Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1757-1763

  Chatuphonprasert, Waranya ^a   Remsungnen, Tawun ^b   Nemoto, Nobuo ^c   Jarukamjorn, Kanokwan ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

^b Khon Kaen University   (Thailand)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

AhR; Andrographis paniculata; CYP1A1; Diterpenoids; Molecular docking

Indexed keywords

11,12 DIDEHYDRO 14 DEOXYANDROGRAPHOLIDE; ANDROGRAPHISIDE; ANDROGRAPHOLIDE; AROMATIC HYDROCARBON RECEPTOR; BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; DITERPENOID; MESSENGER RNA; NEOANDROGRAPHOLIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANDROGRAPHIS PANICULATA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; LIGAND BINDING; LIVER CELL; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION;

ANDROGRAPHIS; ANIMALS; BETA-NAPHTHOFLAVONE; BINDING SITES; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; DITERPENES; ENZYME INDUCTION; HEPATOCYTES; HERB-DRUG INTERACTIONS; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER;

ANDROGRAPHIS PANICULATA;

EID: 82655181780     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.09.004     Document Type: Article

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