. Self-Assembled Hyaluronic Acid Nanoparticles for Active Tumor Targeting Biomaterials 2010, 31, 106-114
10. Bae, Y.; Fukushima, S.; Harada, A.; Kataoka, K. Design of Environment-Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles That Are Responsive to Intracellular Ph Change 13 Angew. Chem., Int. Ed. 2003, 42, 4640-4643 (Pubitemid 37271305)
11. Ko, J.; Park, K.; Kim, Y.-S.; Kim, M. S.; Han, J. K.; Kim, K.; Park, R.-W.; Kim, I.-S.; Song, H. K.; Lee, D. S. et al. Tumoral Acidic Extracellular pH Targeting of pH-Responsive Mpeg-Poly([Beta]-Amino Ester) Block Copolymer Micelles for Cancer Therapy J. Controlled Release 2007, 123, 109-115 (Pubitemid 47562136)
12. Lee, E. S.; Gao, Z.; Bae, Y. H. Recent Progress in Tumor pH Targeting Nanotechnology J. Controlled Release 2008, 132, 164-170
13. Lee, Y.; Fukushima, S.; Bae, Y.; Hiki, S.; Ishii, T.; Kataoka, K. A Protein Nanocarrier from Charge-Conversion Polymer in Response to Endosomal pH J. Am. Chem. Soc. 2007, 129, 5362-5363 (Pubitemid 46697615)
14. Lee, S. M.; Ahn, R. W.; Chen, F.; Fought, A. J.; O'Halloran, T. V.; Cryns, V. L.; Nguyen, S. T. Biological Evaluation of pH-Responsive Polymer-Caged Nanobins for Breast Cancer Therapy ACS Nano 2010, 4, 4971-4978
15. Koo, A. N.; Lee, H. J.; Kim, S. E.; Chang, J. H.; Park, C.; Kim, C.; Park, J. H.; Lee, S. C. Disulfide-Cross-Linked Peg-Poly(Amino Acid)s Copolymer Micelles for Glutathione-Mediated Intracellular Drug Delivery Chem. Commun. 2008, 6570-6572
16. Miyata, K.; Kakizawa, Y.; Nishiyama, N.; Harada, A.; Yamasaki, Y.; Koyama, H.; Kataoka, K. Block Catiomer Polyplexes with Regulated Densities of Charge and Disulfide Cross-Linking Directed to Enhance Gene Expression J. Am. Chem. Soc. 2004, 126, 2355-2361 (Pubitemid 38295715)
17. Haba, K.; Popkov, M.; Shamis, M.; Lerner, R. A.; C., F. B., III; Shabat, D. Single-Triggered Trimeric Prodrugs 13 Angew. Chem., Int. Ed. 2005, 44, 716-720
18. Biswas, A.; Joo, K. I.; Liu, J.; Zhao, M.; Fan, G.; Wang, P.; Gu, Z.; Tang, Y. Endoprotease-Mediated Intracellular Protein Delivery Using Nanocapsules ACS Nano 2011, 5, 1385-1394
19. Lapcik, L. J.; Lapcik, L.; De Smedt, S.; Demeester, J.; Chabrecek, P. Hyaluronan: Preparation, Structure, Properties, and Applications Chem. Rev. 1998, 98, 2663-2684
20. Toole, B. P. Hyaluronan: From Extracellular Glue to Pericellular Cue Nat. Rev. Cancer 2004, 4, 528-539 (Pubitemid 38868622)
21. Eliaz, R. E.; Szoka, F. C., Jr. Liposome-Encapsulated Doxorubicin Targeted to Cd44: A Strategy to Kill Cd44-Overexpressing Tumor Cells Cancer Res. 2001, 61, 2592-2601 (Pubitemid 32685844)
22. Platt, V. M.; Szoka, F. C., Jr. Anticancer Therapeutics: Targeting Macromolecules and Nanocarriers to Hyaluronan or Cd44, a Hyaluronan Receptor Mol. Pharm. 2008, 5, 474-486
23. Auzenne, E.; Ghosh, S. C.; Khodadadian, M.; Rivera, B.; Farquhar, D.; Price, R. E.; Ravoori, M.; Kundra, V.; Freedman, R. S.; Klostergaard, J. Hyaluronic Acid-Paclitaxel: Antitumor Efficacy against Cd44(+) Human Ovarian Carcinoma Xenografts Neoplasia 2007, 9, 479-486 (Pubitemid 46983450)
24. Stern, R.; Jedrzejas, M. J. Hyaluronidases: Their Genomics, Structures, and Mechanisms of Action Chem. Rev. 2006, 106, 818-839
