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Volumn 15, Issue 2, 2005, Pages 225-230

Why the frontal cortex in autism might be talking only to itself: Local over-connectivity but long-distance disconnection

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; AUTISM; BRAIN FUNCTION; CELL ACTIVATION; CELL MIGRATION; COGNITION; DISEASE SEVERITY; EMOTION; FRONTAL CORTEX; GLIA CELL; HUMAN; INFLAMMATION; NERVE CELL NETWORK; NERVOUS SYSTEM DEVELOPMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SOCIAL BEHAVIOR; FRONTAL LOBE; PATHOLOGY;

EID: 20544457861     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2005.03.001     Document Type: Review
Times cited : (752)

References (50)
  • 1
    • 0018166008 scopus 로고
    • A neurological model for childhood autism
    • Damasio AR, Maurer RG: A neurological model for childhood autism. Arch Neural 1978, 35:777-786.
    • (1978) Arch Neural , vol.35 , pp. 777-786
    • Damasio, A.R.1    Maurer, R.G.2
  • 3
    • 0042324648 scopus 로고    scopus 로고
    • Annotation: The neural basis of social impairments in autism: The role of the dorsal medial-frontal cortex and anterior cingulate system
    • Mundy P: Annotation: the neural basis of social impairments in autism: the role of the dorsal medial-frontal cortex and anterior cingulate system. J Child Psychol Psychiatry 2003, 44:793-809. The author provides a thorough review of the dorsal medial frontal cortex and anterior cingulate cortex and their role in the pathology of autism.
    • (2003) J Child Psychol Psychiatry , vol.44 , pp. 793-809
    • Mundy, P.1
  • 5
    • 0000984981 scopus 로고
    • Autistic disturbances of affective contact
    • Kanner L: Autistic disturbances of affective contact. Nervous Child 1943, 2:217-250.
    • (1943) Nervous Child , vol.2 , pp. 217-250
    • Kanner, L.1
  • 6
    • 0025736784 scopus 로고
    • The development of a theory of mind in autism: Deviance and delay?
    • Baron-Cohen S: The development of a theory of mind in autism: deviance and delay? Psychiatr Clin North Am 1991, 14:33-51.
    • (1991) Psychiatr Clin North Am , vol.14 , pp. 33-51
    • Baron-Cohen, S.1
  • 7
    • 0026316724 scopus 로고
    • Executive function deficits in high-functioning autistic individuals: Relationship to theory of mind
    • Ozonoff S, Pennington BF, Rogers SJ: Executive function deficits in high-functioning autistic individuals: relationship to theory of mind. J Child Psychol Psychiatry 1991, 32:1081-1105.
    • (1991) J Child Psychol Psychiatry , vol.32 , pp. 1081-1105
    • Ozonoff, S.1    Pennington, B.F.2    Rogers, S.J.3
  • 8
    • 0025251913 scopus 로고
    • Age of symptom onset in young children with pervasive developmental disorders
    • Rogers SJ, Di Lalla D: Age of symptom onset in young children with pervasive developmental disorders. J Am Acad Child Adolesc Psychiatry 1990, 29:863-872.
    • (1990) J Am Acad Child Adolesc Psychiatry , vol.29 , pp. 863-872
    • Rogers, S.J.1    Di Lalla, D.2
  • 9
    • 0026464821 scopus 로고
    • Can autism be detected at 18 months? The needle, the haystack, and the CHAT
    • Baron-Cohen S, Allen J, Gillberg C: Can autism be detected at 18 months? The needle, the haystack, and the CHAT. Br J Psychiatry 1992, 161:839-843.
    • (1992) Br J Psychiatry , vol.161 , pp. 839-843
    • Baron-Cohen, S.1    Allen, J.2    Gillberg, C.3
  • 10
    • 0007224044 scopus 로고    scopus 로고
    • Case study of the development of an infant with autism from birth to two years of age
    • Dawson G, Osterling J, Meltzoff AN, Kuhl P: Case study of the development of an infant with autism from birth to two years of age. J Appl Dev Psychol 2000, 21:299-313.
    • (2000) J Appl Dev Psychol , vol.21 , pp. 299-313
    • Dawson, G.1    Osterling, J.2    Meltzoff, A.N.3    Kuhl, P.4
  • 11
    • 0002606620 scopus 로고    scopus 로고
    • Diagnosis of autism spectrum disorders in young children
    • Edited by Wetherby A, Prizant B, Paul H. Brookes Publishing Co
    • Lord C, Risi S: Diagnosis of autism spectrum disorders in young children. In Autism Spectrum Disorders: A Transactional Developmental Perspective. Edited by Wetherby A, Prizant B, Paul H. Brookes Publishing Co; 2000:167-190.
