Novel estrogen receptor (ER) modulators: Carbamate and thiocarbamate derivatives with m-carborane bisphenol structure

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 7958-7963

  Ohta, Kiminori ^a   Ogawa, Takumi ^a   Suzuki, Tomoharu ^b   Ohta, Shigeru ^b   Endo, Yasuyuki ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Bisphenol; Carborane; Estrogen receptor modulator; Structure activity relationship

Indexed keywords

1 (4 CYCLOHEXYLCARBAMOYLOXYPHENYL) 7 (4 HYDROXYPHENYL) 3 CARBORANE; 1 (4 CYCLOHEXYLTHIOCARBAMOYLOXYPHENYL) 7 (4 HYDROXYPHENYL) 3 CARBORANE; 1 (4 ETHYLCARBAMOYLOXYPHENYL) 7 (4 HYDROXYPHENYL) 3 CARBORANE; 1 (4 ISOPROPYLCARBAMOYLOXYPHENYL) 7 (4 HYDROXYPHENYL) 3 CARBORANE; 1 (4 METHYLCARBAMOYLOXYPHENYL) 7 (4 HYDROXYPHENYL) 3 CARBORANE; 1 (4 METHYLTHIOCARBAMOYLOXYPHENYL) 7 (4 HYDROXYPHENYL) 3 CARBORANE; 1 (4 PHENYLCARBAMOYLOXYPHENYL) 7 (4 HYDROXYPHENYL) 3 CARBORANE; CARBAMIC ACID DERIVATIVE; CARBORANE DERIVATIVE; ESTROGEN RECEPTOR ALPHA; SELECTIVE ESTROGEN RECEPTOR MODULATOR; THIOCARBAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; ESTROGEN ACTIVITY; HUMAN; HUMAN CELL; PROTEIN DOMAIN; RECEPTOR AFFINITY;

BINDING, COMPETITIVE; BORANES; BORON COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR MODULATORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PHENOLS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, INFRARED; THIOCARBAMATES;

EID: 71849107576     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.018     Document Type: Article

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