25. Lokeshwar, V. B.; Lokeshwar, B. L.; Pham, H. T.; Block, N. L. Association of Elevated Levels of Hyaluronidase, a Matrix-Degrading Enzyme, with Prostate Cancer Progression Cancer Res. 1996, 56, 651-657 (Pubitemid 26043668)
26. Lokeshwar, V. B.; Cerwinka, W. H.; Isoyama, T.; Lokeshwar, B. L. Hyal1 Hyaluronidase in Prostate Cancer: A Tumor Promoter and Suppressor Cancer Res. 2005, 65, 7782-7789 (Pubitemid 41297253)
27. Chao, K. L.; Muthukumar, L.; Herzberg, O. Structure of Human Hyaluronidase-1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis Biochemistry 2007, 46, 6911-6920 (Pubitemid 46906420)
28. Pham, H. T.; Block, N. L.; Lokeshwar, V. B. Tumor-Derived Hyaluronidase: A Diagnostic Urine Marker for High-Grade Bladder Cancer Cancer Res. 1997, 57, 778-783 (Pubitemid 27085666)
29. Franzmann, E. J.; Schroeder, G. L.; Goodwin, W. J.; Weed, D. T.; Fisher, P.; Lokeshwar, V. B. Expression of Tumor Markers Hyaluronic Acid and Hyaluronidase (Hyal1) in Head and Neck Tumors Int. J. Cancer 2003, 106, 438-445 (Pubitemid 36870409)
30. Liu, D.; Pearlman, E.; Diaconu, E.; Guo, K.; Mori, H.; Haqqi, T.; Markowitz, S.; Willson, J.; Sy, M. S. Expression of Hyaluronidase by Tumor Cells Induces Angiogenesis in Vivo Proc. Natl. Acad. Sci. U. S. A. 1996, 93, 7832-7837 (Pubitemid 26277124)
31. Delpech, B.; Laquerriere, A.; Maingonnat, C.; Bertrand, P.; Freger, P. Hyaluronidase Is More Elevated in Human Brain Metastases Than in Primary Brain Tumours Anticancer Res. 2002, 22, 2423-2427 (Pubitemid 34857077)
32. Bertrand, P.; Girard, N.; Duval, C.; d'Anjou, J. L.; Chauzy, C.; Ménard, J.-F. I.; Delpech, B. Increased Hyaluronidase Levels in Breast Tumor Metastases Int. J. Cancer 1997, 73, 327-331 (Pubitemid 27508893)
33. + Exchanger (Nhe1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion J. Biol. Chem. 2004, 279, 26991-27007 (Pubitemid 38812535)
34. Stern, R. Hyaluronidases in Cancer Biology Semin. Cancer Biol. 2008, 18, 275-280
35. Kumar, S.; West, D. C.; Ponting, J. M.; Gattamaneni, H. R. Sera of Children with Renal Tumours Contain Low-Molecular-Mass Hyaluronic Acid Int. J. Cancer 1989, 44, 445-448 (Pubitemid 19229301)
36. Itano, N. Simple Primary Structure, Complex Turnover Regulation and Multiple Roles of Hyaluronan J. Biochem. 2008, 144, 131-137
37. Coradini, D.; Perbellini, A. Hyaluronan: A Suitable Carrier for an Histone Deacetylase Inhibitor in the Treatment of Human Solid Tumors Cancer Ther. 2004, 2, 201-216
38. Choi, K. Y.; Min, K. H.; Na, J. H.; Choi, K.; Kim, K.; Park, J. H.; Kwon, I. C.; Jeong, S. Y. Self-Assembled Hyaluronic Acid Nanoparticles as a Potential Drug Carrier for Cancer Therapy: Synthesis, Characterization, and in Vivo Biodistribution J. Mater. Chem. 2009, 19, 4102-4107
39. Choi, K. Y.; Min, K. H.; Yoon, H. Y.; Kim, K.; Park, J. H.; Kwon, I. C.; Choi, K.; Jeong, S. Y. Pegylation of Hyaluronic Acid Nanoparticles Improves Tumor Targetability in Vivo Biomaterials 2011, 32, 1880-1889
40. Kwon, G. S.; Naito, M.; Yokoyama, M.; Okano, T.; Sakurai, Y.; Kataoka, K. Physical Entrapment of Adriamycin in Ab Block Copolymer Micelles Pharm. Res. 1995, 12, 192-195