Gambogenic acid inhibits proliferation of A549 cells through apoptosis inducing through up-regulation of the p38 MAPK cascade

Journal of Asian Natural Products Research

Volumn 13, Issue 11, 2011, Pages 993-1002

  Cheng, Hui ^a   Su, Jing Jing ^a   Peng, Jian Ya ^b   Wang, Mei ^a   Wang, Xun Cui ^a   Yan, Feng Gen ^a   Wang, Xiao Shan ^a   Li, Qing Lin ^a  

^a ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

A549; Apoptosis; Gambogenic acid; P38 MAPK

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; GAMBOGENIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; HOMEOSTASIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CASPASE 9; CYTOCHROMES C; GARCINIA; HUMANS; IMIDAZOLES; MICE; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; TERPENES; UP-REGULATION; XANTHONES;

GARCINIA; MUS MUSCULUS;

EID: 84862908444     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2011.605062     Document Type: Article

References (23)

1. N.J. Kennedy, C. Cellurale, and R.J. Davis, Cancer Cell 11, 101 (2007).
2. N. Hendrickx, C. Volanti, U. Moens, O.M. Seternes, P. de Witt, J.R. Vandenheede, J. Piette, and P. Agostinis, J. Biol. Chem. 278, 52231 (2003).
3. J.M. Kyriakis and J. Avruch, Physiol. Rev. 81, 807 (2001).
4. M. Mayr, C.H. Li, P. Zou, U. Huemer, Y.H. Hu, and Q.B. Xu, FASEB J. 14, 261 (2000).
5. J.M. Olson and A.R. Hallahan, Trends Mol. Med. 10, 125 (2004).
6. R.L. Keith, Proc. Am. Thorac. Soc. 6, 187 (2009).
7. X.K. Deng, F.Z. Yin, X.Y. Lu, B.C. Cai, and W. Yin, Toxicol Sci. 91, 59 (2006).
8. A. Zhou, Q.L. Li, D.Y. Peng, H.F. Wu, and X.S. Wang, Acta Pharm. Sin. 43, 838 (2008).
9. H.Y. Gu, S.Y. Rao, J. Zhao, J. Wang, R. Mu, J.J. Rong, L. Tao, Q. Qi, Q.D. You, and Q.L. Guo, J. Cancer Res. Clin. Oncol. 135, 1777 (2009).
10. D.Y. Zhai, C.F. Jin, C.W. Shiau, S. Kitada, A.C. Satterthwait, and J.C. Reed, Mol. Cancer Ther. 7, 1639 (2008).
11. P.C. Lu, X. Zhang, H. Yan, and D.J. Ye, Chin. J. Chin. Mater. Med. 21, 280 (1996).
12. G.B. Lu, X.X. Yang, and Q.S. Huang, Acta Pharm. Sin. 19, 636 (1984).
13. Q.L. Li, H. Cheng, G.Q. Zhu, L. Yang, A. Zhou, X.S. Wang, N.B. Fang, L.Z. Xia, J.J. Su, M. Wang, D.Y. Peng, and Q. Xu, Biol. Pharm. Bull. 33, 415 (2010).
14. F.G. Yan, M. Wang, H. Chen, J.J. Su, X.C. Wang, F. Wang, L.Z. Xia, and Q.L. Li, Eur. J. Pharmacol. 652(1-3), 23 (2011).
15. G.P. Anderson, Trends Pharmacol. Sci. 17, 438 (1996).
16. B.J. Kim, S.W. Ryu, and B.J. Song, J. Biol. Chem. 281, 21256 (2006).
17. Y.B. Wang, S. Huang, V.P. Sah, J. Ross Jr, J.H. Brown, J. Han, and K.R. Chien, J. Biol. Chem. 273, 2161 (1998).
18. S. Rousseau, F. Houle, J. Landry, and J. Huot, Oncogene 15, 2169 (1997).
19. H. Cheng, D.Y. Peng, X.S. Wang, L.J. Tang, P. Huang, and Q.L. Li, Chin. Tradit. Herb. Drugs 2, 39 (2008).
20. I. Herr and K.M. Debatin, Blood 98, 2603 (2001).
21. X.S. Liu, C.N. Kim, J. Yang, R. Jemmerson, and X.D. Wang, Cell 86, 147 (1996).
22. N. Zamzami, P. Marchetti, M. Castedo, T. Hirsch, S.A. Susin, B. Masse, and G. Kroemer, FEBS Lett 384, 53 (1996).
23. R.M. Kluck, E. Bossy-Wetzel, D.R. Green, and D.D. Newmeyer, Science 275, 1132 (1997).