The implications of brain connectivity in the neuropsychology of autism

Neuropsychology Review

Volumn 24, Issue 1, 2014, Pages 16-31

  Maximo, Jose O ^a   Cadena, Elyse J ^a   Kana, Rajesh K ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Autism; Effective connectivity; fMRI; Functional connectivity; Underconnectivity; White matter integrity

Indexed keywords

AUTISM; BRAIN; BRAIN MAPPING; COGNITION; HUMAN; METHODOLOGY; NERVE TRACT; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; REST; REVIEW;

AUTISTIC DISORDER; BRAIN; BRAIN MAPPING; COGNITION; HUMANS; MAGNETIC RESONANCE IMAGING; NEURAL PATHWAYS; NEUROPSYCHOLOGY; REST;

EID: 84897619126     PISSN: 10407308     EISSN: 15736660     Source Type: Journal    
DOI: 10.1007/s11065-014-9250-0     Document Type: Review

References (167)

1. Abrahams, B. S.; Geschwind, D. H. (2008). Advances in autism genetics: on the threshold of a new neurobiology. Nature Reviews Genetics, 9, 341-355.
2. Abrams, D. A.; Lynch, C. J.; Cheng, K. M.; Phillips, J.; Supekar, K.; Ryali, S.; et al. (2013). Underconnectivity between voice-selective cortex and reward circuitry in children with autism. Proceedings of the National Academy of Sciences of the United States of America, 110, 12060-12065.
3. Agam, Y.; Joseph, R. M.; Barton, J. J.; Manoach, D. S. (2010). Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disorders. NeuroImage, 52, 336-347.
4. Alexander, A. L.; Lee, J. E.; Lazar, M.; Boudos, R.; DuBray, M. B.; Oakes, T. R.; et al. (2007). Diffusion tensor imaging of the corpus callosum in autism. NeuroImage, 34, 61-73.
5. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington: American Psychiatric Publishing.
6. Anagnostou, E.; Taylor, M. J. (2011). Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here. Molecular Autism, 2, 4.
7. Anderson, J. S.; Nielsen, J. A.; Froehlich, A. L.; DuBray, M. B.; Druzgal, T. J.; Cariello, A. N.; et al. (2011). Functional connectivity magnetic resonance imaging classification of autism. Brain: A Journal of Neurology, 134, 3742-3754.
8. Assaf, M.; Jagannathan, K.; Calhoun, V. D.; Miller, L.; Stevens, M. C.; Sahl, R.; et al. (2010). Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage, 53, 247-256.
9. Bailey, A.; Luthert, P.; Dean, A.; Harding, B.; Janota, I.; Montgomery, M.; et al. (1998). A clinicopathological study of autism. Brain: A Journal of Neurology, 121(Pt 5), 889-905.
10. Barnea-Goraly, N.; Kwon, H.; Menon, V.; Eliez, S.; Lotspeich, L.; Reiss, A. L. (2004). White matter structure in autism: preliminary evidence from diffusion tensor imaging. Biological Psychiatry, 55, 323-326.
11. Baruth, J. M.; Casanova, M. F.; El-Baz, A.; Horrell, T.; Mathai, G.; Sears, L.; et al. (2010). Low-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) modulates evoked-gamma frequency oscillations in Autism Spectrum Disorder (ASD). Journal of Neurotherapy, 14, 179-194.
12. Belmonte, M. K.; Allen, G.; Beckel-Mitchener, A.; Boulanger, L. M.; Carper, R. A.; Webb, S. J. (2004). Autism and abnormal development of brain connectivity. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 24, 9228-9231.
13. Ben Bashat, D.; Kronfeld-Duenias, V.; Zachor, D. A.; Ekstein, P. M.; Hendler, T.; Tarrasch, R.; et al. (2007). Accelerated maturation of white matter in young children with autism: a high b value DWI study. NeuroImage, 37, 40-47.
14. Bird, G.; Catmur, C.; Silani, G.; Frith, C.; Frith, U. (2006). Attention does not modulate neural responses to social stimuli in autism spectrum disorders. NeuroImage, 31, 1614-1624.
15. Biswal, B.; Yetkin, F. Z.; Haughton, V. M.; Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine/Society of Magnetic Resonance in Medicine, 34, 537-541.
16. Boly, M.; Perlbarg, V.; Marrelec, G.; Schabus, M.; Laureys, S.; Doyon, J.; et al. (2012). Hierarchical clustering of brain activity during human nonrapid eye movement sleep. Proceedings of the National Academy of Sciences of the United States of America, 109, 5856-5861.
17. Braeutigam, S.; Swithenby, S. J.; Bailey, A. J. (2008). Contextual integration the unusual way: a magnetoencephalographic study of responses to semantic violation in individuals with autism spectrum disorders. The European Journal of Neuroscience, 27, 1026-1036.
18. Brieber, S.; Herpertz-Dahlmann, B.; Fink, G. R.; Kamp-Becker, I.; Remschmidt, H.; Konrad, K. (2010). Coherent motion processing in autism spectrum disorder (ASD): an fMRI study. Neuropsychologia, 48, 1644-1651.
