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Volumn 14, Issue 1, 2014, Pages

MAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells

Author keywords

Epithelial mesenchymal transition (EMT); Lung epithelial cells; Non neuronal cholinergic system; Signaling pathway

Indexed keywords

ACETYLCHOLINE; ALPHA SMOOTH MUSCLE ACTIN; ATROPINE; CARBACHOL; MITOGEN ACTIVATED PROTEIN KINASE; PHYSOSTIGMINE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN; VIMENTIN;

EID: 84897523852     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-14-53     Document Type: Article
Times cited : (25)

References (37)
  • 1
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • 10.1038/sj.onc.1208927, 16123809
    • Zavadil J, Bottinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005, 24:5764-5774. 10.1038/sj.onc.1208927, 16123809.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 2
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • 10.1038/nrm1835, 16493418
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 2006, 7:131-142. 10.1038/nrm1835, 16493418.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 3
    • 84864865828 scopus 로고    scopus 로고
    • EMT and interstitial lung disease: a mysterious relationship
    • 3914631, 22854509
    • Kage H, Borok Z. EMT and interstitial lung disease: a mysterious relationship. Curr Opin Pulm Med 2012, 18:517-523. 3914631, 22854509.
    • (2012) Curr Opin Pulm Med , vol.18 , pp. 517-523
    • Kage, H.1    Borok, Z.2
  • 4
    • 84876282871 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
    • 10.1136/thoraxjnl-2012-201761, 23299965
    • Milara J, Peiró T, Serrano A, Cortiji J. Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke. Thorax 2013, 68:410-420. 10.1136/thoraxjnl-2012-201761, 23299965.
    • (2013) Thorax , vol.68 , pp. 410-420
    • Milara, J.1    Peiró, T.2    Serrano, A.3    Cortiji, J.4
  • 5
    • 84856896936 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma
    • 10.1097/ACI.0b013e32834ec6eb, 22217512
    • Hackett TL. Epithelial-mesenchymal transition in the pathophysiology of airway remodelling in asthma. Curr Opin Allergy Clin Immunol 2012, 12:53-59. 10.1097/ACI.0b013e32834ec6eb, 22217512.
    • (2012) Curr Opin Allergy Clin Immunol , vol.12 , pp. 53-59
    • Hackett, T.L.1
  • 6
    • 84879895194 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition (EMT) in small airways of COPD patients
    • doi:10.1136/thoraxjnl-2013-203373
    • Sohal SS, Walters EH. Epithelial mesenchymal transition (EMT) in small airways of COPD patients. Thorax 2013, 14: . doi:10.1136/thoraxjnl-2013-203373.
    • (2013) Thorax , vol.14
    • Sohal, S.S.1    Walters, E.H.2
  • 7
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • 10.1172/JCI200320530, 297008, 14679171
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003, 112:1776-1784. 10.1172/JCI200320530, 297008, 14679171.
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 8
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention
    • 10.1097/01.ASN.0000106015.29070.E7, 14694152
    • Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004, 15:1-12. 10.1097/01.ASN.0000106015.29070.E7, 14694152.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1-12
    • Liu, Y.1
  • 9
    • 17044453955 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    • 10.1164/ajrccm.163.6.9908135, 11371421
    • Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, Okada Y, Yamasawa F, Nakahara K, Umeda A. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 2001, 163:1476-1483. 10.1164/ajrccm.163.6.9908135, 11371421.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1476-1483
