Functional and anatomical cortical underconnectivity in autism: Evidence from an fmri study of an executive function task and corpus callosum morphometry

Cerebral Cortex

Volumn 17, Issue 4, 2007, Pages 951-961

  Just, Marcel Adam ^a   Cherkassky, Vladimir L ^a   Keller, Timothy A ^a   Kana, Rajesh K ^a   Minshew, Nancy J ^a,b  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Autism; Corpus callosum; Executive function; fMRI; Functional connectivity

Indexed keywords

ADULT; ARTICLE; AUTISM; BRAIN CORTEX; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CLINICAL ARTICLE; COGNITION; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CORPUS CALLOSUM; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENDER; GROUPS BY AGE; HUMAN; INFORMATION PROCESSING; INTELLIGENCE QUOTIENT; MALE; MORPHOMETRICS; NEUROANATOMY; NEUROIMAGING; PARIETAL LOBE; PRIORITY JOURNAL; TASK PERFORMANCE;

ADULT; AUTISTIC DISORDER; BRAIN MAPPING; CEREBRAL CORTEX; COGNITION; CORPUS CALLOSUM; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NEURAL PATHWAYS;

EID: 33846923678     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhl006     Document Type: Article

References (60)

1. Barnea-Goraly N, Kwon H, Menon V, Eliez S, Lotspeich L, Reiss AL. 2004. White matter structure in autism: preliminary evidence from diffusion tensor imaging. Biol Psychiatry 55:323-326.
2. Baron-Cohen S, Leslie AM, Frith U. 1985. Does the autistic child have a "theory of mind"? Cognition 21:37-46.
3. Bennetto L, Pennington BF, Rogers SJ. 1996. Intact and impaired memory functions in autism. Child Dev 67:1816-1835.
4. Carper RA, Moses P, Tigue ZD, Courchesne E. 2002. Cerebral lobes in autism: early hyperplasia and abnormal age effects. Neuroimage 16:1038-1051.
5. Casanova MF, Buxhoeveden DP, Switala AE, Roy E. 2002. Minicolumnar pathology in autism. Neurology 58:428-432.
6. Castelli F, Frith C, Happe F, Frith U. 2002. Autism, Asperger Syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 125:1839-1849.
7. Chung MK, Dalton KM, Alexander AL, Davisdon RJ. 2004. Less white matter concentration in autism: a 2D voxel-based morphometry. Neuroimage 23:242-251.
8. Cohen J, Cohen P. 1983. Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates.
9. Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, Chisum HJ, Moses P, Pierce K, Lord C, Lincoln AJ, Pizzo S, Schrebman L, Haas RH, Akshoomoff NA, Courchesne RY. 2001. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 57:245-254.
10. Critchley HD, Daly EM, Bullmore ET, Williams STR, Amelsvoort TV, Robertson DM, Rowe A, Phillips M, McAlonan G, Howlin P, Murphy DGM. 2000. The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain 123:2203-2212.
11. Egaas B, Courchesne E, Saitoh O. 1995. Reduced size of the corpus callosum in autism. Arch Neurol 52:794-801.
12. Fisher RA. 1921. On the probable error of a coefficient of correlation deduced from a small sample. Metron 1:3-32.
13. Friston K, Ashburner J, Frith C, Poline J-B, Heather J, Frackowiak R. 1995. Spatial registration and normalization of images. Hum Brain Map 2:165-189.
14. Friston KJ. 1994. Functional and effective connectivity in neuroimaging: a synthesis. Hum Brain Map 2:56-78.
15. Frith U. 1989. Autism: explaining the enigma. Oxford, UK: Blackwell.
16. Hardan AY, Minshew NJ, Keshavan MS. 2000. Corpus callosum size in autism. Neurology 55:1033-1036.
17. Harris GJ, Chabris CF, Clark J, Urban T, Aharon I, Steele S, McGrath L, Condouris K, Tager-Flusberg H. 2006. Brain activation during semantic processing in autism spectrum disorders via functional magnetic resonance imaging. Brain and Cognition 61:54-68.
