Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing

Zhongguo Zhongyao Zazhi

Volumn 36, Issue 9, 2011, Pages 1217-1221

  Yang, Li ^a   Wang, Mei ^a   Cheng, Hui ^a   Li, Qinglin ^a  

^a ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

A549; Apoptosis; GNA; Mechanism

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2; GAMBOGENIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL LINE A549; CELL STRAIN; CONTROLLED STUDY; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; NICK END LABELING; NONHUMAN; NUDE MOUSE; PROTEIN EXPRESSION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOXYGENASE 2; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; TERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XANTHONES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80051543028     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: 10.4268/cjcmm20110923     Document Type: Article

References (16)

1. Wang T T, Wei J, Qian X P, et al. Gambogic acid, a potent inhibitor of surviving, reverses docetaxel resistance in gastric cancer cells[J]. Cancer Lett, 2008,262(2):214.
2. Qinglin L, Hui C, Guoqi Z, et al. Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing and cell cycle arresting[J]. Biol Pharm Bull, 2010,33(3):415.
3. Naiton S. Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organa of mice[J]. Cancer Res, 1986,46:4109.
4. Manders P, Beex L V, Tjan-Heijnen V C, et al. Vascular endothelial growth factor is associated with the efficacy of endocrine therapy in patients with advanced breast carcinoma[J]. Cancer, 2003,98:2125.
5. Stacker S A, Caesar C, Baldwin M E, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics[J]. Nat Med, 2001,7(2):186.
6. Fong K M, Biesterveld E J, Virmani A, et al. FHIT and FRA3B 3p14. 2 allel loss are commin lung cancer and preneo-plastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations [J]. Cancer Res, 1997,57:2256.
7. Leung W K, To K F, Go M Y, et al. Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma[J]. Int J Onpol, 2003,23(5):1317.
8. Williams C S, Tsujii M, Resse J, et al. Host cyclooxygenase-2 modulates carcinoma growth[J]. J Clin Invest, 2000,105(11): 1589.