Trehalose reverses cell malfunction in fibroblasts from normal and huntington's disease patients caused by proteosome inhibition

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Fernandez Estevez, Maria Angeles ^a,b   Casarejos, Maria Jose ^a,b   Sendon, Jose López ^a,b   Caldentey, Juan Garcia ^a   Ruiz, Carolina ^a,b   Gomez, Ana ^a,b   Perucho, Juan ^a,b   De Yebenes, Justo García ^a,b   Mena, Maria Angeles ^a,b  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CELL PROTEIN; EPOXOMICIN; HEAT SHOCK PROTEIN 70; HUNTINGTIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEASOME; PROTEIN LC3; REACTIVE OXYGEN METABOLITE; TREHALOSE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MACROAUTOPHAGY; NEUROPROTECTION; OXIDATIVE STRESS; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN PROCESSING; SKIN FIBROBLAST; UBIQUITINATION;

APOPTOSIS; AUTOPHAGY; CELL SURVIVAL; FIBROBLASTS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HUNTINGTON DISEASE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OLIGOPEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; REACTIVE OXYGEN SPECIES; TREHALOSE; UBIQUITINATION;

EID: 84897877237     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090202     Document Type: Article

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