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Volumn 5, Issue FEB, 2014, Pages

Non-coding RNAs as epigenetic regulator of glioma stem-like cell differentiation

Author keywords

Cancer stem cells; Epigenetics; Glioma; Long non coding RNA; Micro RNA

Indexed keywords

BETA CATENIN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN DEPENDENT KINASE 6; MICRORNA; MICRORNA 124; MICRORNA 1275; MICRORNA 128; MICRORNA 137; MICRORNA 138; MICRORNA 17 92; MICRORNA 204; MICRORNA 302 327 CLUSTER; MICRORNA 34A; MICRORNA 451; NOTCH RECEPTOR; POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTEIN P53; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; UNTRANSLATED RNA; WNT PROTEIN;

EID: 84897731251     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2014.00014     Document Type: Short Survey
Times cited : (31)

References (105)
  • 1
    • 67650727135 scopus 로고    scopus 로고
    • BMI1 sustains human glioblastoma multiforme stem cell renewal
    • doi: 10.1523/JNEUROSCI.0968-09.2009
    • Abdouh, M., Facchino, S., Chatoo, W., Balasingam, V., Ferreira, J., and Bernier, G. (2009). BMI1 sustains human glioblastoma multiforme stem cell renewal. J. Neurosci. 29, 8884-8896. doi: 10.1523/JNEUROSCI.0968-09.2009.
    • (2009) J. Neurosci. , vol.29 , pp. 8884-8896
    • Abdouh, M.1    Facchino, S.2    Chatoo, W.3    Balasingam, V.4    Ferreira, J.5    Bernier, G.6
  • 2
    • 3142726606 scopus 로고    scopus 로고
    • Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning
    • doi: 10.1385/1-59259-775-0131
    • Ambros, V., and Lee, R. C. (2004). Identification of microRNAs and other tiny noncoding RNAs by cDNA cloning. Methods Mol. Biol. 265, 131-158. doi: 10.1385/1-59259-775-0131.
    • (2004) Methods Mol. Biol. , vol.265 , pp. 131-158
    • Ambros, V.1    Lee, R.C.2
  • 3
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • doi: 10.1016/S0092-8674(04)00045-5
    • Bartel, D. P. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297. doi: 10.1016/S0092-8674(04)00045-5.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 4
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • doi: 10.1038/nature05874
    • Birney, E., Stamatoyannopoulos, J. A., Dutta, A., Guigo, R., Gingeras, T. R., Margulies, E. H., et al. (2007). Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799-816. doi: 10.1038/nature05874.
    • (2007) Nature , vol.447 , pp. 799-816
    • Birney, E.1    Stamatoyannopoulos, J.A.2    Dutta, A.3    Guigo, R.4    Gingeras, T.R.5    Margulies, E.H.6
  • 5
    • 79551674253 scopus 로고    scopus 로고
    • Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma
    • doi: 10.1073/pnas.1011098108
    • Braconi, C., Valeri, N., Kogure, T., Gasparini, P., Huang, N., Nuovo, G. J., et al. (2011). Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. Proc. Natl. Acad. Sci. U.S.A. 108, 786-791. doi: 10.1073/pnas.1011098108.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 786-791
    • Braconi, C.1    Valeri, N.2    Kogure, T.3    Gasparini, P.4    Huang, N.5    Nuovo, G.J.6
  • 6
    • 34548230885 scopus 로고    scopus 로고
    • Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas
    • doi: 10.1016/j.ccr.2007.07.027
    • Calin, G. A., Liu, C. G., Ferracin, M., Hyslop, T., Spizzo, R., Sevignani, C., et al. (2007). Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 12, 215-229. doi: 10.1016/j.ccr.2007.07.027.
    • (2007) Cancer Cell , vol.12 , pp. 215-229
    • Calin, G.A.1    Liu, C.G.2    Ferracin, M.3    Hyslop, T.4    Spizzo, R.5    Sevignani, C.6
  • 7
    • 80054715378 scopus 로고    scopus 로고
    • A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA
    • doi: 10.1016/j.cell.2011.09.028
    • Cesana, M., Cacchiarelli, D., Legnini, I., Santini, T., Sthandier, O., Chinappi, M., et al. (2011). A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 147, 358-369. doi: 10.1016/j.cell.2011.09.028.
    • (2011) Cell , vol.147 , pp. 358-369
    • Cesana, M.1    Cacchiarelli, D.2    Legnini, I.3    Santini, T.4    Sthandier, O.5    Chinappi, M.6
  • 8
    • 84866905323 scopus 로고    scopus 로고
    • Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas
    • doi: 10.1016/j.celrep.2012.07.012
    • Chan, X. H., Nama, S., Gopal, F., Rizk, P., Ramasamy, S., Sundaram, G., et al. (2012). Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas. Cell Rep. 2, 591-602. doi: 10.1016/j.celrep.2012.07.012.
    • (2012) Cell Rep. , vol.2 , pp. 591-602
    • Chan, X.H.1    Nama, S.2    Gopal, F.3    Rizk, P.4    Ramasamy, S.5    Sundaram, G.6
  • 9
    • 78650200618 scopus 로고    scopus 로고
    • Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility
    • doi: 10.1111/j.1349-7006.2010.01737.x
    • Chung, S., Nakagawa, H., Uemura, M., Piao, L., Ashikawa, K., Hosono, N., et al. (2011). Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Sci. 102, 245-252. doi: 10.1111/j.1349-7006.2010.01737.x.
    • (2011) Cancer Sci. , vol.102 , pp. 245-252
    • Chung, S.1    Nakagawa, H.2    Uemura, M.3    Piao, L.4    Ashikawa, K.5    Hosono, N.6
  • 10
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • doi: 10.1016/j.cub.2006.11.033
    • Clement, V., Sanchez, P., De Tribolet, N., Radovanovic, I., and Ruiz I Altaba, A. (2007). HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 17, 165-172. doi: 10.1016/j.cub.2006.11.033.
    • (2007) Curr. Biol. , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    De Tribolet, N.3    Radovanovic, I.4    Ruiz, I.5    Altaba, A.6
  • 11
    • 84865727393 scopus 로고    scopus 로고
    • The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
    • doi: 10.1101/gr.132159.111
    • Derrien, T., Johnson, R., Bussotti, G., Tanzer, A., Djebali, S., Tilgner, H., et al. (2012). The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775-1789. doi: 10.1101/gr.132159.111.
    • (2012) Genome Res. , vol.22 , pp. 1775-1789
    • Derrien, T.1    Johnson, R.2    Bussotti, G.3    Tanzer, A.4    Djebali, S.5    Tilgner, H.6
  • 12
    • 84876076478 scopus 로고    scopus 로고
    • CRNDE:a long non-coding RNA involved in cancer, neurobiology, and development
    • doi: 10.3389/fgene.2012.00270
    • Ellis, B. C., Molloy, P. L., and Graham, L. D. (2012). CRNDE:a long non-coding RNA involved in cancer, neurobiology, and development. Front. Genet. 3:270. doi: 10.3389/fgene.2012.00270.
