Aliphatic substitution of o-carboranyl phenols enhances estrogen receptor beta selectivity

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 4, 2014, Pages 386-391

  Ohta, Kiminori ^a   Ogawa, Takumi ^a   Kaise, Asako ^a   Oda, Akifumi ^b   Endo, Yasuyuki ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Carborane; Docking study; Estrogen receptor; Estrogenic activity; Subtype selectivity

Indexed keywords

1,7 BIS (4 METHOXYPHENYL) 9 ALLYL 1,7 DICARBA CLOSO DODECABORANE; 1,7 BIS (4 METHOXYPHENYL) 9 N BUTYL 1,7 DICARBA CLOSO DODECABORANE; 2 CARBORANYL PHENOL DERIVATIVE; 3 CARBORANYL BIS PHENOL DERIVATIVE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HORMONE RECEPTOR AFFECTING AGENT; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; 1-(4-HYDROXYPHENYL)-2-N-PROPYL-1,2-DICARBA-CLOSO-DODECABORANE; BORON DERIVATIVE; ESTROGEN RECEPTOR ALPHA, HUMAN; LIGAND; METHIONINE; PHENOL;

ALKYLATION; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DEMETHYLATION; DRUG SELECTIVITY; DRUG SYNTHESIS; ESTROGEN ACTIVITY; ESTROGEN BINDING; HUMAN; HUMAN CELL; HYDROGENATION; LIGAND BINDING; BINDING COMPETITION; CHEMISTRY; DRUG EFFECTS; MCF 7 CELL LINE; MEDICINAL CHEMISTRY; METABOLISM; MOLECULAR DOCKING; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING, COMPETITIVE; BORON COMPOUNDS; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; LIGANDS; MCF-7 CELLS; METHIONINE; MOLECULAR DOCKING SIMULATION; PHENOL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897541926     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c13-00796     Document Type: Article

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