18. Herbert MR, Harris GJ, Adrien KT, Ziegler DA, Makris N, Kennedy DN, Lange NT, Chabris CF, Bakardjiev A, Hodgson J, Takeoka M, Tager-Flusberg H, Caviness VS Jr. 2002. Abnormal asymmetry in language association cortex in autism. Ann Neurol 52:588-596.
19. Herbert MR, Zeigler DA, Deutsch CK, O'Brien LM, Lange N., Bakardjiev A, Hodgson J, Adrien KT, Steele S, Makris N, Kennedy D, Harris GJ, Caviness VS Jr. 2003. Dissociation of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 126:1182-1192.
20. Herbert MR, Zeigler EA, Makris N, Filipek PA, Kemper TL, Normandin JJ, Sanders HA, Kennedy DN, Caviness VS Jr. 2004. Localization of white matter volume increase in autism and developmental language disorder. Ann Neurol 55:530-540.
21. Hill EL, Frith U. 2003. Understanding autism: insights from mind and brain. Philos Trans R Soc Lond Biol Sci 358:281-289.
22. Hollingshead AB. 1957. Two-factor index of social position. New Haven, CT: Yale University, Department of Sociology.
23. Horwitz B, Rumsey JM, Donohue BC. 1998. Functional connectivity of the angular gyrus in normal reading and dyslexia. Proc Natl Acad Sci USA 95:8939-8944.
24. Horwitz B, Rumsey JM, Grady CL, Rapoport SI. 1988. The cerebral metabolic landscape in autism: intercorrelations of regional glucose utilization. Arch Neurol 45:749-755.
25. Hughes C, Russell J. 1993. Autistic children's difficulty with mental disengagement from an object: its implications for theories of autism. Dev Psychol 29:498-510.
26. Hughes C, Russell J, Robbins TW. 1994. Evidence for executive dysfunction in autism. Neuropsychologia 32:477-492.
27. Innocenti GM. 1986. General organization of callosal connections. In: Jones EG, Peters A, editors. Cerebral Cortex. New York: Plenum. p 291-354.
28. Just MA, Cherkassky VL, Keller TA, Minshew NJ. 2004. Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain 127:1811-1821.
29. Koshino H, Carpenter PA, Minshew NJ, Cherkassky V, Keller TA, Just MA. 2005. Functional connectivity in an fMRI working memory task in high functioning autism. Neuroimage 24:810-821.
30. Lawrie SM, Buechel C, Whalley HC, Frith CD, Friston KJ, Johnstone EC. 2002. Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 51:1008-1011.
31. Lord C, Risi S, Lambrecht L, Cook EH Jr, Leventhal BL, DiLavore PC, Pickles A, Rutter M. 2000. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 30:205-223.
32. Lord C, Rutter M, LeCouteur A. 1994. Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24:659-685.
33. Luna B, Minshew NJ, Garver KE, Lazar NA, Thulborn KR, Eddy WF, Sweeney JA. 2002. Neocortical system abnormalities in autism. Neurology 59:834-840.
34. Manes F, Piven J, Vrancic D, Nanclares V, Plebst C, Starkstein SE. 1999. An MRI study of the corpus callosum and cerebellum in mentally retarded autistic individuals. J Neuropsychiatry Clin Neurosci 11:470-474.
35. McLaughlin T, Steinberg B, Christensen B, Law I, Parving A, Friberg L. 1992. Potential language and attentional networks revealed through factor analysis of rCBF data measured with SPECT. J Cereb Blood Flow Metab 12:535-545.
36. Mesulam M-M. 1990. Large-scale neurocognitive networks and distributed processing for attention, language and memory. Ann Neurol 28:597-613.
37. Mesulam M-M. 1998. From sensation to cognition. Brain 121:1013-1052.
38. Minshew NJ, Goldstein G. 1998. Autism as a disorder of complex information processing. Ment Retard Dev Disabil Res Rev 4:129-136.
39. Minshew NJ, Goldstein G, Siegel D. 1997. Neuropsychologic functioning in autism: profile of a complex information processing disorder. J Int Neuropsychol Soc 3:303-316.
40. Minshew NJ, Meyer J, Goldstein G. 2002. Abstract reasoning in autism: a dissociation between concept formation and concept identification. Neuropsychology 16:327-334.