    • (2012) Front. Genet. , vol.3 , pp. 270
    • Ellis, B.C.1    Molloy, P.L.2    Graham, L.D.3
  • 13
    • 77953478056 scopus 로고    scopus 로고
    • De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures
    • doi: 10.1038/onc.2010.83
    • Ernst, A., Campos, B., Meier, J., Devens, F., Liesenberg, F., Wolter, M., et al. (2010). De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures. Oncogene 29, 3411-3422. doi: 10.1038/onc.2010.83.
    • (2010) Oncogene , vol.29 , pp. 3411-3422
    • Ernst, A.1    Campos, B.2    Meier, J.3    Devens, F.4    Liesenberg, F.5    Wolter, M.6
  • 14
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • doi: 10.1038/nrg3074
    • Esteller, M. (2011). Non-coding RNAs in human disease. Nat. Rev. Genet. 12, 861-874. doi: 10.1038/nrg3074.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 861-874
    • Esteller, M.1
  • 15
    • 75349105363 scopus 로고    scopus 로고
    • NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
    • doi: 10.1002/stem.254
    • Fan, X., Khaki, L., Zhu, T. S., Soules, M. E., Talsma, C. E., Gul, N., et al. (2010). NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells 28, 5-16. doi: 10.1002/stem.254.
    • (2010) Stem Cells , vol.28 , pp. 5-16
    • Fan, X.1    Khaki, L.2    Zhu, T.S.3    Soules, M.E.4    Talsma, C.E.5    Gul, N.6
  • 16
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • doi: 10.1158/0008-5472.CAN-06-0858
    • Fan, X., Matsui, W., Khaki, L., Stearns, D., Chun, J., Li, Y. M., et al. (2006). Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res. 66, 7445-7452. doi: 10.1158/0008-5472.CAN-06-0858.
    • (2006) Cancer Res. , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.M.6
  • 17
    • 84855685116 scopus 로고    scopus 로고
    • The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network
    • doi: 10.1038/cdd.2011.89
    • Fareh, M., Turchi, L., Virolle, V., Debruyne, D., Almairac, F., De-La-Forest Divonne, S., et al. (2012). The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. Cell Death Differ. 19, 232-244. doi: 10.1038/cdd.2011.89.
    • (2012) Cell Death Differ. , vol.19 , pp. 232-244
    • Fareh, M.1    Turchi, L.2    Virolle, V.3    Debruyne, D.4    Almairac, F.5    De-La-Forest Divonne, S.6
  • 18
    • 33846466076 scopus 로고    scopus 로고
    • Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment
    • doi: 10.1016/j.nec.2006.10.006
    • Fomchenko, E. I., and Holland, E. C. (2007). Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment. Neurosurg. Clin. N. Am. 18, 39-58; viii. doi: 10.1016/j.nec.2006.10.006.
    • (2007) Neurosurg. Clin. N. Am. , vol.18 , pp. 39-58
    • Fomchenko, E.I.1    Holland, E.C.2
  • 19
    • 33645454706 scopus 로고    scopus 로고
    • The H19 gene: regulation and function of a non-coding RNA
    • doi: 10.1159/000090831
    • Gabory, A., Ripoche, M. A., Yoshimizu, T., and Dandolo, L. (2006). The H19 gene: regulation and function of a non-coding RNA. Cytogenet. Genome Res. 113, 188-193. doi: 10.1159/000090831.
    • (2006) Cytogenet. Genome Res. , vol.113 , pp. 188-193
    • Gabory, A.1    Ripoche, M.A.2    Yoshimizu, T.3    Dandolo, L.4
  • 20
    • 52049096593 scopus 로고    scopus 로고
    • MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells
    • doi: 10.1016/j.bbrc.2008.08.107
    • Gal, H., Pandi, G., Kanner, A. A., Ram, Z., Lithwick-Yanai, G., Amariglio, N., et al. (2008). MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. Biochem. Biophys. Res. Commun. 376, 86-90. doi: 10.1016/j.bbrc.2008.08.107.
    • (2008) Biochem. Biophys. Res. Commun. , vol.376 , pp. 86-90
    • Gal, H.1    Pandi, G.2    Kanner, A.A.3    Ram, Z.4    Lithwick-Yanai, G.5    Amariglio, N.6
  • 21
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • doi: 10.1158/0008-5472.CAN-04-1364
    • Galli, R., Binda, E., Orfanelli, U., Cipelletti, B., Gritti, A., De Vitis, S., et al. (2004). Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 64, 7011-7021. doi: 10.1158/0008-5472.CAN-04-1364.
    • (2004) Cancer Res. , vol.64 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3    Cipelletti, B.4    Gritti, A.5    De Vitis, S.6
  • 22
    • 58849163959 scopus 로고    scopus 로고
    • MicroRNAs: key regulators of stem cells
    • doi: 10.1038/nrm2621
    • Gangaraju, V. K., and Lin, H. (2009). MicroRNAs: key regulators of stem cells. Nat. Rev. Mol. Cell Biol. 10, 116-125. doi: 10.1038/nrm2621.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 116-125
    • Gangaraju, V.K.1    Lin, H.2
  • 23
    • 74249114116 scopus 로고    scopus 로고
    • MicroRNAs and glioblastoma; the stem cell connection
    • doi: 10.1038/cdd.2009.71
    • Godlewski, J., Newton, H., Chiocca, E., and Lawler, S. (2010a). MicroRNAs and glioblastoma; the stem cell connection. Cell Death Differ. 17, 221-228. doi: 10.1038/cdd.2009.71.
    • (2010) Cell Death Differ. , vol.17 , pp. 221-228
    • Godlewski, J.1    Newton, H.2    Chiocca, E.3    Lawler, S.4
  • 24
    • 77649259296 scopus 로고    scopus 로고
    • MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells
    • doi: 10.1016/j.molcel.2010.02.018
    • Godlewski, J., Nowicki, M. O., Bronisz, A., Nuovo, G., Palatini, J., De Lay, M., et al. (2010b). MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol. Cell 37, 620-632. doi: 10.1016/j.molcel.2010.02.018.
    • (2010) Mol. Cell , vol.37 , pp. 620-632
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3    Nuovo, G.4    Palatini, J.5    De Lay, M.6
  • 25
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • doi: 10.1158/0008-5472.CAN-08-2629
    • Godlewski, J., Nowicki, M. O., Bronisz, A., Williams, S., Otsuki, A., Nuovo, G., et al. (2008). Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 68, 9125-9130. doi: 10.1158/0008-5472.CAN-08-2629.
    • (2008) Cancer Res. , vol.68 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3    Williams, S.4    Otsuki, A.5    Nuovo, G.6
  • 26
    • 77953498262 scopus 로고    scopus 로고
    • microRNA-34a is tumor suppressive in brain tumors and glioma stem cells
    • doi: 10.4161/cc.9.6.10987
    • Guessous, F., Zhang, Y., Kofman, A., Catania, A., Li, Y., Schiff, D., et al. (2010). microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle 9, 1031-1036. doi: 10.4161/cc.9.6.10987.