    • Takizawa, H.1    Tanaka, M.2    Takami, K.3    Ohtoshi, T.4    Ito, K.5    Satoh, M.6    Okada, Y.7    Yamasawa, F.8    Nakahara, K.9    Umeda, A.10
  • 10
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • 10.1186/1465-9921-6-56, 1177991, 15946381
    • Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005, 6:56. 10.1186/1465-9921-6-56, 1177991, 15946381.
    • (2005) Respir Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 11
    • 84655175061 scopus 로고    scopus 로고
    • Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
    • Bhattacharyya S, Wei J, Varga J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol 2012, 8:42-54.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 42-54
    • Bhattacharyya, S.1    Wei, J.2    Varga, J.3
  • 12
    • 84857444788 scopus 로고    scopus 로고
    • Aclidinium inhibits human lung fibroblast to myofibroblast transition
    • 10.1136/thoraxjnl-2011-200376, 3282044, 21957094
    • Milara J, Serrano A, Peiró T, Gavaldà A, Miralpeix M, Morcillo EJ, Cortijo J. Aclidinium inhibits human lung fibroblast to myofibroblast transition. Thorax 2012, 67:229-237. 10.1136/thoraxjnl-2011-200376, 3282044, 21957094.
    • (2012) Thorax , vol.67 , pp. 229-237
    • Milara, J.1    Serrano, A.2    Peiró, T.3    Gavaldà, A.4    Miralpeix, M.5    Morcillo, E.J.6    Cortijo, J.7
  • 13
    • 84867190302 scopus 로고    scopus 로고
    • Muscarinic receptor stimulation augments TGF-beta1-induced contractile protein expression by airway smooth muscle cells
    • 10.1152/ajplung.00400.2011, 22865549
    • Oenema TA, Smit M, Smedinga L, Racké K, Halayko AJ, Meurs H, Gosens R. Muscarinic receptor stimulation augments TGF-beta1-induced contractile protein expression by airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2012, 303:L589-L597. 10.1152/ajplung.00400.2011, 22865549.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303
    • Oenema, T.A.1    Smit, M.2    Smedinga, L.3    Racké, K.4    Halayko, A.J.5    Meurs, H.6    Gosens, R.7
  • 14
    • 79952056758 scopus 로고    scopus 로고
    • Tiotropium bromide inhibits TGF-beta-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro
    • 2939683, 20856827
    • Asano K, Shikama Y, Shoji N, Hirano K, Suzaki H, Nakajima H. Tiotropium bromide inhibits TGF-beta-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro. Int J Chron Obstruct Pulmon Dis 2010, 5:277-286. 2939683, 20856827.
    • (2010) Int J Chron Obstruct Pulmon Dis , vol.5 , pp. 277-286
    • Asano, K.1    Shikama, Y.2    Shoji, N.3    Hirano, K.4    Suzaki, H.5    Nakajima, H.6
  • 15
    • 33745218112 scopus 로고    scopus 로고
    • Muscarinic receptor signaling in the pathophysiology of asthma and COPD
    • 10.1186/1465-9921-7-73, 1479816, 16684353
    • Gosens R, Zaagsma J, Meurs H, Halayko AJ. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 2006, 7:73. 10.1186/1465-9921-7-73, 1479816, 16684353.
    • (2006) Respir Res , vol.7 , pp. 73
    • Gosens, R.1    Zaagsma, J.2    Meurs, H.3    Halayko, A.J.4
  • 16
    • 2042443069 scopus 로고    scopus 로고
    • Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells
    • 10.1210/en.2003-1728, 14764638
    • Proskocil BJ, Sekhon HS, Jia Y, Savchenko V, Blakely RD, Lindstrom J, Spindel ER. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology 2004, 145:2498-2506. 10.1210/en.2003-1728, 14764638.
    • (2004) Endocrinology , vol.145 , pp. 2498-2506
    • Proskocil, B.J.1    Sekhon, H.S.2    Jia, Y.3    Savchenko, V.4    Blakely, R.D.5    Lindstrom, J.6    Spindel, E.R.7