41. Minshew NJ, Sung K, Jones BL, Furman JM. 2004. Underdevelopment of the postural control system in autism. Neurology 63:2056-2061.
42. Mottron L, Burack JA. 2001. Enhanced perceptual functioning in the development of autism. In: Burack JA, Charman T, Yirmiya N, Zelazo P, editors. The development of autism: perspectives from theory and research. Mahwah, NJ: Erlbaum. p 131-148.
43. Mottron L, Burack J, Iarocci G, Belleville S, Enns J. 2003. Locally oriented perception with intact global processing among adolescents with high-functioning autism: evidence from multiple paradigms. J Child Psychol Psychiatry 44:904-913.
44. Newman SD, Carpenter PA, Varma S, Just MA. 2003. Frontal and parietal participation in problem solving in the Tower of London: fMRI and computational modeling of planning and high-level perception. Neuropsychologia 41:1668-1682.
45. Ozonoff S, Jensen J. 1999. Specific executive function profiles in three neurodevelopmental disord ers. J Autism Dev Disord 29:171-177.
46. Ozonoff S, McEvoy RE. 1994. A longitudinal study of executive function and theory of mind: development in autism. Dev Psychopathol 6:415-431.
47. Ozonoff S, Pennington BF, Rogers SJ. 1991. Executive function deficits in high-functioning autistic individuals: relationship to theory of mind. J Child Psychol Psychiatry 32:1081-1105.
48. Pandya DN, Seltzer B. 1986. The topography of commissioned fibers. In: Lepore F, Ptito M, Jasper HH, editors. Two hemispheres - one brain: functions of the corpus callosum. New York: Liss. p 47-73.
49. Peterson BS, Skudlarski P, Gatenby JC, Zhang H, Anderson AW, Gore JC. 1999. An fMRI study of Stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Soc Biol Psychiatry 45:1237-1258.
50. Pierce K, Muller R-A, Ambrose J, Allen G, Courchesne E. 2001. Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI. Brain 124:2059-2073.
51. Piven J, Bailey J, Ranson BJ, Arndt S. 1997. An MRI study of the corpus callosum in autism. Am J Psychiatry 154:1051-1056.
52. Quigley M, Cordes D, Wendt G, Turski P, Moritz C, Haughton V, Meyerand ME. 2001. Effect of focal and nonfocal cerebral lesions on functional connectivity studied with MR imaging. Am J Neuroradiol 22:294-300.
53. Saitoh O, Courchesne E, Egaas B, Lincoln AJ, Schreibman L. 1995. Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities. Neurology 45:317-324.
54. Schneider W. 1999. Working memory in a multi-level hybrid connnectionist control architectue (CAPS). In: Miyake A, Shah P, editors. Models of working memory: mechanisms of active maintenance and executive control. Cambridge, MA: Cambridge University Press. p 340-374.
55. Schultz RT, Gauthier I, Klin A, Fulbright RK, Anderson AW, Volkmar F, Skudlarski P, Lacadie C, Cohen DJ, Gore JC. 2000. Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Arch Gen Psychiatry 57:331-340.
56. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M. 2002. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15:273-289.
57. Vidal CN, DeVito TJ, Hayashi KM, Drost DJ, Williamson PC, Craven-Thuss B, Herman D, Sui Y, Toga AW, Nicolson R, Thompson PM. 2003. Detection and visualization of corpus callosum deficits in autistic children using novel anatomical mapping algorithms. Proceedings of the Human Brain Mapping Conference; 2003 June; New York.
58. Wechsler D. 1999. Wechsler Abbreviated Scales of Intelligence (WASI). San Antonio, TX: Psychological Corporation.
59. Witelson SF. 1989. Hand and sex differences in the isthmus and genu of the human corpus callosum: a postmortem morphological study. Brain 112:799-835.
60. Zilbovicius M, Garreau B, Samson V, Remy P, Barthelemy P, Syrota A, Lelord G. 1995. Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry 152:248-252.