    • (2010) Cell Cycle , vol.9 , pp. 1031-1036
    • Guessous, F.1    Zhang, Y.2    Kofman, A.3    Catania, A.4    Li, Y.5    Schiff, D.6
  • 27
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • doi: 10.1016/j.cell.2011.07.026
    • Gupta, P. B., Fillmore, C. M., Jiang, G., Shapira, S. D., Tao, K., Kuperwasser, C., et al. (2011). Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 146, 633-644. doi: 10.1016/j.cell.2011.07.026.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6
  • 28
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • doi: 10.1038/nature08975
    • Gupta, R. A., Shah, N., Wang, K. C., Kim, J., Horlings, H. M., Wong, D. J., et al. (2010). Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464, 1071-1076. doi: 10.1038/nature08975.
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1    Shah, N.2    Wang, K.C.3    Kim, J.4    Horlings, H.M.5    Wong, D.J.6
  • 29
    • 70449099233 scopus 로고    scopus 로고
    • Brain cancer propagating cells: biology, genetics and targeted therapies
    • doi: 10.1016/j.molmed.2009.09.003
    • Hadjipanayis, C. G., and Van Meir, E. G. (2009). Brain cancer propagating cells: biology, genetics and targeted therapies. Trends Mol. Med. 15, 519-530. doi: 10.1016/j.molmed.2009.09.003.
    • (2009) Trends Mol. Med. , vol.15 , pp. 519-530
    • Hadjipanayis, C.G.1    Van Meir, E.G.2
  • 30
    • 84868683051 scopus 로고    scopus 로고
    • Regulation of mammalian cell differentiation by long non-coding RNAs
    • doi: 10.1038/embor.2012.145
    • Hu, W., Alvarez-Dominguez, J. R., and Lodish, H. F. (2012). Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep. 13, 971-983. doi: 10.1038/embor.2012.145.
    • (2012) EMBO Rep. , vol.13 , pp. 971-983
    • Hu, W.1    Alvarez-Dominguez, J.R.2    Lodish, H.F.3
  • 31
    • 79951780026 scopus 로고    scopus 로고
    • Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells
    • doi: 10.1186/1471-2407-11-82
    • Hu, Y. Y., Zheng, M. H., Cheng, G., Li, L., Liang, L., Gao, F., et al. (2011). Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells. BMC Cancer 11:82. doi: 10.1186/1471-2407-11-82.
    • (2011) BMC Cancer , vol.11 , pp. 82
    • Hu, Y.Y.1    Zheng, M.H.2    Cheng, G.3    Li, L.4    Liang, L.5    Gao, F.6
  • 32
    • 77955323879 scopus 로고    scopus 로고
    • A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
    • doi: 10.1016/j.cell.2010.06.040
    • Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M. J., Kenzelmann-Broz, D., et al. (2010). A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142, 409-419. doi: 10.1016/j.cell.2010.06.040.
    • (2010) Cell , vol.142 , pp. 409-419
    • Huarte, M.1    Guttman, M.2    Feldser, D.3    Garber, M.4    Koziol, M.J.5    Kenzelmann-Broz, D.6
  • 33
    • 0344429906 scopus 로고    scopus 로고
    • MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer
    • doi: 10.1038/sj.onc.1206928
    • Ji, P., Diederichs, S., Wang, W., Boing, S., Metzger, R., Schneider, P. M., et al. (2003). MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22, 8031-8041. doi: 10.1038/sj.onc.1206928.
    • (2003) Oncogene , vol.22 , pp. 8031-8041
    • Ji, P.1    Diederichs, S.2    Wang, W.3    Boing, S.4    Metzger, R.5    Schneider, P.M.6
  • 34
    • 34249088350 scopus 로고    scopus 로고
    • Genome-wide transcription and the implications for genomic organization
    • doi: 10.1038/nrg2083
    • Kapranov, P., Willingham, A. T., and Gingeras, T. R. (2007). Genome-wide transcription and the implications for genomic organization. Nat. Rev. Genet. 8, 413-423. doi: 10.1038/nrg2083.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 413-423
    • Kapranov, P.1    Willingham, A.T.2    Gingeras, T.R.3
  • 35
    • 80054681545 scopus 로고    scopus 로고
    • In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma
    • doi: 10.1016/j.cell.2011.09.032
    • Karreth, F. A., Tay, Y., Perna, D., Ala, U., Tan, S. M., Rust, A. G., et al. (2011). In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147, 382-395. doi: 10.1016/j.cell.2011.09.032.
    • (2011) Cell , vol.147 , pp. 382-395
    • Karreth, F.A.1    Tay, Y.2    Perna, D.3    Ala, U.4    Tan, S.M.5    Rust, A.G.6
  • 36
    • 84864992390 scopus 로고    scopus 로고
    • Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells
    • doi: 10.1074/jbc.M112.359109
    • Katsushima, K., Shinjo, K., Natsume, A., Ohka, F., Fujii, M., Osada, H., et al. (2012). Contribution of microRNA-1275 to Claudin11 protein suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells. J. Biol. Chem. 287, 27396-27406. doi: 10.1074/jbc.M112.359109.
    • (2012) J. Biol. Chem. , vol.287 , pp. 27396-27406
    • Katsushima, K.1    Shinjo, K.2    Natsume, A.3    Ohka, F.4    Fujii, M.5    Osada, H.6
  • 37
    • 79957907741 scopus 로고    scopus 로고
    • The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion
    • doi: 10.1158/0008-5472.CAN-10-4460
    • Khaitan, D., Dinger, M. E., Mazar, J., Crawford, J., Smith, M. A., Mattick, J. S., et al. (2011). The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Res. 71, 3852-3862. doi: 10.1158/0008-5472.CAN-10-4460.
    • (2011) Cancer Res. , vol.71 , pp. 3852-3862
    • Khaitan, D.1    Dinger, M.E.2    Mazar, J.3    Crawford, J.4    Smith, M.A.5    Mattick, J.S.6
  • 38
    • 84875890253 scopus 로고    scopus 로고
    • HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
    • doi: 10.1038/onc.2012.193
    • Kim, K., Jutooru, I., Chadalapaka, G., Johnson, G., Frank, J., Burghardt, R., et al. (2013). HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 32, 1616-1625. doi: 10.1038/onc.2012.193.
    • (2013) Oncogene , vol.32 , pp. 1616-1625
    • Kim, K.1    Jutooru, I.2    Chadalapaka, G.3    Johnson, G.4    Frank, J.5    Burghardt, R.6
  • 39
    • 77951638287 scopus 로고    scopus 로고
    • Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor
    • doi: 10.1126/scisignal.2000568
    • Kino, T., Hurt, D. E., Ichijo, T., Nader, N., and Chrousos, G. P. (2010). Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci. Signal. 3, ra8. doi: 10.1126/scisignal.2000568.
    • (2010) Sci. Signal. , vol.3
    • Kino, T.1    Hurt, D.E.2    Ichijo, T.3    Nader, N.4    Chrousos, G.P.5
  • 40
    • 80054029971 scopus 로고    scopus 로고
    • Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers
    • doi: 10.1158/0008-5472.CAN-11-1021
    • Kogo, R., Shimamura, T., Mimori, K., Kawahara, K., Imoto, S., Sudo, T., et al. (2011). Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71, 6320-6326. doi: 10.1158/0008-5472.CAN-11-1021.
