Synergistic induction of apoptosis by methylseleninic acid and cisplatin, the role of ROS-ERK/AKT-p53 pathway

Molecular Pharmaceutics

Volumn 11, Issue 4, 2014, Pages 1282-1293

  Zhang, Yibo ^a   Zheng, Shanyuan ^b   Zheng, Jun Sheng ^c   Wong, Ka Hing ^d   Huang, Zhi ^a   Ngai, Sai Ming ^b   Zheng, Wenjie ^a   Wong, Yum Shing ^b   Chen, Tianfeng ^a  

^a JINAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c SUN YAT SEN UNIVERSITY   (China)

^d HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

apoptosis; cisplatin; methylseleninic acid; ROS; synergetic effects

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DEATH RECEPTOR; METHYLSELENINIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; METHYLSELENIC ACID; ORGANOSELENIUM DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER THERAPY; CELL ACTIVATION; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; DRUG SYNERGISM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; ORGANOSELENIUM COMPOUNDS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84897982383     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400749f     Document Type: Article

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