19. Buard, I.; Rogers, S. J.; Hepburn, S.; Kronberg, E.; Rojas, D. C. (2013). Altered oscillation patterns and connectivity during picture naming in autism. Frontiers in Human Neuroscience, 7, 742.
20. Buchel, C.; Friston, K. (2000). Assessing interactions among neuronal systems using functional neuroimaging. Neural Networks: the Official Journal of the International Neural Network Society, 13, 871-882.
21. Cardinale, R. C.; Shih, P.; Fishman, I.; Ford, L. M.; Muller, R. A. (2013). Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder. JAMA Psychiatry, 70(9), 975-982
22. Casanova, M. F.; Buxhoeveden, D. P.; Switala, A. E.; Roy, E. (2002). Minicolumnar pathology in autism. Neurology, 58, 428-432.
23. Centers for Control Disease. (2012). Prevalence of autism spectrum disorders: autism and developmental disabilities monitoring network, 14 sites, United States. MMWR Surveillance Summaries, 61, 12-19.
24. Cheng, Y.; Chou, K. H.; Chen, I. Y.; Fan, Y. T.; Decety, J.; Lin, C. P. (2010). Atypical development of white matter microstructure in adolescents with autism spectrum disorders. NeuroImage, 50, 873-882.
25. Cheon, K. A.; Kim, Y. S.; Oh, S. H.; Park, S. Y.; Yoon, H. W.; Herrington, J.; et al. (2011). Involvement of the anterior thalamic radiation in boys with high functioning autism spectrum disorders: a diffusion tensor imaging study. Brain Research, 1417, 77-86.
26. Cherkassky, V. L.; Kana, R. K.; Keller, T. A.; Just, M. A. (2006). Functional connectivity in a baseline resting-state network in autism. Neuroreport, 17, 1687-1690.
27. Cheung, C.; Chua, S. E.; Cheung, V.; Khong, P. L.; Tai, K. S.; Wong, T. K.; et al. (2009). White matter fractional anisotrophy differences and correlates of diagnostic symptoms in autism. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 50, 1102-1112.
28. Cordes, D.; Haughton, V. M.; Arfanakis, K.; Carew, J. D.; Turski, P. A.; Moritz, C. H.; et al. (2001). Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data. AJNR. American Journal of Neuroradiology, 22, 1326-1333.
29. Courchesne, E. (2002). Abnormal early brain development in autism. Molecular Psychiatry, 7(Suppl 2), S21-S23.
30. Courchesne, E.; Pierce, K. (2005). Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Current Opinion in Neurobiology, 15, 225-230.
31. Courchesne, E.; Karns, C. M.; Davis, H. R.; Ziccardi, R.; Carper, R. A.; Tigue, Z. D.; et al. (2001). Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology, 57, 245-254.
32. Courchesne, E.; Carper, R.; Akshoomoff, N. (2003). Evidence of brain overgrowth in the first year of life in autism. JAMA, the Journal of the American Medical Association, 290, 337-344.
33. Courchesne, E.; Mouton, P. R.; Calhoun, M. E.; Semendeferi, K.; Ahrens-Barbeau, C.; Hallet, M. J.; et al. (2011). Neuron number and size in prefrontal cortex of children with autism. JAMA, the Journal of the American Medical Association, 306, 2001-2010.
34. Dai, Z.; Yan, C.; Wang, Z.; Wang, J.; Xia, M.; Li, K.; et al. (2012). Discriminative analysis of early Alzheimer's disease using multi-modal imaging and multi-level characterization with multi-classifier (M3). NeuroImage, 59, 2187-2195.
35. Damarla, S. R.; Keller, T. A.; Kana, R. K.; Cherkassky, V. L.; Williams, D. L.; Minshew, N. J.; et al. (2010). Cortical underconnectivity coupled with preserved visuospatial cognition in autism: evidence from an fMRI study of an embedded figures task. Autism Research: Official Journal of the International Society for Autism Research, 3, 273-279.
36. Damasio, A. R.; Maurer, R. G. (1978). A neurological model for childhood autism. Archives of Neurology, 35, 777-786.
37. Delmonte, S.; Gallagher, L.; O'Hanlon, E.; McGrath, J.; Balsters, J. H. (2013). Functional and structural connectivity of frontostriatal circuitry in autism spectrum disorder. Frontiers in Human Neuroscience, 7, 430.
38. Deshpande, G.; Libero, L. E.; Sreenivasan, K. R.; Deshpande, H. D.; Kana, R. K. (2013). Identification of neural connectivity signatures of autism using machine learning. Frontiers in Human Neuroscience, 4, 670.
39. Di Martino, A.; Kelly, C.; Grzadzinski, R.; Zuo, X. N.; Mennes, M.; Mairena, M. A.; et al. (2011). Aberrant striatal functional connectivity in children with autism. Biological Psychiatry, 69, 847-856.
