Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7

Toxicology and Applied Pharmacology

Volumn 277, Issue 1, 2014, Pages 86-94

  Ma, Hai Ying ^a   Sun, Dong Xue ^b   Cao, Yun Feng ^c,d   Ai, Chun Zhi ^d   Qu, Yan Qing ⁱ   Hu, Cui Min ^d,f   Jiang, Changtao ^e   Dong, Pei Pei ^g   Sun, Xiao Yu ^d   Hong, Mo ^d   Tanaka, Naoki ^e   Gonzalez, Frank J ^e   Ma, Xiao Chi ^c,d,g,h   Fang, Zhong Ze ^c,d,e  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c JINZHOU MEDICAL UNIVERSITY   (China)

^d DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^e YANTAISHAN HOSPITAL   (China)

^f NATIONAL CANCER INSTITUTE   (United States)

^g GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^h DALIAN MEDICAL UNIVERSITY   (China)

ⁱ Medical University   (China)

Author keywords

Adverse effects; Andrographolide derivatives; Herb drug interaction (HDI); UDP glucuronosyltransferases (UGTs)

Indexed keywords

3 OXO 9BETA HYDROXY DEOXYANDROGRAPHOLIDE; 3 OXO DEHYDROANDROGRAPHOLIDE; 3 OXO DEOXYANDROGRAPHOLIDE; 3,17,19 TRIHYDROXY 7,11,13, ENT LABDATRIEN 15,16 OLIDE; 9BETA HYDROXY DEHYDROANDROGRAPHOLIDE; 9BETA HYDROXY DEOXYANDROGRAPHOLIDE; ANDROGRAPHIS PANICULATA EXTRACT; ANDROGRAPHOLIDE; DEHYDROANDROGRAPHOLIDE; DEOXYANDROGRAPHOLIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B4; GLUCURONOSYLTRANSFERASE 2B7; HYMECROMONE; NEOANDROGRAPHOLIDE; TERPENOID DERIVATIVE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; ZIDOVUDINE;

ANDROGRAPHIS PANICULATA; ARTICLE; DRUG CONFORMATION; DRUG ELIMINATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCURONIDATION; HERB DRUG INTERACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME;

ADVERSE EFFECTS; ANDROGRAPHOLIDE DERIVATIVES; HERB-DRUG INTERACTION (HDI); UDP-GLUCURONOSYLTRANSFERASES (UGTS);

ANDROGRAPHIS; DITERPENES; ENZYME REPRESSION; GLUCURONOSYLTRANSFERASE; HERB-DRUG INTERACTIONS; HUMANS; MICROSOMES, LIVER;

EID: 84897945514     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.02.021     Document Type: Article

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