Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Kiffer Moreira, Tina ^a   Sheen, Campbell R ^a   Gasque, Kellen Cristina Da Silva ^a   Bolean, Mayte ^b   Ciancaglini, Pietro ^b   Van Elsas, Andrea ^c   Hoylaerts, Marc F ^d   Millán, José Luis ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c AM Pharma   (Netherlands)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE INTESTINE ISOENZYME; BACTERIUM LIPOPOLYSACCHARIDE; ISOENZYME; RECOMBINANT ALKALINE PHOSPHATASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ZINC ION; ALPI PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; RECOMBINANT PROTEIN;

ACUTE KIDNEY FAILURE; ARTICLE; CATALYSIS; CHIMERA; DRUG INDICATION; DRUG STRUCTURE; DYSBIOSIS; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; INFLAMMATORY BOWEL DISEASE; METAL BINDING; THERMOSTABILITY; AMINO ACID SEQUENCE; FEMALE; HEAT; HUMAN; METABOLISM; MOLECULAR GENETICS; PLACENTA; PREGNANCY; PROTEIN FOLDING; PROTEIN STABILITY;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; FEMALE; GPI-LINKED PROTEINS; HOT TEMPERATURE; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PLACENTA; PREGNANCY; PROTEIN FOLDING; PROTEIN STABILITY; RECOMBINANT PROTEINS;

EID: 84897904300     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089374     Document Type: Article

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