  • 17
    • 27644530096 scopus 로고    scopus 로고
    • Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease
    • discussion 311-312, 10.1513/pats.200504-043SR, 16267352
    • Belmonte KE. Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005, 2:297-304. discussion 311-312, 10.1513/pats.200504-043SR, 16267352.
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 297-304
    • Belmonte, K.E.1
  • 18
    • 33845920612 scopus 로고    scopus 로고
    • Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse
    • 10.1385/JMN:30:1:67, 17192631
    • Kummer W, Wiegand S, Akinci S, Schinkel AH, Wess J, Koepsell H, Haberberger RV, Lips KS. Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse. J Mol Neurosci 2006, 30:67-68. 10.1385/JMN:30:1:67, 17192631.
    • (2006) J Mol Neurosci , vol.30 , pp. 67-68
    • Kummer, W.1    Wiegand, S.2    Akinci, S.3    Schinkel, A.H.4    Wess, J.5    Koepsell, H.6    Haberberger, R.V.7    Lips, K.S.8
  • 19
    • 84878802677 scopus 로고    scopus 로고
    • Aclidinium inhibits cigarette smoke-induced lung fibroblast to myofibroblast transition
    • 10.1183/09031936.00017712, 23018909
    • Milara J, Serrano A, Peiró T, Artigues E, Gavaldà A, Miralpeix M, Morcillo EJ, Cortijo J. Aclidinium inhibits cigarette smoke-induced lung fibroblast to myofibroblast transition. Eur Respir J 2013, 41:1264-1274. 10.1183/09031936.00017712, 23018909.
    • (2013) Eur Respir J , vol.41 , pp. 1264-1274
    • Milara, J.1    Serrano, A.2    Peiró, T.3    Artigues, E.4    Gavaldà, A.5    Miralpeix, M.6    Morcillo, E.J.7    Cortijo, J.8
  • 23
    • 84872292839 scopus 로고    scopus 로고
    • TNF-alpha-induced CXCL8 production by A549 cells: involvement of the non-neuronal cholinergic system
    • 10.1016/j.phrs.2012.10.016, 23142559
    • Xu ZP, Devillier P, Xu GN, Zhu L, Zhou W, Hou LN, Tang YB, Yang K, Yu ZH, Chen HZ, Cui YY. TNF-alpha-induced CXCL8 production by A549 cells: involvement of the non-neuronal cholinergic system. Pharmacol Res 2013, 68:16-23. 10.1016/j.phrs.2012.10.016, 23142559.
    • (2013) Pharmacol Res , vol.68 , pp. 16-23
    • Xu, Z.P.1    Devillier, P.2    Xu, G.N.3    Zhu, L.4    Zhou, W.5    Hou, L.N.6    Tang, Y.B.7    Yang, K.8    Yu, Z.H.9    Chen, H.Z.10    Cui, Y.Y.11
  • 24
    • 0028198245 scopus 로고
    • Transforming growth factor beta 1 gene expression in human airways
    • 10.1136/thx.49.3.225, 1021150, 8202878
    • Aubert JD, Dalal BI, Bai TR, Roberts CR, Hayashi S, Hogg JC. Transforming growth factor beta 1 gene expression in human airways. Thorax 1994, 49:225-232. 10.1136/thx.49.3.225, 1021150, 8202878.
    • (1994) Thorax , vol.49 , pp. 225-232
    • Aubert, J.D.1    Dalal, B.I.2    Bai, T.R.3    Roberts, C.R.4    Hayashi, S.5    Hogg, J.C.6
  • 25
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • 10.1073/pnas.0605669103, 1551904, 16924102
    • Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 2006, 103:13180-13185. 10.1073/pnas.0605669103, 1551904, 16924102.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3    Robillard, L.4    Galvez, M.G.5    Brumwell, A.N.6    Sheppard, D.7    Chapman, H.A.8
  • 26
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
    • 10.1016/S0002-9440(10)62351-6, 1606388, 15855634
    • Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM, Borok Z. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 2005, 166:1321-1332. 10.1016/S0002-9440(10)62351-6, 1606388, 15855634.
    • (2005) Am J Pathol , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5    du Bois, R.M.6    Borok, Z.7
  • 27
