Discovery of piperidine carboxamide TRPV1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4569-4572

  Cheung, Wing S ^a   Calvo, Raul R ^a   Tounge, Brett A ^a   Zhang, Sui Po ^a   Stone, Dennis R ^a   Brandt, Michael R ^a   Hutchinson, Tasha ^a   Flores, Christopher M ^a   Player, Mark R ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Capsaicin; TRPV1; VR1

Indexed keywords

1 ACETYL 2,3 DIHYDROINDOL 5 YL; 1 ACETYL 2,3 DIHYDROINDOL 6 YL; 1 ACETYL 2,3 DIHYDROINDOL 7 YL; 3 OXO 3,4 DIHYDROBENZO[1,4]OXAZIN 6 YL; AMIDE; INDOL 4 YL; INDOL 5 YL; INDOL 6 YL; PIPERIDINE DERIVATIVE; QUINOLIN 3 YL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANIMAL MODEL; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG POTENCY; HUMAN; NONHUMAN; PAIN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SYNTHESIS;

AMIDES; BENZOXAZINES; CAPSAICIN; CARRIER PROTEINS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PIPERIDINES; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 48849099961     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.035     Document Type: Article

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