40. Di Martino, A.; Yan, C. G.; Li, Q.; Denio, E.; Castellanos, F. X.; Alaerts, K. et al. (2013). The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism. Molecular Psychiatry, 1-9.
41. Dichter, G. S.; Belger, A. (2008). Atypical modulation of cognitive control by arousal in autism. Psychiatry Research, 164, 185-197.
42. Dinstein, I.; Pierce, K.; Eyler, L.; Solso, S.; Malach, R.; Behrmann, M.; et al. (2011). Disrupted neural synchronization in toddlers with autism. Neuron, 70, 1218-1225.
43. Ebisch, S. J.; Gallese, V.; Willems, R. M.; Mantini, D.; Groen, W. B.; Romani, G. L.; et al. (2011). Altered intrinsic functional connectivity of anterior and posterior insula regions in high-functioning participants with autism spectrum disorder. Human Brain Mapping, 32, 1013-1028.
44. Fair, D. A.; Schlaggar, B. L.; Cohen, A. L.; Miezin, F. M.; Dosenbach, N. U.; Wenger, K. K.; et al. (2007). A method for using blocked and event-related fMRI data to study "resting state" functional connectivity. NeuroImage, 35, 396-405.
45. Fair, D. A.; Cohen, A. L.; Dosenbach, N. U.; Church, J. A.; Miezin, F. M.; Barch, D. M.; et al. (2008). The maturing architecture of the brain's default network. Proceedings of the National Academy of Sciences of the United States of America, 105, 4028-4032.
46. Farb, N. A.; Grady, C. L.; Strother, S.; Tang-Wai, D. F.; Masellis, M.; Black, S.; et al. (2013). Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation. Cortex; A Journal Devoted to the Study of the Nervous System and Behavior, 49, 1856-1873.
47. Feinberg, D. A.; Setsompop, K. (2013). Ultra-fast MRI of the human brain with simultaneous multi-slice imaging. Journal of Magnetic Resonance, 229, 90-100.
48. Fletcher, P. T.; Whitaker, R. T.; Tao, R.; DuBray, M. B.; Froehlich, A.; Ravichandran, C.; et al. (2010). Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism. NeuroImage, 51, 1117-1125.
49. Fox, M. D.; Raichle, M. E. (2007). Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nature Reviews Neuroscience, 8, 700-711.
50. Freitag, C. M. (2007). The genetics of autistic disorders and its clinical relevance: a review of the literature. Molecular Psychiatry, 12, 2-22.
51. Freitag, C. M.; Konrad, C.; Haberlen, M.; Kleser, C.; von Gontard, A.; Reith, W.; et al. (2008). Perception of biological motion in autism spectrum disorders. Neuropsychologia, 46, 1480-1494.
52. Fries, P. (2005). A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends in Cognitive Sciences, 9, 474-480.
53. Friston, K. J. (2011). Functional and effective connectivity: a review. Brain Connectivity, 1, 13-36.
54. Friston, K. J.; Frith, C. D.; Liddle, P. F.; Frackowiak, R. S. (1993). Functional connectivity: the principal-component analysis of large (PET) data sets. Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 13, 5-14.
55. Geschwind, D. H. (2008). Autism: many genes, common pathways? Cell, 135, 391-395.
56. Geschwind, D. H. (2011). Genetics of autism spectrum disorders. Trends in Cognitive Sciences, 15, 409-416.
57. Geschwind, D. H.; Levitt, P. (2007). Autism spectrum disorders: developmental disconnection syndromes. Current Opinion in Neurobiology, 17, 103-111.
58. Gillberg, C.; Wahlstrom, J. (1985). Chromosome abnormalities in infantile autism and other childhood psychoses: a population study of 66 cases. Developmental Medicine and Child Neurology, 27, 293-304.
59. Gotts, S. J.; Simmons, W. K.; Milbury, L. A.; Wallace, G. L.; Cox, R. W.; Martin, A. (2012). Fractionation of social brain circuits in autism spectrum disorders. Brain: a Journal of Neurology, 135, 2711-2725.
60. Greicius, M. D.; Supekar, K.; Menon, V.; Dougherty, R. F. (2009). Resting-state functional connectivity reflects structural connectivity in the default mode network. Cerebral Cortex, 19, 72-78.
61. Gusnard, D. A.; Akbudak, E.; Shulman, G. L.; Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98, 4259-4264.
62. Hagmann, P.; Sporns, O.; Madan, N.; Cammoun, L.; Pienaar, R.; Wedeen, V. J.; et al. (2010). White matter maturation reshapes structural connectivity in the late developing human brain. Proceedings of the National Academy of Sciences of the United States of America, 107, 19067-19072.
63. Happe, F.; Ronald, A.; Plomin, R. (2006). Time to give up on a single explanation for autism. Nature Neuroscience, 9, 1218-1220.
64. Hazlett, H. C.; Poe, M.; Gerig, G.; Smith, R. G.; Provenzale, J.; Ross, A.; et al. (2005). Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. Archives of General Psychiatry, 62, 1366-1376.
