Design and synthesis of novel 2H-chromen-2-one derivatives bearing 1,2,3-triazole moiety as lead antimicrobials

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 7, 2014, Pages 1795-1801

  Kushwaha, Khushbu ^a   Kaushik, Nagendra ^b   Lata, L ^a   Jain, Subhash C ^a  

^a UNIVERSITY OF DELHI   (India)

^b Kwangwoon University   (South Korea)

Author keywords

1,2,3 Triazole; 2H Chromen 2 one; Antibacterial activity; Antifungal activity; Click reaction; Cup plate method; Propargyl amines

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 2H CHROMEN 2 ONE DERIVATIVE; AMINE; AMPHOTERICIN B; BROMIDE; CHROMENE DERIVATIVE; CIPROFLOXACIN; FLUCONAZOLE; HETEROCYCLIC AMINE; MICONAZOLE; MORPHOLINE; MOXIFLOXACIN; N ACETYLPIPERAZINE; PIPERAZINE DERIVATIVE; PROPARGYL BROMIDE; PROPARGYLAMINE; UNCLASSIFIED DRUG; 7-(6-(4-(4-ACETYLPIPERAZIN-1-YLMETHYL)-1H-1,2,3-TRIAZOL-1-YL)HEXYLOXY)-4-METHYL-2H-CHROMEN-2-ONE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; COUMARIN DERIVATIVE; TRIAZOLE DERIVATIVE; 4 METHYL 7 [6 [4 (PYRROLIDIN 1 YLMETHYL) 1H 1,2,3 TRIAZOL 1 YL]HEXYLOXY] 2H CHROMEN 2 ONE; 7 (4 AZIDOBUTYLOXY) 4 METHYL 2H CHROMEN 2 ONE; 7 (4 BROMOBUTYLOXY) 4 METHYL 2H CHROMEN 2 ONE; 7 [1 (2 ISOINDOLINE 1,3 DIONE 2 YLETHYL) 1H 1,2,3TRIAZOL 4 YL]METHYLOXY 4 METHYL 2H CHROMEN 2 ONE; AZIDOALKYLOXY 2H CHROMEN 2 ONE DERIVATIVE; N ACETYL PIPERAZINE; PROPARGYLAMINE DERIVATIVE;

ALKYLATION; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; BACILLUS SUBTILIS; BACTERIAL STRAIN; BIOASSAY; CANDIDA ALBICANS; CLICK CHEMISTRY; COMPUTER MODEL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SYNTHESIS; ESCHERICHIA COLI; FUNGAL STRAIN; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MOUSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRACTICE GUIDELINE; PSEUDOMONAS AERUGINOSA; RAT; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; ANIMAL; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DAPHNIA; DOSE RESPONSE; DRUG EFFECTS; FUNGUS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHI;

ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; ESCHERICHIA COLI; FUNGI; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; BACTERIA; COUMARINS; DAPHNIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FUNGI; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84897470576     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.02.027     Document Type: Article

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