Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

Journal of Neurochemistry

Volumn 78, Issue 3, 2001, Pages 600-610

  Seo, Su Ryeon ^a   Chong, Seon Ah ^a,b   Lee, Syng Ill ^a,b   Sung, Jee Young ^b   Ahn, Young Soo ^b   Chung, Kwang Chul ^b   Seo, Jeong Taeg ^a,b  

^a Yonsei University College of Dentistry   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

c Jun N terminal kinase; Extracellular signal regulated kinase; Mitogen activated protein kinases; Reactive oxygen species; Zn2+

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTIOXIDANT; IONOPHORE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR; PYRITHIONE; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG; ZINC; ZINC IONOPHORE; ANTIFUNGAL AGENT; BISINDOLYLMALEIMIDE I; ENZYME INHIBITOR; FLAVONOID; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; CELL DEATH; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; METAL BINDING; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SEIZURE; SIGNAL TRANSDUCTION; ANIMAL; APOPTOSIS; CELL STRAIN; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; IMMUNOBLOTTING; METABOLISM; NERVE CELL; PHYSIOLOGY; TIME;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIFUNGAL AGENTS; ANTIOXIDANTS; APOPTOSIS; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; IMMUNOBLOTTING; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALEIMIDES; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PROTEIN KINASE C; PYRIDINES; RAS PROTEINS; RATS; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRANSFECTION; ZINC;

EID: 0034903539     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00438.x     Document Type: Article

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