65. Herbert, M. R.; Ziegler, D. A.; Makris, N.; Filipek, P. A.; Kemper, T. L.; Normandin, J. J.; et al. (2004). Localization of white matter volume increase in autism and developmental language disorder. Annals of Neurology, 55, 530-540.
66. Horovitz, S. G.; Fukunaga, M.; de Zwart, J. A.; van Gelderen, P.; Fulton, S. C.; Balkin, T. J.; et al. (2008). Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study. Human Brain Mapping, 29, 671-682.
67. Horwitz, B.; Rumsey, J. M.; Grady, C. L.; Rapoport, S. I. (1988). The cerebral metabolic landscape in autism. Intercorrelations of regional glucose utilization. Archives of Neurology, 45, 749-755.
68. Jones, T. B.; Bandettini, P. A.; Kenworthy, L.; Case, L. K.; Milleville, S. C.; Martin, A.; et al. (2010). Sources of group differences in functional connectivity: an investigation applied to autism spectrum disorder. NeuroImage, 49, 401-414.
69. Just, M. A.; Cherkassky, V. L.; Keller, T. A.; Minshew, N. J. (2004). Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain: a Journal of Neurology, 127, 1811-1821.
70. Just, M. A.; Cherkassky, V. L.; Keller, T. A.; Kana, R. K.; Minshew, N. J. (2007). Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex, 17, 951-961.
71. Just, M. A.; Keller, T. A.; Malave, V. L.; Kana, R. K.; Varma, S. (2012). Autism as a neural systems disorder: a theory of frontal-posterior underconnectivity. Neuroscience and Biobehavioral Reviews, 36, 1292-1313.
72. Kana, R. K.; Keller, T. A.; Cherkassky, V. L.; Minshew, N. J.; Just, M. A. (2006). Sentence comprehension in autism: thinking in pictures with decreased functional connectivity. Brain: a Journal of Neurology, 129, 2484-2493.
73. Kana, R. K.; Keller, T. A.; Minshew, N. J.; Just, M. A. (2007). Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Biological Psychiatry, 62, 198-206.
74. Kana, R. K.; Keller, T. A.; Cherkassky, V. L.; Minshew, N. J.; Just, M. A. (2009). Atypical frontal-posterior synchronization of theory of mind regions in autism during mental state attribution. Social Neuroscience, 4, 135-152.
75. Kana, R. K.; Libero, L. E.; Moore, M. S. (2011). Disrupted cortical connectivity theory as an explanatory model for autism spectrum disorders. Physics of Life Reviews, 8, 410-437.
76. Kana, R. K.; Libero, L. E.; Hu, C. P.; Deshpande, H. D.; Colburn, J. S. (2012). Functional brain networks and white matter underlying theory-of-mind in autism. Social Cognitive and Affective Neuroscience, 9(1), 98-105.
77. Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217-250.
78. Ke, X.; Tang, T.; Hong, S.; Hang, Y.; Zou, B.; Li, H.; et al. (2009). White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging. Brain Research, 1265, 171-177.
79. Keehn, B.; Shih, P.; Brenner, L. A.; Townsend, J.; Muller, R. A. (2013). Functional connectivity for an "island of sparing" in autism spectrum disorder: an fMRI study of visual search. Human Brain Mapping, 34, 2524-2537.
80. Keller, T. A.; Kana, R. K.; Just, M. A. (2007). A developmental study of the structural integrity of white matter in autism. Neuroreport, 18, 23-27.
81. Kelly, A. M.; Di Martino, A.; Uddin, L. Q.; Shehzad, Z.; Gee, D. G.; Reiss, P. T.; et al. (2009). Development of anterior cingulate functional connectivity from late childhood to early adulthood. Cerebral Cortex, 19, 640-657.
82. Kennedy, D. P.; Courchesne, E. (2008). Functional abnormalities of the default network during self- and other-reflection in autism. Social Cognitive and Affective Neuroscience, 3, 177-190.
83. Kennedy, D. P.; Redcay, E.; Courchesne, E. (2006). Failing to deactivate: resting functional abnormalities in autism. Proceedings of the National Academy of Sciences of the United States of America, 103, 8275-8280.
84. Kleinhans, N. M.; Richards, T.; Sterling, L.; Stegbauer, K. C.; Mahurin, R.; Johnson, L. C.; et al. (2008). Abnormal functional connectivity in autism spectrum disorders during face processing. Brain: a Journal of Neurology, 131, 1000-1012.
85. Koshino, H.; Kana, R. K.; Keller, T. A.; Cherkassky, V. L.; Minshew, N. J.; Just, M. A. (2008). fMRI investigation of working memory for faces in autism: visual coding and underconnectivity with frontal areas. Cerebral Cortex, 18, 289-300.
86. Larson-Prior, L. J.; Zempel, J. M.; Nolan, T. S.; Prior, F. W.; Snyder, A. Z.; Raichle, M. E. (2009). Cortical network functional connectivity in the descent to sleep. Proceedings of the National Academy of Sciences of the United States of America, 106, 4489-4494.