    • (2000) Autism Spectrum Disorders: A Transactional Developmental Perspective , pp. 167-190
    • Lord, C.1    Risi, S.2
  • 14
    • 0036677965 scopus 로고    scopus 로고
    • Cerebral lobes in autism: Early hyperplasia and abnormal age effects
    • Carper RA, Moses P, Tigue ZD, Courchesne E: Cerebral lobes in autism: early hyperplasia and abnormal age effects. Neuroimage 2002, 16:1038-1051.
    • (2002) Neuroimage , vol.16 , pp. 1038-1051
    • Carper, R.A.1    Moses, P.2    Tigue, Z.D.3    Courchesne, E.4
  • 15
    • 11844251366 scopus 로고    scopus 로고
    • Localized enlargement of the frontal lobe in autism
    • Carper R, Courchesne E: Localized enlargement of the frontal lobe in autism, Biol Psychiatry 2005, 57:126-133. This study demonstrated that in autism, overgrowth within the frontal lobes is localized to dorsal and mesial regions by early childhood. In autism, this early regionally localized frontal overgrowth is followed by abnormally slow frontal growth, whereas in normal children, frontal growth continues at a robust pace throughout childhood (autism versus normal: 10% versus 48% increase in frontal volumes between 2 and 9 years of age). Combined with past data, the authors conclude that early overgrowth might be more marked in later developing association cortices than in early developing lower-level systems.
    • (2005) Biol Psychiatry , vol.57 , pp. 126-133
    • Carper, R.1    Courchesne, E.2
  • 18
    • 11144230769 scopus 로고    scopus 로고
    • Neuroglial activation and neuroinflammation in the brain of patients with autism
    • Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA: Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2005, 57:67-81. The authors documented the first direct evidence of immune-mediated mechanisms in the neuropathology of autism. Autopsy tissue from 11 autistic patients was used for immunocytochemistry studies. Results showed active neuroinflammatory processes in frontal cortex, underlying white matter and cerebellum as noted by glial activation patterns. Future therapies for autism might thus involve modifying neuroglia responses in the brain.
    • (2005) Ann Neurol , vol.57 , pp. 67-81
    • Vargas, D.L.1    Nascimbene, C.2    Krishnan, C.3    Zimmerman, A.W.4    Pardo, C.A.5
  • 20
    • 0038601952 scopus 로고    scopus 로고
    • Evidence of brain overgrowth in the first year of life in autism
    • th percentile or greater. This study highlights the potential of using changes in HC as a neurobiological early warning sign of autism. The authors suggest a strong need for further study on the causes of abnormal brain growth in autism.
    • (2003) JAMA , vol.290 , pp. 337-344
    • Courchesne, E.1    Carper, R.2    Akshoomoff, N.3
  • 22
    • 16844377433 scopus 로고    scopus 로고
    • Early brain overgrowth in autism: A potential signal of disrupted development of frontal pyramidal neurons and cortical connectivity
    • in press
    • Courchesne E, Pierce K: Early brain overgrowth in autism: a potential signal of disrupted development of frontal pyramidal neurons and cortical connectivity. Int J Dev Neurosci in press.
    • Int J Dev Neurosci
    • Courchesne, E.1    Pierce, K.2
  • 23
    • 1642283099 scopus 로고    scopus 로고
    • Localization of white matter volume increase in autism and developmental language disorder
    • Herbert MR, Ziegler DA, Makris N, Filipek PA, Kemper TL, Normandin JJ, Sanders HA, Kennedy DN, Caviness VS Jr: Localization of white matter volume increase in autism and developmental language disorder. Ann Neurol 2004, 55:530-540. This study further characterizes white matter defects in autism by showing that only the later myelinating outer white matter (called 'radiate' white matter) compartments are enlarged, with deviations from normal being greatest in frontal lobes. Radiate white matter myelinates later than deep white matter and is thus consistent with reports of postnatal brain over-growth in autism. The authors also found a similar pattern of white matter abnormality in developmental language disorder subjects and argue that the underlying pathophysiology might be similar for the two disorders.