    • 73949090678 scopus 로고    scopus 로고
    • TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids
    • 10.1186/1465-9921-10-100, 2774671, 19857272
    • Doerner AM, Zuraw BL. TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids. Respir Res 2009, 10:100. 10.1186/1465-9921-10-100, 2774671, 19857272.
    • (2009) Respir Res , vol.10 , pp. 100
    • Doerner, A.M.1    Zuraw, B.L.2
  • 28
    • 34247500507 scopus 로고    scopus 로고
    • New molecular targets for the treatment of neutrophilic diseases
    • 10.1016/j.jaci.2007.01.015, 17353033
    • Barnes PJ. New molecular targets for the treatment of neutrophilic diseases. J Allergy Clin Immunol 2007, 119:1055-1062. 10.1016/j.jaci.2007.01.015, 17353033.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1055-1062
    • Barnes, P.J.1
  • 29
    • 34447289205 scopus 로고    scopus 로고
    • The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?
    • 10.1016/j.pharmthera.2007.05.007, 17597218
    • Gwilt CR, Donnelly LE, Rogers DF. The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?. Pharmacol Ther 2007, 115:208-222. 10.1016/j.pharmthera.2007.05.007, 17597218.
    • (2007) Pharmacol Ther , vol.115 , pp. 208-222
    • Gwilt, C.R.1    Donnelly, L.E.2    Rogers, D.F.3
  • 30
    • 49449094458 scopus 로고    scopus 로고
    • Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans
    • 2518461, 18500366
    • Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol 2008, 154:1558-1571. 2518461, 18500366.
    • (2008) Br J Pharmacol , vol.154 , pp. 1558-1571
    • Wessler, I.1    Kirkpatrick, C.J.2
  • 33
    • 84873170983 scopus 로고    scopus 로고
    • Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target
    • 10.1016/j.pupt.2012.07.003, 22842340
    • Meurs H, Dekkers BG, Maarsingh H, Halayko AJ, Zaagsma J, Gosens R. Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target. Pulm Pharmacol Ther 2013, 26:145-155. 10.1016/j.pupt.2012.07.003, 22842340.
    • (2013) Pulm Pharmacol Ther , vol.26 , pp. 145-155
    • Meurs, H.1    Dekkers, B.G.2    Maarsingh, H.3    Halayko, A.J.4    Zaagsma, J.5    Gosens, R.6
  • 34
    • 0037289743 scopus 로고    scopus 로고
    • Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle
    • 10.1165/rcmb.2002-0128OC, 12540494
    • Gosens R, Nelemans SA, Grootte Bromhaar MM, McKay S, Zaagsma J, Meurs H. Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am J Respir Cell Mol Biol 2003, 28:257-262. 10.1165/rcmb.2002-0128OC, 12540494.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 257-262
    • Gosens, R.1    Nelemans, S.A.2    Grootte Bromhaar, M.M.3    McKay, S.4    Zaagsma, J.5    Meurs, H.6
  • 35
    • 33845621932 scopus 로고    scopus 로고
    • Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G (q/11)
    • 10.1096/fj.05-5622fje, 16723377
    • Kong KC, Billington CK, Gandhi U, Panettieri RA, Penn RB. Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G (q/11). FASEB J 2006, 20:1558-1560. 10.1096/fj.05-5622fje, 16723377.
    • (2006) FASEB J , vol.20 , pp. 1558-1560
    • Kong, K.C.1    Billington, C.K.2    Gandhi, U.3    Panettieri, R.A.4    Penn, R.B.5
  • 37
    • 68549123472 scopus 로고    scopus 로고
    • New regulatory mechanisms of TGF-beta receptor function
    • 10.1016/j.tcb.2009.05.008, 19648010
    • Kang JS, Liu C, Derynck R. New regulatory mechanisms of TGF-beta receptor function. Trends Cell Biol 2009, 19:385-394. 10.1016/j.tcb.2009.05.008, 19648010.
    • (2009) Trends Cell Biol , vol.19 , pp. 385-394
    • Kang, J.S.1    Liu, C.2    Derynck, R.3


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