    • (2011) Cancer Res. , vol.71 , pp. 6320-6326
    • Kogo, R.1    Shimamura, T.2    Mimori, K.3    Kawahara, K.4    Imoto, S.5    Sudo, T.6
  • 41
    • 77952212771 scopus 로고    scopus 로고
    • RNA traffic control of chromatin complexes
    • doi: 10.1016/j.gde.2010.03.003
    • Koziol, M. J., and Rinn, J. L. (2010). RNA traffic control of chromatin complexes. Curr. Opin. Genet. Dev. 20, 142-148. doi: 10.1016/j.gde.2010.03.003.
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 142-148
    • Koziol, M.J.1    Rinn, J.L.2
  • 42
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • doi: 10.1016/j.ccr.2006.03.030
    • Lee, J., Kotliarova, S., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., et al. (2006). Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 391-403. doi: 10.1016/j.ccr.2006.03.030.
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3    Li, A.4    Su, Q.5    Donin, N.M.6
  • 43
    • 61449191698 scopus 로고    scopus 로고
    • EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors
    • doi: 10.1215/15228517-2008-2081
    • Li, L., Dutra, A., Pak, E., Labrie, J. E. III, Gerstein, R. M., Pandolfi, P. P., et al. (2009a). EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors. Neurooncology 11, 9-21. doi: 10.1215/15228517-2008-2081.
    • (2009) Neurooncology , vol.11 , pp. 9-21
    • Li, L.1    Dutra, A.2    Pak, E.3    Labrie III, J.E.4    Gerstein, R.M.5    Pandolfi, P.P.6
  • 44
    • 70350221952 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
    • doi: 10.1158/0008-5472.CAN-09-0529
    • Li, Y., Guessous, F., Zhang, Y., Dipierro, C., Kefas, B., Johnson, E., et al. (2009b). MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res. 69, 7569-7576. doi: 10.1158/0008-5472.CAN-09-0529.
    • (2009) Cancer Res. , vol.69 , pp. 7569-7576
    • Li, Y.1    Guessous, F.2    Zhang, Y.3    Dipierro, C.4    Kefas, B.5    Johnson, E.6
  • 45
    • 80052536392 scopus 로고    scopus 로고
    • RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders
    • doi: 10.1371/journal.pone.0023356
    • Lin, M., Pedrosa, E., Shah, A., Hrabovsky, A., Maqbool, S., Zheng, D., et al. (2011). RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. PLoS ONE 6:e23356. doi: 10.1371/journal.pone.0023356.
    • (2011) PLoS ONE , vol.6
    • Lin, M.1    Pedrosa, E.2    Shah, A.3    Hrabovsky, A.4    Maqbool, S.5    Zheng, D.6
  • 46
    • 33846950027 scopus 로고    scopus 로고
    • A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas
    • doi: 10.1038/sj.onc.1209846
    • Lin, R., Maeda, S., Liu, C., Karin, M., and Edgington, T. S. (2007). A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene 26, 851-858. doi: 10.1038/sj.onc.1209846.
    • (2007) Oncogene , vol.26 , pp. 851-858
    • Lin, R.1    Maeda, S.2    Liu, C.3    Karin, M.4    Edgington, T.S.5
  • 47
    • 84885015533 scopus 로고    scopus 로고
    • Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression
    • doi: 10.1186/1471-2407-13-461
    • Lu, K. H., Li, W., Liu, X. H., Sun, M., Zhang, M. L., Wu, W. Q., et al. (2013). Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. BMC Cancer 13:461. doi: 10.1186/1471-2407-13-461.
    • (2013) BMC Cancer , vol.13 , pp. 461
    • Lu, K.H.1    Li, W.2    Liu, X.H.3    Sun, M.4    Zhang, M.L.5    Wu, W.Q.6
  • 48
    • 2342475666 scopus 로고    scopus 로고
    • Polycomb complexes and silencing mechanisms
    • doi: 10.1016/j.ceb.2004.03.010
    • Lund, A. H., and van Lohuizen, M. (2004). Polycomb complexes and silencing mechanisms. Curr. Opin. Cell Biol. 16, 239-246. doi: 10.1016/j.ceb.2004.03.010.
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 239-246
    • Lund, A.H.1    van Lohuizen, M.2
  • 49
    • 34547212309 scopus 로고    scopus 로고
    • The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing
    • doi: 10.1016/j.molcel.2007.07.015
    • Makeyev, E. V., Zhang, J., Carrasco, M. A., and Maniatis, T. (2007). The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol. Cell 27, 435-448. doi: 10.1016/j.molcel.2007.07.015.
    • (2007) Mol. Cell , vol.27 , pp. 435-448
    • Makeyev, E.V.1    Zhang, J.2    Carrasco, M.A.3    Maniatis, T.4
  • 50
    • 37149033830 scopus 로고    scopus 로고
    • The H19 non-coding RNA is essential for human tumor growth
    • doi: 10.1371/journal.pone.0000845
    • Matouk, I. J., Degroot, N., Mezan, S., Ayesh, S., Abu-Lail, R., Hochberg, A., et al. (2007). The H19 non-coding RNA is essential for human tumor growth. PLoS ONE 2:e845. doi: 10.1371/journal.pone.0000845.
    • (2007) PLoS ONE , vol.2
    • Matouk, I.J.1    Degroot, N.2    Mezan, S.3    Ayesh, S.4    Abu-Lail, R.5    Hochberg, A.6
  • 51
    • 77957351780 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis
    • doi: 10.1158/0008-5472.CAN-10-2353
    • Mazzoleni, S., Politi, L. S., Pala, M., Cominelli, M., Franzin, A., Sergi Sergi, L., et al. (2010). Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis. Cancer Res. 70, 7500-7513. doi: 10.1158/0008-5472.CAN-10-2353.
    • (2010) Cancer Res. , vol.70 , pp. 7500-7513
    • Mazzoleni, S.1    Politi, L.S.2    Pala, M.3    Cominelli, M.4    Franzin, A.5    Sergi Sergi, L.6
  • 52
    • 49749150573 scopus 로고    scopus 로고
    • microRNAs and cancer: an overview
    • doi: 10.4161/cc.7.16.6453
    • Medina, P. P., and Slack, F. J. (2008). microRNAs and cancer: an overview. Cell Cycle 7, 2485-2492. doi: 10.4161/cc.7.16.6453.
