Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl) coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site

Journal of Medicinal Chemistry

Volumn 50, Issue 12, 2007, Pages 2886-2895

  Roma, Giorgio ^a   Di Braccio, Mario ^a   Grossi, Giancarlo ^a   Piras, Daniela ^a   Leoncini, Giuliana ^a   Bruzzese, Debora ^a   Signorello, Maria Grazia ^a   Fossa, Paola ^a   Mosti, Luisa ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 (1 PIPERAZINYL)QUINOLIN 2(1H) ONE; 4 (1 PIPERAZINYL) 6 (3 PYRIDYLMETHOXY) 2H 1 BENZOPYRAN 2 ONE; 4 (1 PIPERAZINYL) 7 (3 PYRIDYLMETHOXY) 2H 1 BENZOPYRAN 2 ONE; 4 (4 AMINO 1 PIPERIDINYL) 8 METHYL 7 (3 PYRIDYLMETHOXY) 2H 1 BENZOPYRAN 2 ONE; 7 (ETHOXYMETHOXY) 8 METHYL 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 7 (METHOXYMETHOXY) 8 METHYL 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 7 [(4 METHOXY 3,5 DIMETHYL 2 PYRIDYL)METHOXY] 8 METHYL 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 7 [2 (DIETHYLAMINO)ETHOXY] 8 METHYL 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 7 [2 (DIMETHYLAMINO)ETHOXY] 8 METHYL 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 4 (1 PIPERAZINYL 7 (3 PYRIDYLMETHOXY)COUMARIN; 8 METHYL 4 (1 PIPERAZINYL) 7 [2 (1 PIPERIDINYL)ETHOXY] 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 4 (1 PIPERAZINYL) 7 [2 (1 PYRROLIDINYL)ETHOXY] 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 4 (1 PIPERAZINYL)QUINOLIN 2(1H) ONE; 8 METHYL 7 (2 MORPHOLINOETHOXY) 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 7 (2 PHENOXYETHOXY) 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 7 (2 PHENYLBENZYLOXY) 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 7 [(1 METHYL 3 PIPERIDINYL)METHOXY] 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 7 [(METHYLTHIO)METHOXY] 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; 8 METHYL 7 [2 (METHYLTHIO)ETHOXY] 4 (1 PIPERAZINYL) 2H 1 BENZOPYRAN 2 ONE; ACETYLSALICYLIC ACID; CILOSTAZOL; COUMARIN DERIVATIVE; MILRINONE; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASE III; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; THROMBOCYTE;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; CATALYTIC DOMAIN; COUMARINS; HUMANS; MODELS, MOLECULAR; MORPHOLINES; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PLATELET AGGREGATION INHIBITORS;

EID: 34250879708     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0611511     Document Type: Article

References (23)

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