Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose

Biochemical Pharmacology

Volumn 77, Issue 10, 2009, Pages 1621-1628

  Ghanem, Carolina I ^a   Ruiz, María L ^b   Villanueva, Silvina S M ^b   Luquita, Marcelo ^b   Llesuy, Susana ^c   Catania, Viviana A ^b   Bengochea, Laura A ^a   Mottino, Aldo D ^b  

^a Instituto de Investigaciones Farmacologicas   (Argentina)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Acetaminophen; Enterohepatic recirculation; Liver toxicity; Mrp2; Mrp3

Indexed keywords

ACTIVATED CARBON; GLUTATHIONE; MARKER; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; PARACETAMOL; PARACETAMOL GLUCURONIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG MECHANISM; DRUG URINE LEVEL; ENTEROHEPATIC CIRCULATION; LIVER HOMOGENATE; LIVER INJURY; LIVER TOXICITY; MALE; METABOLITE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; CHARCOAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GLUTATHIONE; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MICROSCOPY, FLUORESCENCE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 64049104966     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.02.006     Document Type: Article

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