    • (2008) Cell Cycle , vol.7 , pp. 2485-2492
    • Medina, P.P.1    Slack, F.J.2
  • 53
    • 60349120914 scopus 로고    scopus 로고
    • Long non-coding RNAs: insights into functions
    • doi: 10.1038/nrg2521
    • Mercer, T. R., Dinger, M. E., and Mattick, J. S. (2009). Long non-coding RNAs: insights into functions. Nat. Rev. Genet. 10, 155-159. doi: 10.1038/nrg2521.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 155-159
    • Mercer, T.R.1    Dinger, M.E.2    Mattick, J.S.3
  • 54
    • 58249098615 scopus 로고    scopus 로고
    • GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer
    • doi: 10.1038/onc.2008.373
    • Mourtada-Maarabouni, M., Pickard, M., Hedge, V., Farzaneh, F., and Williams, G. (2008). GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 28, 195-208. doi: 10.1038/onc.2008.373.
    • (2008) Oncogene , vol.28 , pp. 195-208
    • Mourtada-Maarabouni, M.1    Pickard, M.2    Hedge, V.3    Farzaneh, F.4    Williams, G.5
  • 55
    • 8444251099 scopus 로고    scopus 로고
    • Genome-wide screening for prognosis-predicting genes in early-stage non-small-cell lung cancer
    • doi: 10.1016/j.lungcan.2004.07.979
    • Muller-Tidow, C., Diederichs, S., Thomas, M., and Serve, H. (2004). Genome-wide screening for prognosis-predicting genes in early-stage non-small-cell lung cancer. Lung Cancer 45(Suppl. 2), S145-S150. doi: 10.1016/j.lungcan.2004.07.979.
    • (2004) Lung Cancer , vol.45 , Issue.SUPPL. 2
    • Muller-Tidow, C.1    Diederichs, S.2    Thomas, M.3    Serve, H.4
  • 56
    • 56549111129 scopus 로고    scopus 로고
    • The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin
    • doi: 10.1126/science.1163802
    • Nagano, T., Mitchell, J. A., Sanz, L. A., Pauler, F. M., Ferguson-Smith, A. C., Feil, R., et al. (2008). The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science 322, 1717-1720. doi: 10.1126/science.1163802.
    • (2008) Science , vol.322 , pp. 1717-1720
    • Nagano, T.1    Mitchell, J.A.2    Sanz, L.A.3    Pauler, F.M.4    Ferguson-Smith, A.C.5    Feil, R.6
  • 57
    • 84871145562 scopus 로고    scopus 로고
    • Beta-Catenin signalling in glioblastoma multiforme and glioma-initiating cells
    • doi: 10.1155/2012/192362
    • Nager, M., Bhardwaj, D., Canti, C., Medina, L., Nogues, P., and Herreros, J. (2012). Beta-Catenin signalling in glioblastoma multiforme and glioma-initiating cells. Chemother. Res. Pract. 2012, 192362. doi: 10.1155/2012/192362.
    • (2012) Chemother. Res. Pract. , vol.2012 , pp. 192362
    • Nager, M.1    Bhardwaj, D.2    Canti, C.3    Medina, L.4    Nogues, P.5    Herreros, J.6
  • 58
    • 84880857612 scopus 로고    scopus 로고
    • Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma
    • doi: 10.1158/0008-5472.CAN-13-0109
    • Natsume, A., Ito, M., Katsushima, K., Ohka, F., Hatanaka, A., Shinjo, K., et al. (2013). Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma. Cancer Res. 73, 4559-4570. doi: 10.1158/0008-5472.CAN-13-0109.
    • (2013) Cancer Res. , vol.73 , pp. 4559-4570
    • Natsume, A.1    Ito, M.2    Katsushima, K.3    Ohka, F.4    Hatanaka, A.5    Shinjo, K.6
  • 59
    • 84856492490 scopus 로고    scopus 로고
    • Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors
    • doi: 10.1038/emboj.2011.459
    • Ng, S. Y., Johnson, R., and Stanton, L. W. (2012). Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J. 31, 522-533. doi: 10.1038/emboj.2011.459.
    • (2012) EMBO J. , vol.31 , pp. 522-533
    • Ng, S.Y.1    Johnson, R.2    Stanton, L.W.3
  • 60
    • 84863393119 scopus 로고    scopus 로고
    • Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors
    • doi: 10.1158/0008-5472.CAN-11-1803
    • Niinuma, T., Suzuki, H., Nojima, M., Nosho, K., Yamamoto, H., Takamaru, H., et al. (2012). Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors. Cancer Res. 72, 1126-1136. doi: 10.1158/0008-5472.CAN-11-1803.
    • (2012) Cancer Res. , vol.72 , pp. 1126-1136
    • Niinuma, T.1    Suzuki, H.2    Nojima, M.3    Nosho, K.4    Yamamoto, H.5    Takamaru, H.6
  • 61
    • 54049138948 scopus 로고    scopus 로고
    • Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation
    • doi: 10.1016/j.molcel.2008.08.022
    • Pandey, R. R., Mondal, T., Mohammad, F., Enroth, S., Redrup, L., Komorowski, J., et al. (2008). Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol. Cell 32, 232-246. doi: 10.1016/j.molcel.2008.08.022.
    • (2008) Mol. Cell , vol.32 , pp. 232-246
    • Pandey, R.R.1    Mondal, T.2    Mohammad, F.3    Enroth, S.4    Redrup, L.5    Komorowski, J.6
  • 62
    • 34248547495 scopus 로고    scopus 로고
    • Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF
    • doi: 10.1158/0008-5472.CAN-06-2004
    • Pasmant, E., Laurendeau, I., Heron, D., Vidaud, M., Vidaud, D., and Bieche, I. (2007). Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res. 67, 3963-3969. doi: 10.1158/0008-5472.CAN-06-2004.
    • (2007) Cancer Res. , vol.67 , pp. 3963-3969
    • Pasmant, E.1    Laurendeau, I.2    Heron, D.3    Vidaud, M.4    Vidaud, D.5    Bieche, I.6
  • 63
    • 79551623370 scopus 로고    scopus 로고
    • ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
    • doi: 10.1096/fj.10-172452
    • Pasmant, E., Sabbagh, A., Vidaud, M., and Bieche, I. (2011). ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J. 25, 444-448. doi: 10.1096/fj.10-172452.
    • (2011) FASEB J. , vol.25 , pp. 444-448
    • Pasmant, E.1    Sabbagh, A.2    Vidaud, M.3    Bieche, I.4
  • 64
    • 63249123273 scopus 로고    scopus 로고
    • TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma
    • doi: 10.1016/j.ccr.2009.02.011
    • Penuelas, S., Anido, J., Prieto-Sanchez, R. M., Folch, G., Barba, I., Cuartas, I., et al. (2009). TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 15, 315-327. doi: 10.1016/j.ccr.2009.02.011.
