Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

Bioscience Reports

Volumn 34, Issue 2, 2014, Pages 93-106

  Falk, Matthew D ^a   Liu, Wei ^a   Bolaños, Ben ^a   Unsal Kacmaz, Keziban ^a   Klippel, Anke ^a,b   Grant, Stephan ^a   Brooun, Alexei ^a   Timofeevski, Sergei ^a  

^a PFIZER INC   (United States)

^b CELGENE CORPORATION   (United States)

Author keywords

AGC kinase; Cancer; Kinase inhibitor; Kinetic mechanism; Lipid; Protein kinase N (PKN)

Indexed keywords

ARACHIDONIC ACID; PROTEIN KINASE N; PROTEIN PKN1; PROTEIN PKN2; PROTEIN PKN3; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; ISOENZYME; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME REGULATION; MOLECULAR LIBRARY; PROTEIN EXPRESSION; STEADY STATE; SUICIDE SUBSTRATE; UPREGULATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; KINETICS;

ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; CATALYSIS; HUMANS; ISOENZYMES; KINETICS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS;

EID: 84897495508     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20140010     Document Type: Article

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