    • (2004) Ann Neurol , vol.55 , pp. 530-540
    • Herbert, M.R.1    Ziegler, D.A.2    Makris, N.3    Filipek, P.A.4    Kemper, T.L.5    Normandin, J.J.6    Sanders, H.A.7    Kennedy, D.N.8    Caviness Jr., V.S.9
  • 24
    • 1642441704 scopus 로고    scopus 로고
    • White matter structure in autism: Preliminary evidence from diffusion tensor imaging
    • Barnea-Goraly N, Kwon H, Menon V, Eliez S, Lotspeich L, Reiss AL: White matter structure in autism: preliminary evidence from diffusion tensor imaging, Biol Psychiatry 2004, 55:323-326. Using DTI, the authors found abnormalities in white matter underlying frontal cortices involved in social functioning.
    • (2004) Biol Psychiatry , vol.55 , pp. 323-326
    • Barnea-Goraly, N.1    Kwon, H.2    Menon, V.3    Eliez, S.4    Lotspeich, L.5    Reiss, A.L.6
  • 27
    • 10344231538 scopus 로고    scopus 로고
    • The brain response to personally familiar faces in autism: Findings of fusiform activity and beyond
    • Pierce K, Haist F, Sedaghat F, Courchesne E: The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain 2004, 127:2703-2716. This fMRI study highlights the frontal lobes as a major site of abnormal neurofunctional responding. Although the majority of primary sensory cortices (e.g. visual cortex) showed normal functional responding to faces, there was a notable omission in the medial frontal cortex in the autism group. Furthermore, this study disputes the long held notion that the 'fusiform face area' is deficient in autism and proposes that defects in face processing are the result of influences from abnormalities in other systems, such as attention.
    • (2004) Brain , vol.127 , pp. 2703-2716
    • Pierce, K.1    Haist, F.2    Sedaghat, F.3    Courchesne, E.4
  • 28
    • 1542350319 scopus 로고    scopus 로고
    • Early visual cortex organization in autism: An fMRI study
    • Hadjikhani N, Chabris C, Joseph R, Clark J, McGrath L, Aharon I, Feczko E, Tager-Flusberg H, Harris G: Early visual cortex organization in autism: an fMRI study. Neuroreport 2004, 15:267-270. This functional imaging study provides support for the idea that the neural structures involved in basic visual processing are intact in autism. The authors speculate that abnormalities in visual processing must therefore emerge from defects in top down processing.
    • (2004) Neuroreport , vol.15 , pp. 267-270
    • Hadjikhani, N.1    Chabris, C.2    Joseph, R.3    Clark, J.4    McGrath, L.5    Aharon, I.6    Feczko, E.7    Tager-Flusberg, H.8    Harris, G.9
  • 29
    • 0032810416 scopus 로고    scopus 로고
    • Cerebral correlates of preserved cognitive skills in autism: A functional MRI study of embedded figures task performance
    • Ring HA, Baron-Cohen S, Wheelwright S, Williams SC, Brammer M, Andrew C, Bullmore ET: Cerebral correlates of preserved cognitive skills in autism: a functional MRI study of embedded figures task performance. Brain 1999, 122:1305-1315.
    • (1999) Brain , vol.122 , pp. 1305-1315
    • Ring, H.A.1    Baron-Cohen, S.2    Wheelwright, S.3    Williams, S.C.4    Brammer, M.5    Andrew, C.6    Bullmore, E.T.7
  • 30
    • 0036345757 scopus 로고    scopus 로고
    • Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes
    • Castelli F, Frith C, Happe F, Frith U: Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 2002, 125:1839-1849.
    • (2002) Brain , vol.125 , pp. 1839-1849
    • Castelli, F.1    Frith, C.2    Happe, F.3    Frith, U.4
  • 34
    • 1642403845 scopus 로고    scopus 로고
    • Functional anatomy of impaired selective attention and compensatory processing in autism
    • Belmonte MK, Yurgelun-Todd DA: Functional anatomy of impaired selective attention and compensatory processing in autism. Brain Res Cogn Brain Res 2003, 17:651-664.
    • (2003) Brain Res Cogn Brain Res , vol.17 , pp. 651-664
    • Belmonte, M.K.1    Yurgelun-Todd, D.A.2
  • 35
    • 4043138783 scopus 로고    scopus 로고
    • Cortical activation and synchronization during sentence comprehension in high-functioning autism: Evidence of underconnectivity
    • Just MA, Cherkassky VL, Keller TA, Minshew NJ: Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity. Brain 2004, 127:1811-1821.