    • (2009) Cancer Cell , vol.15 , pp. 315-327
    • Penuelas, S.1    Anido, J.2    Prieto-Sanchez, R.M.3    Folch, G.4    Barba, I.5    Cuartas, I.6
  • 65
    • 77957680712 scopus 로고    scopus 로고
    • Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
    • doi: 10.1073/pnas.1002530107
    • Pereira, J. D., Sansom, S. N., Smith, J., Dobenecker, M. W., Tarakhovsky, A., and Livesey, F. J. (2010). Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc. Natl. Acad. Sci. U.S.A. 107, 15957-15962. doi: 10.1073/pnas.1002530107.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 15957-15962
    • Pereira, J.D.1    Sansom, S.N.2    Smith, J.3    Dobenecker, M.W.4    Tarakhovsky, A.5    Livesey, F.J.6
  • 66
    • 84883189850 scopus 로고    scopus 로고
    • MicroRNA-128 coordinately targets polycomb repressor complexes in glioma stem cells
    • doi: 10.1093/neuonc/not055
    • Peruzzi, P., Bronisz, A., Nowicki, M. O., Wang, Y., Ogawa, D., Price, R., et al. (2013). MicroRNA-128 coordinately targets polycomb repressor complexes in glioma stem cells. Neurooncology 15, 1212-1224. doi: 10.1093/neuonc/not055.
    • (2013) Neurooncology , vol.15 , pp. 1212-1224
    • Peruzzi, P.1    Bronisz, A.2    Nowicki, M.O.3    Wang, Y.4    Ogawa, D.5    Price, R.6
  • 67
    • 10744225687 scopus 로고    scopus 로고
    • Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients
    • doi: 10.1038/sj.onc.1207069
    • Petrovics, G., Zhang, W., Makarem, M., Street, J. P., Connelly, R., Sun, L., et al. (2004). Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Oncogene 23, 605-611. doi: 10.1038/sj.onc.1207069.
    • (2004) Oncogene , vol.23 , pp. 605-611
    • Petrovics, G.1    Zhang, W.2    Makarem, M.3    Street, J.P.4    Connelly, R.5    Sun, L.6
  • 68
    • 33845610993 scopus 로고    scopus 로고
    • Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    • doi: 10.1038/nature05349
    • Piccirillo, S. G., Reynolds, B. A., Zanetti, N., Lamorte, G., Binda, E., Broggi, G., et al. (2006). Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444, 761-765. doi: 10.1038/nature05349.
    • (2006) Nature , vol.444 , pp. 761-765
    • Piccirillo, S.G.1    Reynolds, B.A.2    Zanetti, N.3    Lamorte, G.4    Binda, E.5    Broggi, G.6
  • 69
    • 77953957633 scopus 로고    scopus 로고
    • A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
    • doi: 10.1038/nature09144
    • Poliseno, L., Salmena, L., Zhang, J., Carver, B., Haveman, W. J., and Pandolfi, P. P. (2010). A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465, 1033-1038. doi: 10.1038/nature09144.
    • (2010) Nature , vol.465 , pp. 1033-1038
    • Poliseno, L.1    Salmena, L.2    Zhang, J.3    Carver, B.4    Haveman, W.J.5    Pandolfi, P.P.6
  • 70
    • 60149099385 scopus 로고    scopus 로고
    • Evolution and functions of long noncoding RNAs
    • doi: 10.1016/j.cell.2009.02.006
    • Ponting, C. P., Oliver, P. L., and Reik, W. (2009). Evolution and functions of long noncoding RNAs. Cell 136, 629-641. doi: 10.1016/j.cell.2009.02.006.
    • (2009) Cell , vol.136 , pp. 629-641
    • Ponting, C.P.1    Oliver, P.L.2    Reik, W.3
  • 71
    • 78449243068 scopus 로고    scopus 로고
    • Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health
    • doi: 10.4161/epi.5.8.12996
    • Popov, N., and Gil, J. (2010). Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health. Epigenetics 5, 685-690. doi: 10.4161/epi.5.8.12996.
    • (2010) Epigenetics , vol.5 , pp. 685-690
    • Popov, N.1    Gil, J.2
  • 72
    • 82155186923 scopus 로고    scopus 로고
    • The emergence of lncRNAs in cancer biology
    • doi: 10.1158/2159-8290.CD-11-0209
    • Prensner, J. R., and Chinnaiyan, A. M. (2011). The emergence of lncRNAs in cancer biology. Cancer Discov. 1, 391-407. doi: 10.1158/2159-8290.CD-11-0209.
    • (2011) Cancer Discov. , vol.1 , pp. 391-407
    • Prensner, J.R.1    Chinnaiyan, A.M.2
  • 73
    • 79961202865 scopus 로고    scopus 로고
    • Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression
    • doi: 10.1038/nbt.1914
    • Prensner, J. R., Iyer, M. K., Balbin, O. A., Dhanasekaran, S. M., Cao, Q., Brenner, J. C., et al. (2011). Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat. Biotechnol. 29, 742-749. doi: 10.1038/nbt.1914.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 742-749
    • Prensner, J.R.1    Iyer, M.K.2    Balbin, O.A.3    Dhanasekaran, S.M.4    Cao, Q.5    Brenner, J.C.6
  • 74
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • doi: 10.1038/nature03319
    • Reya, T., and Clevers, H. (2005). Wnt signalling in stem cells and cancer. Nature 434, 843-850. doi: 10.1038/nature03319.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 75
    • 80053427396 scopus 로고    scopus 로고
    • Roles of the Polycomb group proteins in stem cells and cancer
    • doi: 10.1038/cddis.2011.84
    • Richly, H., Aloia, L., and Di Croce, L. (2011). Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis. 2, e204. doi: 10.1038/cddis.2011.84.
    • (2011) Cell Death Dis. , vol.2
    • Richly, H.1    Aloia, L.2    Di Croce, L.3
  • 76
    • 53549097349 scopus 로고    scopus 로고
    • MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
    • doi: 10.1038/onc.2008.274
    • Schickel, R., Boyerinas, B., Park, S., and Peter, M. (2008). MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27, 5959-5974. doi: 10.1038/onc.2008.274.
    • (2008) Oncogene , vol.27 , pp. 5959-5974
    • Schickel, R.1    Boyerinas, B.2    Park, S.3    Peter, M.4
  • 77
    • 84869051680 scopus 로고    scopus 로고
    • Perturbation of chromatin structure globally affects localization and recruitment of splicing factors
    • doi: 10.1371/journal.pone.0048084
    • Schor, I. E., Lleres, D., Risso, G. J., Pawellek, A., Ule, J., Lamond, A. I., et al. (2012). Perturbation of chromatin structure globally affects localization and recruitment of splicing factors. PLoS ONE 7:e48084. doi: 10.1371/journal.pone.0048084.
    • (2012) PLoS ONE , vol.7
    • Schor, I.E.1    Lleres, D.2    Risso, G.J.3    Pawellek, A.4    Ule, J.5    Lamond, A.I.6
  • 78
    • 84883755139 scopus 로고    scopus 로고
    • Long non-coding RNAs: a new frontier in the study of human diseases
    • doi: 10.1016/j.canlet.2013.06.013
    • Shi, X., Sun, M., Liu, H., Yao, Y., and Song, Y. (2013). Long non-coding RNAs: a new frontier in the study of human diseases. Cancer Lett. 339, 159-166. doi: 10.1016/j.canlet.2013.06.013.
    • (2013) Cancer Lett. , vol.339 , pp. 159-166
    • Shi, X.1    Sun, M.2    Liu, H.3    Yao, Y.4    Song, Y.5
  • 79
    • 33845595633 scopus 로고    scopus 로고
    • Notch signaling enhances nestin expression in gliomas
    • doi: 10.1593/neo.06526
    • Shih, A. H., and Holland, E. C. (2006). Notch signaling enhances nestin expression in gliomas. Neoplasia 8, 1072-1082. doi: 10.1593/neo.06526.