87. Lee, J. E.; Bigler, E. D.; Alexander, A. L.; Lazar, M.; DuBray, M. B.; Chung, M. K.; et al. (2007). Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism. Neuroscience Letters, 424, 127-132.
88. Lee, P. S.; Yerys, B. E.; Della Rosa, A.; Foss-Feig, J.; Barnes, K. A.; James, J. D.; et al. (2009). Functional connectivity of the inferior frontal cortex changes with age in children with autism spectrum disorders: a fcMRI study of response inhibition. Cerebral Cortex, 19, 1787-1794.
89. Lenroot, R. K.; Giedd, J. N. (2006). Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neuroscience and Biobehavioral Reviews, 30, 718-729.
90. Liu, Y.; Cherkassky, V. L.; Minshew, N. J.; Just, M. A. (2011). Autonomy of lower-level perception from global processing in autism: evidence from brain activation and functional connectivity. Neuropsychologia, 49, 2105-2111.
91. Lombardo, M. V.; Chakrabarti, B.; Bullmore, E. T.; Sadek, S. A.; Pasco, G.; Wheelwright, S. J.; et al. (2010). Atypical neural self-representation in autism. Brain: a Journal of Neurology, 133, 611-624.
92. Losh, M.; Adolphs, R.; Poe, M. D.; Couture, S.; Penn, D.; Baranek, G. T.; et al. (2009). Neuropsychological profile of autism and the broad autism phenotype. Archives of General Psychiatry, 66, 518-526.
93. Lynch, C. J.; Uddin, L. Q.; Supekar, K.; Khouzam, A.; Phillips, J.; Menon, V. (2013). Default mode network in childhood autism: posteromedial cortex heterogeneity and relationship with social deficits. Biological Psychiatry, 74, 212-219.
94. Mason, R. A.; Williams, D. L.; Kana, R. K.; Minshew, N.; Just, M. A. (2008). Theory of mind disruption and recruitment of the right hemisphere during narrative comprehension in autism. Neuropsychologia, 46, 269-280.
95. Maximo, J. O.; Keown, C. L.; Nair, A.; Muller, R. A. (2013). Approaches to local connectivity in autism using resting state functional connectivity MRI. Frontiers in Human Neuroscience, 7, 605.
96. Minshew, N. J.; Keller, T. A. (2010). The nature of brain dysfunction in autism: functional brain imaging studies. Current Opinion in Neurology, 23, 124-130.
97. Mizuno, A.; Villalobos, M. E.; Davies, M. M.; Dahl, B. C.; Muller, R. A. (2006). Partially enhanced thalamocortical functional connectivity in autism. Brain Research, 1104, 160-174.
98. Monk, C. S.; Peltier, S. J.; Wiggins, J. L.; Weng, S. J.; Carrasco, M.; Risi, S.; et al. (2009). Abnormalities of intrinsic functional connectivity in autism spectrum disorders. NeuroImage, 47, 764-772.
99. Monk, C. S.; Weng, S. J.; Wiggins, J. L.; Kurapati, N.; Louro, H. M.; Carrasco, M.; et al. (2010). Neural circuitry of emotional face processing in autism spectrum disorders. Journal of Psychiatry & Neuroscience: JPN, 35, 105-114.
100. Mostofsky, S. H.; Powell, S. K.; Simmonds, D. J.; Goldberg, M. C.; Caffo, B.; Pekar, J. J. (2009). Decreased connectivity and cerebellar activity in autism during motor task performance. Brain: a Journal of Neurology, 132, 2413-2425.
101. Mottron, L.; Dawson, M.; Soulieres, I.; Hubert, B.; Burack, J. (2006). Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception. Journal of Autism and Developmental Disorders, 36, 27-43.
102. Mueller, S.; Keeser, D.; Samson, A. C.; Kirsch, V.; Blautzik, J.; Grothe, M.; et al. (2013). Convergent findings of altered functional and structural brain connectivity in individuals with high functioning autism: a multimodal MRI study. PloS One, 8, e67329.
103. Müller, R. A. (2007). The study of autism as a distributed disorder. Mental Retardation and Developmental Disabilities Research Reviews, 13, 85-95.
104. Muller, R. A.; Pierce, K.; Ambrose, J. B.; Allen, G.; Courchesne, E. (2001). Atypical patterns of cerebral motor activation in autism: a functional magnetic resonance study. Biological Psychiatry, 49, 665-676.
105. Muller, R. A.; Shih, P.; Keehn, B.; Deyoe, J. R.; Leyden, K. M.; Shukla, D. K. (2011). Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders. Cerebral Cortex, 21, 2233-2243.
106. Murdaugh, D. L.; Shinkareva, S. V.; Deshpande, H. R.; Wang, J.; Pennick, M. R.; Kana, R. K. (2012). Differential deactivation during mentalizing and classification of autism based on default mode network connectivity. PloS One, 7, e50064.
107. Murias, M.; Webb, S. J.; Greenson, J.; Dawson, G. (2007). Resting state cortical connectivity reflected in EEG coherence in individuals with autism. Biological Psychiatry, 62, 270-273.
