Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 292, Issue 5, 2007, Pages

  Nakano, Takanari ^a   Inoue, Ikuo ^a   Koyama, Iwao ^a   Kanazawa, Kenta ^a   Nakamura, Koh Ichi ^a   Narisawa, Sonoko ^b   Tanaka, Kayoko ^a   Akita, Masumi ^a   Masuyama, Taku ^c   Seo, Makoto ^a   Hokari, Shigeru ^a   Katayama, Shigehiro ^a   Alpers, David H ^d   Millán, José Luis ^b   Komoda, Tsugikazu ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b BURNHAM INSTITUTE   (United States)

^c Toxicology Research Laboratories   (Japan)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fat absorption; Metabolic abnormality; Obesity; Small intestine

Indexed keywords

ALKALINE PHOSPHATASE; CORN OIL; LIPID; TRIACYLGLYCEROL; TYLOXAPOL; AKP3 PROTEIN, MOUSE; LIPOPROTEIN LIPASE; MACROGOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FAT INTAKE; FATTY LIVER; FEEDING; FEMALE; GENE DISRUPTION; GOLGI COMPLEX; INTRAABDOMINAL FAT; LIPID ABSORPTION; LIPID DIET; LIPID STORAGE; LIPID TRANSPORT; MALE; MORPHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSCYTOSIS; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WILD TYPE; ANIMAL; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; INTESTINE ABSORPTION; LIPID METABOLISM; METABOLISM; SMALL INTESTINE;

ALKALINE PHOSPHATASE; ANIMALS; DIETARY FATS; FATTY LIVER; FEMALE; INTESTINAL ABSORPTION; INTESTINE, SMALL; INTRA-ABDOMINAL FAT; LIPID METABOLISM; LIPOPROTEIN LIPASE; MALE; MICE; POLYETHYLENE GLYCOLS; TRIGLYCERIDES;

EID: 34347406173     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00331.2006     Document Type: Article

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