    • (2006) Neoplasia , vol.8 , pp. 1072-1082
    • Shih, A.H.1    Holland, E.C.2
  • 80
    • 48949116262 scopus 로고    scopus 로고
    • miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    • doi: 10.1186/1741-7015-6-14
    • Silber, J., Lim, D. A., Petritsch, C., Persson, A. I., Maunakea, A. K., Yu, M., et al. (2008). miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 6:14. doi: 10.1186/1741-7015-6-14.
    • (2008) BMC Med. , vol.6 , pp. 14
    • Silber, J.1    Lim, D.A.2    Petritsch, C.3    Persson, A.I.4    Maunakea, A.K.5    Yu, M.6
  • 81
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • doi: 10.1038/nature03128
    • Singh, S. K., Hawkins, C., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., et al. (2004). Identification of human brain tumour initiating cells. Nature 432, 396-401. doi: 10.1038/nature03128.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3    Squire, J.A.4    Bayani, J.5    Hide, T.6
  • 82
    • 12944252955 scopus 로고    scopus 로고
    • PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer
    • doi: 10.1073/pnas.97.22.12216
    • Srikantan, V., Zou, Z., Petrovics, G., Xu, L., Augustus, M., Davis, L., et al. (2000). PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 97, 12216-12221. doi: 10.1073/pnas.97.22.12216.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 12216-12221
    • Srikantan, V.1    Zou, Z.2    Petrovics, G.3    Xu, L.4    Augustus, M.5    Davis, L.6
  • 83
    • 73649102464 scopus 로고    scopus 로고
    • EZH2 is essential for glioblastoma cancer stem cell maintenance
    • doi: 10.1158/0008-5472.CAN-09-1622
    • Suva, M. L., Riggi, N., Janiszewska, M., Radovanovic, I., Provero, P., Stehle, J. C., et al. (2009). EZH2 is essential for glioblastoma cancer stem cell maintenance. Cancer Res. 69, 9211-9218. doi: 10.1158/0008-5472.CAN-09-1622.
    • (2009) Cancer Res. , vol.69 , pp. 9211-9218
    • Suva, M.L.1    Riggi, N.2    Janiszewska, M.3    Radovanovic, I.4    Provero, P.5    Stehle, J.C.6
  • 84
    • 84879462680 scopus 로고    scopus 로고
    • Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer
    • doi: 10.1038/emboj.2013.99
    • Takayama, K. -I., Horie-Inoue, K., Katayama, S., Suzuki, T., Tsutsumi, S., Ikeda, K., et al. (2013). Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. EMBO J. 32, 1665-1680. doi: 10.1038/emboj.2013.99.
    • (2013) EMBO J. , vol.32 , pp. 1665-1680
    • Takayama, K.-I.1    Horie-Inoue, K.2    Katayama, S.3    Suzuki, T.4    Tsutsumi, S.5    Ikeda, K.6
  • 85
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • doi: 10.1038/nrclinonc.2010.196
    • Takebe, N., Harris, P. J., Warren, R. Q., and Ivy, S. P. (2011). Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat. Rev. Clin. Oncol. 8, 97-106. doi: 10.1038/nrclinonc.2010.196.
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 86
    • 79959251945 scopus 로고    scopus 로고
    • Essential role of the Hedgehog signaling pathway in human glioma-initiating cells
    • doi: 10.1111/j.1349-7006.2011.01943.x
    • Takezaki, T., Hide, T., Takanaga, H., Nakamura, H., Kuratsu, J., and Kondo, T. (2011). Essential role of the Hedgehog signaling pathway in human glioma-initiating cells. Cancer Sci. 102, 1306-1312. doi: 10.1111/j.1349-7006.2011.01943.x.
    • (2011) Cancer Sci. , vol.102 , pp. 1306-1312
    • Takezaki, T.1    Hide, T.2    Takanaga, H.3    Nakamura, H.4    Kuratsu, J.5    Kondo, T.6
  • 87
    • 78249258719 scopus 로고    scopus 로고
    • MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes
    • doi: 10.1016/j.febslet.2010.10.008
    • Tano, K., Mizuno, R., Okada, T., Rakwal, R., Shibato, J., Masuo, Y., et al. (2010). MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes. FEBS Lett. 584, 4575-4580. doi: 10.1016/j.febslet.2010.10.008.
    • (2010) FEBS Lett. , vol.584 , pp. 4575-4580
    • Tano, K.1    Mizuno, R.2    Okada, T.3    Rakwal, R.4    Shibato, J.5    Masuo, Y.6
  • 88
    • 77958472025 scopus 로고    scopus 로고
    • The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation
    • doi: 10.1016/j.cell.2010.09.049
    • Tian, D., Sun, S., and Lee, J. T. (2010). The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell 143, 390-403. doi: 10.1016/j.cell.2010.09.049.
    • (2010) Cell , vol.143 , pp. 390-403
    • Tian, D.1    Sun, S.2    Lee, J.T.3
  • 89
    • 77956927823 scopus 로고    scopus 로고
    • The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
    • doi: 10.1016/j.molcel.2010.08.011
    • Tripathi, V., Ellis, J. D., Shen, Z., Song, D. Y., Pan, Q., Watt, A. T., et al. (2010). The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol. Cell 39, 925-938. doi: 10.1016/j.molcel.2010.08.011.
    • (2010) Mol. Cell , vol.39 , pp. 925-938
    • Tripathi, V.1    Ellis, J.D.2    Shen, Z.3    Song, D.Y.4    Pan, Q.5    Watt, A.T.6
  • 90
  • 91
    • 79953748673 scopus 로고    scopus 로고
    • A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
    • doi: 10.1038/nature09819
    • Wang, K. C., Yang, Y. W., Liu, B., Sanyal, A., Corces-Zimmerman, R., Chen, Y., et al. (2011). A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature 472, 120-124. doi: 10.1038/nature09819.
    • (2011) Nature , vol.472 , pp. 120-124
    • Wang, K.C.1    Yang, Y.W.2    Liu, B.3    Sanyal, A.4    Corces-Zimmerman, R.5    Chen, Y.6
  • 92
    • 84859561616 scopus 로고    scopus 로고
    • Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation
    • doi: 10.1002/jcb.24055
    • Wang, P., Ren, Z., and Sun, P. (2012). Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. J. Cell. Biochem. 113, 1868-1874. doi: 10.1002/jcb.24055.
    • (2012) J. Cell. Biochem. , vol.113 , pp. 1868-1874
    • Wang, P.1    Ren, Z.2    Sun, P.3
  • 93
    • 79957840356 scopus 로고    scopus 로고
    • Long noncoding RNAs and human disease
    • doi: 10.1016/j.tcb.2011.04.001
    • Wapinski, O., and Chang, H. Y. (2011). Long noncoding RNAs and human disease. Trends Cell Biol. 21, 354-361. doi: 10.1016/j.tcb.2011.04.001.