    • (2004) Brain , vol.127 , pp. 1811-1821
    • Just, M.A.1    Cherkassky, V.L.2    Keller, T.A.3    Minshew, N.J.4
  • 36
    • 0023922296 scopus 로고
    • The cerebral metabolic landscape in autism, Intercorrelations of regional glucose utilization
    • Horwitz B, Rumsey JM, Grady CL, Rapoport SI: The cerebral metabolic landscape in autism, Intercorrelations of regional glucose utilization. Arch Neurol 1988, 45:749-755.
    • (1988) Arch Neurol , vol.45 , pp. 749-755
    • Horwitz, B.1    Rumsey, J.M.2    Grady, C.L.3    Rapoport, S.I.4
  • 37
    • 84900801479 scopus 로고    scopus 로고
    • White matter volume increase and minicolumns in autism
    • Casanova MF: White matter volume increase and minicolumns in autism. Ann Neurol 2004, 56:453,454.
    • (2004) Ann Neurol , vol.56 , pp. 453
    • Casanova, M.F.1
  • 39
    • 4944227121 scopus 로고    scopus 로고
    • Brain development in autism: Early overgrowth followed by premature arrest of growth
    • Courchesne E: Brain development in autism: early overgrowth followed by premature arrest of growth. Ment Retard Dev Disabil Res Rev 2004, 10:106-111.
    • (2004) Ment Retard Dev Disabil Res Rev , vol.10 , pp. 106-111
    • Courchesne, E.1
  • 41
    • 0036234544 scopus 로고    scopus 로고
    • The minicolumn hypothesis in neuroscience
    • Buxhoeveden DP, Casanova MF: The minicolumn hypothesis in neuroscience. Brain 2002, 125:935-951.
    • (2002) Brain , vol.125 , pp. 935-951
    • Buxhoeveden, D.P.1    Casanova, M.F.2
  • 44
    • 0037131025 scopus 로고    scopus 로고
    • New insights into neuron-glia communication
    • Fields RD, Stevens-Graham B: New insights into neuron-glia communication. Science 2002, 298:556-562.
    • (2002) Science , vol.298 , pp. 556-562
    • Fields, R.D.1    Stevens-Graham, B.2
  • 45
    • 0141533205 scopus 로고    scopus 로고
    • New roles for astrocytes: Redefining the functional architecture of the brain
    • Nedergaard M, Ransom B, Goldman SA: New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 2003, 26:523-530.
    • (2003) Trends Neurosci , vol.26 , pp. 523-530
    • Nedergaard, M.1    Ransom, B.2    Goldman, S.A.3
  • 46
    • 1642344962 scopus 로고    scopus 로고
    • Interlaminar astroglia of the cerebral cortex: A marker of the primate brain
    • Colombo J, Reisin H: Interlaminar astroglia of the cerebral cortex: a marker of the primate brain. Brain Res 2004, 1006:126-131.
    • (2004) Brain Res , vol.1006 , pp. 126-131
    • Colombo, J.1    Reisin, H.2
  • 47
    • 0031420798 scopus 로고    scopus 로고
    • The neural basis of cognitive development: A constructivist manifesto
    • discussion 556-596
    • Quartz SR, Sejnowski TJ: The neural basis of cognitive development: a constructivist manifesto. Behav Brain Sci 1997, 20:537-556. discussion 556-596.
    • (1997) Behav Brain Sci , vol.20 , pp. 537-556
    • Quartz, S.R.1    Sejnowski, T.J.2
  • 48
    • 0032983851 scopus 로고    scopus 로고
    • The constructivist brain
    • Quartz SR: The constructivist brain. Trends Cogn Sci 1999, 3:48-57.
    • (1999) Trends Cogn Sci , vol.3 , pp. 48-57
    • Quartz, S.R.1
  • 50
    • 0242291090 scopus 로고    scopus 로고
    • Model of autism: Increased ratio of excitation/inhibition in key neural systems
    • Rubenstein JL, Merzenich MM: Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav 2003, 2:255-267. The authors describe a model of autism that postulates that some forms of the disorder result from an increased ratio of excitation-inhibition in key neural systems regulating sensory, memory, social and emotional functions.
    • (2003) Genes Brain Behav , vol.2 , pp. 255-267
    • Rubenstein, J.L.1    Merzenich, M.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.