miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1

Oncotarget

Volumn 5, Issue 4, 2014, Pages 1083-1090

  Yu, Zuoren ^a,b   Xu, Zengguang ^a   DiSante, Gabriele ^b   Wright, Jennifer ^b   Wang, Min ^b   Li, Yuan ^a   Zhao, Qian ^a   Ren, Tao ^a   Ju, Xiaoming ^b   Gutman, Ellen ^b   Wang, Guangxue ^a   Addya, Sankar ^b   Li, Tieyan ^a   Xiang, Zhendong ^c   Wang, Chenguang ^b   yang, Xiongfei ^c   Yang, Xiaolai ^c   Pestell, Richard G ^b  

^a TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c GANSU PROVINCIAL HOSPITAL   (China)

Author keywords

AKT; Apoptosis; Breast cancer; miR 17 20

Indexed keywords

AKT1 PROTEIN; AKT3 PROTEIN; CYCLIN D1; DOXORUBICIN; MICRORNA; MICRORNA 17; MICRORNA 20; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN P53; TAMOXIFEN; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; AKT1 PROTEIN, MOUSE; MIRN17 MICRORNA, HUMAN; MIRN17 MICRORNA, MOUSE;

3' UNTRANSLATED REGION; ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME DEGRADATION; GENE CLUSTER; GENE EXPRESSION; GENE OVEREXPRESSION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; SENSITIZATION; ULTRAVIOLET IRRADIATION; ANIMAL; BIOSYNTHESIS; BREAST NEOPLASMS; CELL GROWTH; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CELL GROWTH PROCESSES; DOXORUBICIN; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; MICE; MICE, TRANSGENIC; MICRORNAS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84897468938     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1804     Document Type: Article

References (43)

1. Kennedy SG, Kandel ES, Cross TK, Hay N. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol 1999; 19: 5800-10.
2. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. Embo J 1997; 16: 2783-93.
3. Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997; 275: 661-5.
4. Majewski N, Nogueira V, Bhaskar P, et al. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 2004; 16: 819-30.
5. Simpson L, Parsons R. PTEN: life as a tumor suppressor. Exp Cell Res 2001; 264: 29-41.
6. Cheng JQ, Ruggeri B, Klein WM, et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci U S A 1996; 93: 3636-41.
7. Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 1998; 10: 262-7.
8. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 1999; 13: 2905-27.
9. Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005; 8: 179-83.
10. Lee RJ, Albanese C, Fu M, et al. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 2000; 20: 672-83.
11. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001; 3: 245-52.
12. Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 2001; 21: 2203-12.
13. Wilbur DC, Barrows GH. Estrogen and progesterone receptor and c-erbB-2 oncoprotein analysis in pure in situ breast carcinoma: an immunohistochemical study. Mod Pathol 1993; 6: 114-20.
14. Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U. Nuclear export of microRNA precursors. Science 2004; 303: 95-8.
15. Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003; 17: 3011-6.
16. Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W. Single processing center models for human Dicer and bacterial RNase III. Cell 2004; 118: 57-68.
17. Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-5.
18. Cullen BR. Transcription and processing of human microRNA precursors. Mol Cell 2004; 16: 861-5.
19. Lai EC. Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. Nat Genet 2002; 30: 363-4.
20. Krek A, Grun D, Poy MN, et al. Combinatorial microRNA target predictions. Nat Genet 2005; 37: 495-500.
21. Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005; 353: 1793-801.
22. He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature 2005; 435: 828-33.
23. Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122: 6-7.
24. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-66.
25. He L, He X, Lim LP, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007; 447: 1130-4.
26. Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 2004; 101: 2999-3004.
27. Takamizawa J, Konishi H, Yanagisawa K, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004; 64: 3753-6.
28. Johnson SM, Grosshans H, Shingara J, et al. RAS is regulated by the let-7 microRNA family. Cell 2005; 120: 635-47.
29. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002; 99: 15524-15529.
30. Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2005; 102: 13944-9.
31. Eiriksdottir G, Johannesdottir G, Ingvarsson S, et al. Mapping loss of heterozygosity at chromosome 13q: loss at 13q12-q13 is associated with breast tumour progression and poor prognosis. Eur J Cancer 1998; 34: 2076-81.
32. Lin YW, Sheu JC, Liu LY, et al. Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: identification of three independent regions. Eur J Cancer 1999; 35: 1730-4.
33. Yu Z, Wang C, Wang M, et al. A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol 2008; 182: 509-17.
34. Hossain A, Kuo MT, Saunders GF. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 2006; 26: 8191-201.
35. Hayashita Y, Osada H, Tatematsu Y, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 2005; 65: 9628-32.
36. Manfe V, Biskup E, Rosbjerg A, et al. miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma. PLoS One; 7: e29541.
37. Ju X, Katiyar S, Wang C, et al. Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci USA 2007; 104: 7438-43.
38. Zheng A, Kallio A, Harkonen P. Tamoxifen-induced rapid death of MCF-7 breast cancer cells is mediated via extracellularly signal-regulated kinase signaling and can be abrogated by estrogen. Endocrinology 2007; 148: 2764-77.
39. Mandlekar S, Kong AN. Mechanisms of tamoxifen-induced apoptosis. Apoptosis 2001; 6: 469-77.
40. Li Z, Wang C, Jiao X, et al. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 2006; 26: 4240-56.
41. Shan SW, Lee DY, Deng Z, et al. MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. Nat Cell Biol 2009; 11: 1031-8.
42. Yu Z, Willmarth NE, Zhou J, et al. microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci USA 2010; 107: 8231-6.
43. Boehme KA, Kulikov R, Blattner C. p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. Proc Natl Acad Sci U S A 2008; 105: 7785-90.