Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability

British Journal of Cancer

Volumn 110, Issue 7, 2014, Pages 1785-1792

  Nishioka, T ^a   Luo, L Y ^b   Shen, L ^a   He, H ^b   Mariyannis, A ^a   Dai, W ^c   Chen, C ^a,d  

^a NORTHEASTERN UNIVERSITY   (United States)

^b NANCHANG UNIVERSITY   (China)

^c NEW YORK UNIVERSITY   (United States)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Akt; Bcl 2; chemoresistance; cisplatin; Keap1; nicotine; ubiquitination

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CISPLATIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; NICOTINE; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; NICOTINIC RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL DEATH; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; APOPTOSIS ASSAY; CELL CULTURE; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG EFFECT; GENETIC TRANSFECTION; PROTEIN INTERACTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CISPLATIN; DRUG RESISTANCE, NEOPLASM; HUMANS; LUNG NEOPLASMS; MICE; NICOTINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; UBIQUITINATION; UP-REGULATION;

EID: 84897572712     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.78     Document Type: Article

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