    • (2011) Trends Cell Biol. , vol.21 , pp. 354-361
    • Wapinski, O.1    Chang, H.Y.2
  • 94
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • doi: 10.1056/NEJMra0708126
    • Wen, P. Y., and Kesari, S. (2008). Malignant gliomas in adults. N. Engl. J. Med. 359, 492-507. doi: 10.1056/NEJMra0708126.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 95
    • 50949090496 scopus 로고    scopus 로고
    • Poly A- transcripts expressed in HeLa cells
    • doi: 10.1371/journal.pone.0002803
    • Wu, Q., Kim, Y. C., Lu, J., Xuan, Z., Chen, J., Zheng, Y., et al. (2008). Poly A- transcripts expressed in HeLa cells. PLoS ONE 3:e2803. doi: 10.1371/journal.pone.0002803.
    • (2008) PLoS ONE , vol.3
    • Wu, Q.1    Kim, Y.C.2    Lu, J.3    Xuan, Z.4    Chen, J.5    Zheng, Y.6
  • 96
    • 84858992906 scopus 로고    scopus 로고
    • Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells
    • doi: 10.1074/jbc.M111.332627
    • Xia, H., Cheung, W. K., Ng, S. S., Jiang, X., Jiang, S., Sze, J., et al. (2012). Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells. J. Biol. Chem. 287, 9962-9971. doi: 10.1074/jbc.M111.332627.
    • (2012) J. Biol. Chem. , vol.287 , pp. 9962-9971
    • Xia, H.1    Cheung, W.K.2    Ng, S.S.3    Jiang, X.4    Jiang, S.5    Sze, J.6
  • 97
    • 79955836034 scopus 로고    scopus 로고
    • Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
    • doi: 10.1245/s10434-011-1581-y
    • Yang, Z., Zhou, L., Wu, L. M., Lai, M. C., Xie, H. Y., Zhang, F., et al. (2011). Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann. Surg. Oncol. 18, 1243-1250. doi: 10.1245/s10434-011-1581-y.
    • (2011) Ann. Surg. Oncol. , vol.18 , pp. 1243-1250
    • Yang, Z.1    Zhou, L.2    Wu, L.M.3    Lai, M.C.4    Xie, H.Y.5    Zhang, F.6
  • 98
    • 84872580192 scopus 로고    scopus 로고
    • Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype
    • doi: 10.1158/0008-5472.CAN-12-2895
    • Ying, Z., Li, Y., Wu, J., Zhu, X., Yang, Y., Tian, H., et al. (2013). Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res. 73, 990-999. doi: 10.1158/0008-5472.CAN-12-2895.
    • (2013) Cancer Res. , vol.73 , pp. 990-999
    • Ying, Z.1    Li, Y.2    Wu, J.3    Zhu, X.4    Yang, Y.5    Tian, H.6
  • 99
    • 67649442541 scopus 로고    scopus 로고
    • High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma
    • doi: 10.3892/ijo_00000219
    • Yu, M., Ohira, M., Li, Y., Niizuma, H., Oo, M. L., Zhu, Y., et al. (2009). High expression of ncRAN, a novel non-coding RNA mapped to chromosome 17q25.1, is associated with poor prognosis in neuroblastoma. Int. J. Oncol. 34, 931-938. doi: 10.3892/ijo_00000219.
    • (2009) Int. J. Oncol. , vol.34 , pp. 931-938
    • Yu, M.1    Ohira, M.2    Li, Y.3    Niizuma, H.4    Oo, M.L.5    Zhu, Y.6
  • 100
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • doi: 10.1038/nature06468
    • Yu, W., Gius, D., Onyango, P., Muldoon-Jacobs, K., Karp, J., Feinberg, A. P., et al. (2008). Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 451, 202-206. doi: 10.1038/nature06468.
    • (2008) Nature , vol.451 , pp. 202-206
    • Yu, W.1    Gius, D.2    Onyango, P.3    Muldoon-Jacobs, K.4    Karp, J.5    Feinberg, A.P.6
  • 101
    • 84878376400 scopus 로고    scopus 로고
    • Long non-coding RNA: a new player in cancer
    • doi: 10.1186/1756-8722-6-37
    • Zhang, H., Chen, Z., Wang, X., Huang, Z., He, Z., and Chen, Y. (2013). Long non-coding RNA: a new player in cancer. J. Hematol. Oncol. 6, 37. doi: 10.1186/1756-8722-6-37.
    • (2013) J. Hematol. Oncol. , vol.6 , pp. 37
    • Zhang, H.1    Chen, Z.2    Wang, X.3    Huang, Z.4    He, Z.5    Chen, Y.6
  • 102
    • 55349109963 scopus 로고    scopus 로고
    • Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
    • doi: 10.1126/science.1163045
    • Zhao, J., Sun, B. K., Erwin, J. A., Song, J. J., and Lee, J. T. (2008). Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science 322, 750-756. doi: 10.1126/science.1163045.
    • (2008) Science , vol.322 , pp. 750-756
    • Zhao, J.1    Sun, B.K.2    Erwin, J.A.3    Song, J.J.4    Lee, J.T.5
  • 103
    • 84861156701 scopus 로고    scopus 로고
    • MEG3 noncoding RNA: a tumor suppressor
    • doi: 10.1530/JME-12-18
    • Zhou, Y., Zhang, X., and Klibanski, A. (2012). MEG3 noncoding RNA: a tumor suppressor. J. Mol. Endocrinol. 48, R45-R53. doi: 10.1530/JME-12-18.
    • (2012) J. Mol. Endocrinol. , vol.48
    • Zhou, Y.1    Zhang, X.2    Klibanski, A.3
  • 104
    • 34548304069 scopus 로고    scopus 로고
    • Activation of p53 by MEG3 non-coding RNA
    • doi: 10.1074/jbc.M702029200
    • Zhou, Y., Zhong, Y., Wang, Y., Zhang, X., Batista, D. L., Gejman, R., et al. (2007). Activation of p53 by MEG3 non-coding RNA. J. Biol. Chem. 282, 24731-24742. doi: 10.1074/jbc.M702029200.
    • (2007) J. Biol. Chem. , vol.282 , pp. 24731-24742
    • Zhou, Y.1    Zhong, Y.2    Wang, Y.3    Zhang, X.4    Batista, D.L.5    Gejman, R.6
  • 105
    • 79551597724 scopus 로고    scopus 로고
    • ncRAN, a newly identified long noncoding RNA, enhances human bladder tumor growth, invasion, and survival
    • doi: 10.1016/j.urology.2010.09.022
    • Zhu, Y., Yu, M., Li, Z., Kong, C., Bi, J., Li, J., et al. (2011). ncRAN, a newly identified long noncoding RNA, enhances human bladder tumor growth, invasion, and survival. Urology 77, 510 e511-e515. doi: 10.1016/j.urology.2010.09.022.
    • (2011) Urology , vol.77 , Issue.510
    • Zhu, Y.1    Yu, M.2    Li, Z.3    Kong, C.4    Bi, J.5    Li, J.6


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