Gambogenic acid kills lung cancer cells through aberrant autophagy

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Wang, Mei ^a,b   Chen, Dong ^c   Cheng, Hui ^b   Li, Bin ^c   Yan, Fenggen ^b   Su, Jingjing ^b   Peng, Cheng ^b   Sun, Meiling ^b   Hu, Yawen ^b   Wang, Xiaoshan ^b   Wang, Guanghui ^c   Chen, Zhiwu ^a   Li, Qinglin ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; ANTINEOPLASTIC AGENT; BECLIN 1; CASPASE 3; DANSYLCADAVERINE; GAMBOGENIC ACID; GREEN FLUORESCENT PROTEIN; LC3 PROTEIN; PLANT RESIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTEIN P62; RAPAMYCIN; S6 KINASE; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CANCER THERAPY; CELL DEATH; CELL KILLING; CELL VACUOLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HELA CELL; HUMAN; HUMAN CELL; LUNG CANCER; LYSOSOME; MOUSE; NONHUMAN; PROTEIN DEGRADATION; STAINING; TRADITIONAL MEDICINE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; LUNG NEOPLASMS; LYSOSOMES; MALE; MEMBRANE PROTEINS; MICE; PHAGOSOMES; TERPENES; XANTHONES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84897524945     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083604     Document Type: Article

References (42)

1. Sesen MB, Kadir T, Alcantara RB, Fox J, Brady MS (2012) Survival Prediction and Treatment Recommendation with Bayesian Techniques in Lung Cancer. AMIA Annual Symposium proceedings/AMIA Symposium AMIA Symposium 2012: 838-847.
2. Hwang SH, Yoo MR, Park CH, Jeon TJ, Kim SJ, et al. (2013) Dynamic contrast-enhanced CT to assess metabolic response in patients with advanced non-small cell lung cancer and stable disease after chemotherapy or chemoradiotherapy. European radiology.
3. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917.
4. Cooper S, Spiro SG (2006) Small cell lung cancer: treatment review. Respirology 11: 241-248.
5. Levine B, Yuan J (2005) Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688. (Pubitemid 41434392)
6. Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, et al. (2010) Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24. Cancer Res 70: 3667-3676.
7. Dent P, Yacoub A, Hamed HA, Park MA, Dash R, et al. (2010) The development of MDA-7/IL-24 as a cancer therapeutic. Pharmacology & therapeutics 128: 375-384.
8. Bareford MD, Hamed HA, Tang Y, Cruickshanks N, Burow ME, et al. (2011) Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Autophagy 7: 1261-1262.
9. Bareford MD, Park MA, Yacoub A, Hamed HA, Tang Y, et al. (2011) Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Cancer Res 71: 4955-4967.
10. Zhuang W, Qin Z, Liang Z (2009) The role of autophagy in sensitizing malignant glioma cells to radiation therapy. Acta biochimica et biophysica Sinica 41: 341-351.
11. Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, et al. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126: 121-134. (Pubitemid 44040988)
12. Mizushima N, Levine B (2010) Autophagy in mammalian development and differentiation. Nat Cell Biol 12: 823-830.
13. Thorburn A (2008) Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 13: 1-9.
14. Asano J, Chiba K, Tada M, Yoshii T (1996) Cytotoxic xanthones from Garcinia hanburyi. Phytochemistry 41: 815-820.
15. Lei QM LJ, Gong DE (1985) Experimental study on anticancer activity of gamboge. Chin J Tumor 7: 282.
16. Guo QL, You QD, Wu ZQ, Yuan ST, Zhao L (2004) General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice. Acta Pharmacol Sin 25: 769-774.
17. Qu Bao-Xi HX-G, Li De-Hua (1991) The EXperimental Studies on Antineoplastic Action of Gambogic II. Chinese Journal of Clinical Oncology 18: 50-52.
18. Qu Bao-Xi JY-Z, Zhang Ping, Yu Su-Ping, Li De-Hua (1991) The Cytocidal Kinetic Effects of Gamboge II on L1210 Leukemic Cells. Chinese Journal of Clinical Oncology 18: 53-56.
19. LIU Jing-bing QS-k, LI Jin, (2005) Experimental research of anti-pancreatic cancer with Gambogic Acid. Chinese Clinical Oncology 10.
20. Yang L, Wang M, Cheng H, Li Q (2011) [Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing]. Zhongguo Zhong Yao Za Zhi 36: 1217-1221.
21. Cheng H, Su JJ, Peng JY, Wang M, Wang XC, et al. Gambogenic acid inhibits proliferation of A549 cells through apoptosis inducing through up-regulation of the p38 MAPK cascade. J Asian Nat Prod Res 13: 993-1002.
22. Li Q, Cheng H, Zhu G, Yang L, Zhou A, et al. (2010) Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing and cell cycle arresting. Biol Pharm Bull 33: 415-420.
23. Yan F, Wang M, Li J, Cheng H, Su J, et al. Gambogenic acid induced mitochondrial-dependent apoptosis and referred to Phospho-Erk1/2 and Phospho-p38 MAPK in human hepatoma HepG2 cells. Environ Toxicol Pharmacol 33: 181-190.
24. Yan F, Wang M, Chen H, Su J, Wang X, et al. Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells. Eur J Pharmacol 652: 23-32.
25. Yu XJ, Han QB, Wen ZS, Ma L, Gao J, et al. (2012) Gambogenic acid induces G1 arrest via GSK3beta-dependent cyclin D1 degradation and triggers autophagy in lung cancer cells. Cancer Lett 322: 185-194.
26. Li B, Hu Q, Wang H, Man N, Ren H, et al. (2010) Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death Differ 17: 1773-1784.
27. Munafo DB, Colombo MI (2001) A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J Cell Sci 114: 3619-3629. (Pubitemid 33041044)
28. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676. (Pubitemid 129516338)
29. Chen S, Rehman SK, Zhang W, Wen A, Yao L, et al. (2010) Autophagy is a therapeutic target in anticancer drug resistance. Biochim Biophys Acta 1806: 220-229.
30. Turcotte S, Giaccia AJ (2010) Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol 22: 246-251.
31. Bareford MD, Park MA, Yacoub A, Hamed HA, Tang Y, et al. (2010) Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Cancer Res 71: 4955-4967.
32. Martin AP, Mitchell C, Rahmani M, Nephew KP, Grant S, et al. (2009) Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy. Cancer Biol Ther 8: 2084-2096.
33. Bhutia SK, Das SK, Azab B, Dash R, Su ZZ, et al. (2011) Autophagy switches to apoptosis in prostate cancer cells infected with melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24). Autophagy 7: 1076-1077.
34. Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, et al. (2011) Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 17: 654-666.
35. Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, et al. (2004) Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 11: 448-457. (Pubitemid 38489422)
36. Kanematsu S, Uehara N, Miki H, Yoshizawa K, Kawanaka A, et al. (2010) Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells. Anticancer Res 30: 3381-3390.
37. Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, et al. (2009) Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 119: 1109-1123.
38. Kawaguchi T, Miyazawa K, Moriya S, Ohtomo T, Che XF, et al. (2011) Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress. Int J Oncol 38: 643-654.
39. Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 16: 966-975.
40. Degtyarev M, De Maziere A, Orr C, Lin J, Lee BB, et al. (2008) Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. J Cell Biol 183: 101-116.
41. Bragado P, Armesilla A, Silva A, Porras A (2007) Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis 12: 1733-1742. (Pubitemid 47106882)
42. Maclean KH, Dorsey FC, Cleveland JL, Kastan MB (2008) Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118: 79-88.