108. Murphy, E. R.; Foss-Feig, J.; Kenworthy, L.; Gaillard, W. D.; Vaidya, C. J. (2012). Atypical functional connectivity of the amygdala in childhood autism spectrum disorders during spontaneous attention to eye-gaze. Autism Research and Treatment, 2012, 652408.
109. Nair, A.; Treiber, J. M.; Shukla, D. K.; Shih, P.; Muller, R. A. (2013). Impaired thalamocortical connectivity in autism spectrum disorder: a study of functional and anatomical connectivity. Brain: a Journal of Neurology, 136, 1942-1955.
110. Newman, S. D.; Carpenter, P. A.; Varma, S.; Just, M. A. (2003). Frontal and parietal participation in problem solving in the tower of London: fMRI and computational modeling of planning and high-level perception. Neuropsychologia, 41, 1668-1682.
111. Nielsen, J. A.; Zielinski, B. A.; Fletcher, P. T.; Alexander, A. L.; Lange, N.; Bigler, E. D.; et al. (2013). Multisite functional connectivity MRI classification of autism: ABIDE results. Frontiers in Human Neuroscience, 7, 599.
112. Noonan, S. K.; Haist, F.; Muller, R. A. (2009). Aberrant functional connectivity in autism: evidence from low-frequency BOLD signal fluctuations. Brain Research, 1262, 48-63.
113. Paakki, J. J.; Rahko, J.; Long, X.; Moilanen, I.; Tervonen, O.; Nikkinen, J.; et al. (2010). Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders. Brain Research, 1321, 169-179.
114. Perez Velazquez, J. L.; Barcelo, F.; Hung, Y.; Leshchenko, Y.; Nenadovic, V.; Belkas, J.; et al. (2009). Decreased brain coordinated activity in autism spectrum disorders during executive tasks: reduced long-range synchronization in the fronto-parietal networks. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 73, 341-349.
115. Pierce, K.; Muller, R. A.; Ambrose, J.; Allen, G.; Courchesne, E. (2001). Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI. Brain: a Journal of Neurology, 124, 2059-2073.
116. Pineda, J. A.; Juavinett, A.; Datko, M. (2012). Self-regulation of brain oscillations as a treatment for aberrant brain connections in children with autism. Medical Hypotheses, 79, 790-798.
117. Raichle, M. E.; MacLeod, A. M.; Snyder, A. Z.; Powers, W. J.; Gusnard, D. A.; Shulman, G. L. (2001). A default mode of brain function. Proceedings of the National Academy of Sciences of the United States of America, 98, 676-682.
118. Redcay, E.; Moran, J. M.; Mavros, P. L.; Tager-Flusberg, H.; Gabrieli, J. D.; Whitfield-Gabrieli, S. (2013). Intrinsic functional network organization in high-functioning adolescents with autism spectrum disorder. Frontiers in Human Neuroscience, 7, 573.
119. Rimland, B. (1964). Infantile autism: The syndrome and its implications for a neural theory of behavior. New York: Appleton-Century-Crofts.
120. Rubenstein, J. L.; Merzenich, M. M. (2003). Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes, Brain and Behavior, 2, 255-267.
121. Rudie, J. D.; Hernandez, L. M.; Brown, J. A.; Beck-Pancer, D.; Colich, N. L.; Gorrindo, P.; et al. (2012a). Autism-associated promoter variant in MET impacts functional and structural brain networks. Neuron, 75, 904-915.
122. Rudie, J. D.; Shehzad, Z.; Hernandez, L. M.; Colich, N. L.; Bookheimer, S. Y.; Iacoboni, M.; et al. (2012b). Reduced functional integration and segregation of distributed neural systems underlying social and emotional information processing in autism spectrum disorders. Cerebral Cortex, 22, 1025-1037.
123. Rudie, J. D.; Brown, J. A.; Beck-Pancer, D.; Hernandez, L. M.; Dennis, E. L.; Thompson, P. M.; et al. (2013). Altered functional and structural brain network organization in autism. Neuroimage Clinical, 2, 79-94.
124. Sahyoun, C. P.; Belliveau, J. W.; Soulieres, I.; Schwartz, S.; Mody, M. (2010). Neuroimaging of the functional and structural networks underlying visuospatial vs. linguistic reasoning in high-functioning autism. Neuropsychologia, 48, 86-95.
125. Satterthwaite, T. D.; Elliott, M. A.; Gerraty, R. T.; Ruparel, K.; Loughead, J.; Calkins, M. E.; et al. (2013). An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data. NeuroImage, 64, 240-256.
126. Schipul, S. E.; Keller, T. A.; Just, M. A. (2011). Inter-regional brain communication and its disturbance in autism. Frontiers in Systems Neuroscience, 5, 10.
127. Schipul, S. E.; Williams, D. L.; Keller, T. A.; Minshew, N. J.; Just, M. A. (2012). Distinctive neural processes during learning in autism. Cerebral Cortex, 22, 937-950.
