Eudismic analysis of tricyclic sesquiterpenoid alcohols: Lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7

Bioorganic Chemistry

Volumn 35, Issue 5, 2007, Pages 386-400

  Bichlmaier, Ingo ^a   Kurkela, Mika ^a   Siiskonen, Antti ^a   Finel, Moshe ^a   Yli Kauhaluoma, Jari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Enzyme; Inhibition; Longifolene; Metabolism; Stereochemistry; UGT

Indexed keywords

ALCOHOL DERIVATIVE; CEDROL; EPICEDROL; EPIGLOBULOL; GLOBULOL; GLUCURONOSYLTRANSFERASE 2B7; HYDROCARBON; HYDROXYL GROUP; ISOLONGIFOLOL; LONGIFOLOL; METHYL GROUP; SESQUITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; COMPETITIVE INHIBITION; CONJUGATION; DISSOCIATION; ENZYME INHIBITION; ENZYME SUBSTRATE; GLUCURONIDATION; HYDROPHOBICITY; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOISOMERISM;

ALCOHOLS; CATALYSIS; CHEMISTRY, ORGANIC; DRUG DESIGN; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROCARBONS; INHIBITORY CONCENTRATION 50; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ISOFORMS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TERPENES; URIDINE DIPHOSPHATE;

EID: 34548124595     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2007.07.002     Document Type: Article

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