Potent estrogen agonists based on carborane as a hydrophobic skeletal structure: A new medicinal application of boron clusters

Chemistry and Biology

Volumn 8, Issue 4, 2001, Pages 341-355

  Endo, Yasuyuki ^a   Iijima, Toru ^a   Yamakoshi, Yuko ^a   Fukasawa, Hiroshi ^a   Miyaura, Chisato ^b   Inada, Masaki ^b   Kubo, Asako ^c   Itai, Akiko ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c Inst of Medicinal Molecular Design   (Japan)

Author keywords

Carborane; Estrogen ligand; Hydrophobic interaction; Nuclear receptor

Indexed keywords

BORON DERIVATIVE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; LIGAND;

ANIMAL; ARTICLE; BONE DENSITY; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; DRUG POTENTIATION; FEMALE; FEMUR; GENETIC TRANSFECTION; GENETICS; HYDROGEN BOND; METABOLISM; MOUSE; ORGAN SIZE; OSTEOPOROSIS; PATHOLOGY; RAT; REPORTER GENE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRANSACTIVATION; UTERUS; UTERUS DISEASE;

ANIMALS; BONE DENSITY; BORON COMPOUNDS; COS CELLS; DRUG DESIGN; ESTRADIOL; ESTROGENS; FEMALE; FEMUR; GENES, REPORTER; HYDROGEN BONDING; LIGANDS; MICE; MODELS, MOLECULAR; ORGAN SIZE; OSTEOPOROSIS; RATS; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); TRANSFECTION; UTERINE DISEASES; UTERUS;

EID: 0035039049     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00016-3     Document Type: Article

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