128. Sepulcre, J.; Liu, H.; Talukdar, T.; Martincorena, I.; Yeo, B. T.; Buckner, R. L. (2010). The organization of local and distant functional connectivity in the human brain. PLoS Computational Biology, 6, e1000808.
129. Shen, M. D.; Shih, P.; Ottl, B.; Keehn, B.; Leyden, K. M.; Gaffrey, M. S.; et al. (2012). Atypical lexicosemantic function of extrastriate cortex in autism spectrum disorder: evidence from functional and effective connectivity. NeuroImage, 62, 1780-1791.
130. Shih, P.; Shen, M.; Ottl, B.; Keehn, B.; Gaffrey, M. S.; Muller, R. A. (2010). Atypical network connectivity for imitation in autism spectrum disorder. Neuropsychologia, 48, 2931-2939.
131. Shih, P.; Keehn, B.; Oram, J. K.; Leyden, K. M.; Keown, C. L.; Muller, R. A. (2011). Functional differentiation of posterior superior temporal sulcus in autism: a functional connectivity magnetic resonance imaging study. Biological Psychiatry, 70, 270-277.
132. Shukla, D. K.; Keehn, B.; Muller, R. A. (2010). Regional homogeneity of fMRI time series in autism spectrum disorders. Neuroscience Letters, 476, 46-51.
133. Shukla, D. K.; Keehn, B.; Muller, R. A. (2011). Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 52, 286-295.
134. Silk, T. J.; Rinehart, N.; Bradshaw, J. L.; Tonge, B.; Egan, G.; O'Boyle, M. W.; et al. (2006). Visuospatial processing and the function of prefrontal-parietal networks in autism spectrum disorders: a functional MRI study. The American Journal of Psychiatry, 163, 1440-1443.
135. Sokhadze, E. M.; El-Baz, A.; Baruth, J.; Mathai, G.; Sears, L.; Casanova, M. F. (2009). Effects of low frequency repetitive transcranial magnetic stimulation (rTMS) on gamma frequency oscillations and event-related potentials during processing of illusory figures in autism. Journal of Autism and Developmental Disorders, 39, 619-634.
136. Solomon, M.; Ozonoff, S. J.; Ursu, S.; Ravizza, S.; Cummings, N.; Ly, S.; et al. (2009). The neural substrates of cognitive control deficits in autism spectrum disorders. Neuropsychologia, 47, 2515-2526.
137. Sparks, B. F.; Friedman, S. D.; Shaw, D. W.; Aylward, E. H.; Echelard, D.; Artru, A. A.; et al. (2002). Brain structural abnormalities in young children with autism spectrum disorder. Neurology, 59, 184-192.
138. Sporns, O. (2013). Network attributes for segregation and integration in the human brain. Current Opinion in Neurobiology, 23, 162-171.
139. Sporns, O.; Tononi, G.; Edelman, G. M. (2000). Connectivity and complexity: the relationship between neuroanatomy and brain dynamics. Neural Networks: the Official Journal of the International Neural Network Society, 13, 909-922.
140. Sundaram, S. K.; Kumar, A.; Makki, M. I.; Behen, M. E.; Chugani, H. T.; Chugani, D. C. (2008). Diffusion tensor imaging of frontal lobe in autism spectrum disorder. Cerebral Cortex, 18, 2659-2665.
141. Supekar, K.; Uddin, L. Q.; Prater, K.; Amin, H.; Greicius, M. D.; Menon, V. (2010). Development of functional and structural connectivity within the default mode network in young children. NeuroImage, 52, 290-301.
142. Tononi, G.; Edelman, G. M.; Sporns, O. (1998). Complexity and coherency: integrating information in the brain. Trends in Cognitive Sciences, 2, 474-484.
143. Turner, K. C.; Frost, L.; Linsenbardt, D.; McIlroy, J. R.; Muller, R. A. (2006). Atypically diffuse functional connectivity between caudate nuclei and cerebral cortex in autism. Behavioral and Brain Functions: BBF, 2, 34.
144. Tyszka, J. M.; Kennedy, D. P.; Paul, L. K.; Adolphs, R. (2013). Largely Typical patterns of resting-state functional connectivity in high-functioning adults with autism. Cerebral Cortex.
145. Uddin, L. Q.; Supekar, K. S.; Ryali, S.; Menon, V. (2011). Dynamic reconfiguration of structural and functional connectivity across core neurocognitive brain networks with development. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 31, 18578-18589.
146. Uddin, L. Q.; Supekar, K.; Lynch, C. J.; Khouzam, A.; Phillips, J.; Feinstein, C.; et al. (2013a). Salience network-based classification and prediction of symptom severity in children with autism. JAMA Psychiatry, 70, 869-879.
147. Uddin, L. Q.; Supekar, K.; Menon, V. (2013b). Reconceptualizing functional brain connectivity in autism from a developmental perspective. Frontiers in Human Neuroscience, 7, 458.
