Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistance-associated protein 2 in rat liver

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 6, 2012, Pages 980-987

  Sekine, Shuichi ^a   Mitsuki, Kaori ^a   Ito, Kousei ^b   Kugioka, Satoe ^a   Horie, Toshiharu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Degradation; MRP2; Oxidative stress; Proteasome; SUMO; Ubiquitin

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BUTHIONINE SULFOXIMINE; GLUTATHIONE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; SUMO 1 PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT;

ANIMALS; BUTHIONINE SULFOXIMINE; CHOLESTASIS, INTRAHEPATIC; GLUTATHIONE; HEPATOCYTES; LEUPEPTINS; LIVER; LIVER FAILURE; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SUMO-1 PROTEIN; UBIQUITIN;

RATTUS;

EID: 84859094449     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.01.015     Document Type: Article

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