Gambogenic acid mediated apoptosis through the mitochondrial oxidative stress and inactivation of Akt signaling pathway in human nasopharyngeal carcinoma CNE-1 cells

European Journal of Pharmacology

Volumn 652, Issue 1-3, 2011, Pages 23-32

  Yan, Fenggen ^a   Wang, Mei ^a   Chen, Hui ^a   Su, Jingjing ^a   Wang, Xiaoshan ^a   Wang, Fei ^a   Xia, Lunzhu ^a   Li, Qinglin ^a  

^a ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Akt; Apoptosis; CNE 1 cells; Gambogenic acid; Mitochondrial oxidative stress

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; CYTOCHROME C; GAMBOGENIC ACID; MESSENGER RNA; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CARCINOMA CELL; CELL DAMAGE; CELL PROLIFERATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR INTERACTION; NASOPHARYNX CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; HUMANS; MITOCHONDRIA; NASOPHARYNGEAL NEOPLASMS; ONCOGENE PROTEIN V-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TERPENES; TUMOR CELLS, CULTURED; XANTHONES;

EID: 78650922868     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.11.018     Document Type: Article

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