148. Van Dijk, K. R.; Sabuncu, M. R.; Buckner, R. L. (2012). The influence of head motion on intrinsic functional connectivity MRI. NeuroImage, 59, 431-438.
149. Vargas, D. L.; Nascimbene, C.; Krishnan, C.; Zimmerman, A. W.; Pardo, C. A. (2005). Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals of Neurology, 57, 67-81.
150. Villalobos, M. E.; Mizuno, A.; Dahl, B. C.; Kemmotsu, N.; Muller, R. A. (2005). Reduced functional connectivity between V1 and inferior frontal cortex associated with visuomotor performance in autism. NeuroImage, 25, 916-925.
151. Vissers, M. E.; Cohen, M. X.; Geurts, H. M. (2012). Brain connectivity and high functioning autism: a promising path of research that needs refined models, methodological convergence, and stronger behavioral links. Neuroscience and Biobehavioral Reviews, 36, 604-625.
152. von dem Hagen, E. A.; Stoyanova, R. S.; Baron-Cohen, S.; Calder, A. J. (2013). Reduced functional connectivity within and between 'social' resting state networks in autism spectrum conditions. Social Cognitive and Affective Neuroscience, 8, 694-701.
153. Wahlstrom, J.; Gillberg, C.; Gustavson, K. H.; Holmgren, G. (1986). Infantile autism and the fragile X. A Swedish multicenter study. American Journal of Medical Genetics, 23, 403-408.
154. Waiter, G. D.; Williams, J. H.; Murray, A. D.; Gilchrist, A.; Perrett, D. I.; Whiten, A. (2005). Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: a voxel-based investigation. NeuroImage, 24, 455-461.
155. Wang, J.; Zuo, X.; He, Y. (2010). Graph-based network analysis of resting-state functional MRI. Frontiers in Systems Neuroscience, 4, 16.
156. Washington, S. D.; Gordon, E. M.; Brar, J.; Warburton, S.; Sawyer, A. T.; Wolfe, A. et al. (2013). Dysmaturation of the default mode network in autism. Human Brain Mapping. doi: 10.1002/hbm.22252.
157. Weaver, K. E.; Chaovalitwongse, W. A.; Novotny, E. J.; Poliakov, A.; Grabowski, T. G.; Ojemann, J. G. (2013). Local functional connectivity as a pre-surgical tool for seizure focus identification in non-lesion, focal epilepsy. Frontiers in Neurology, 4, 43.
158. Weinstein, M.; Ben-Sira, L.; Levy, Y.; Zachor, D. A.; Ben Itzhak, E.; Artzi, M.; et al. (2011). Abnormal white matter integrity in young children with autism. Human Brain Mapping, 32, 534-543.
159. Welchew, D. E.; Ashwin, C.; Berkouk, K.; Salvador, R.; Suckling, J.; Baron-Cohen, S.; et al. (2005). Functional disconnectivity of the medial temporal lobe in Asperger's syndrome. Biological Psychiatry, 57, 991-998.
160. Weng, S. J.; Wiggins, J. L.; Peltier, S. J.; Carrasco, M.; Risi, S.; Lord, C.; et al. (2010). Alterations of resting state functional connectivity in the default network in adolescents with autism spectrum disorders. Brain Research, 1313, 202-214.
161. Wicker, B.; Fonlupt, P.; Hubert, B.; Tardif, C.; Gepner, B.; Deruelle, C. (2008). Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder. Social Cognitive and Affective Neuroscience, 3, 135-143.
162. Wiggins, J. L.; Peltier, S. J.; Ashinoff, S.; Weng, S. J.; Carrasco, M.; Welsh, R. C.; et al. (2011). Using a self-organizing map algorithm to detect age-related changes in functional connectivity during rest in autism spectrum disorders. Brain Research, 1380, 187-197.
163. Wolff, J. J.; Gu, H.; Gerig, G.; Elison, J. T.; Styner, M.; Gouttard, S.; et al. (2012). Differences in white matter fiber tract development present from 6 to 24 months in infants with autism. The American Journal of Psychiatry, 169, 589-600.
164. Yin, Y.; Jin, C.; Eyler, L. T.; Jin, H.; Hu, X.; Duan, L.; et al. (2012). Altered regional homogeneity in post-traumatic stress disorder: a resting-state functional magnetic resonance imaging study. Neuroscience Bulletin, 28, 541-549.
165. You, X.; Norr, M.; Murphy, E.; Kuschner, E. S.; Bal, E.; Gaillard, W. D.; et al. (2013). Atypical modulation of distant functional connectivity by cognitive state in children with autism spectrum disorders. Frontiers in Human Neuroscience, 7, 482.
166. Zalesky, A.; Fornito, A.; Egan, G. F.; Pantelis, C.; Bullmore, E. T. (2012). The relationship between regional and inter-regional functional connectivity deficits in schizophrenia. Human Brain Mapping, 33, 2535-2549.
167. Zang, Y.; Jiang, T.; Lu, Y.; He, Y.; Tian, L. (2004). Regional homogeneity approach to fMRI data analysis. NeuroImage, 22, 394-400.