Loss of heterozygosity at chromosome 13q in hepatocellular carcinoma: Identification of three independent regions

European Journal of Cancer

Volumn 35, Issue 12, 1999, Pages 1730-1734

  Lin, Y W ^b   Sheu, J C ^b   Liu, L Y ^b   Chen, C H ^b   Lee, H S ^b   Huang, G T ^b   Wang, J T ^b   Lee, P H ^a   Lu, F J ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NONE

Author keywords

Chromosome 13q; Hepatocellular carcinoma; Loss of heterozygosity

Indexed keywords

HEPATITIS B SURFACE ANTIGEN;

ARTICLE; CHROMOSOME 13Q; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SUPPRESSOR GENE;

BRCA2 PROTEIN; CARCINOMA, HEPATOCELLULAR; CHROMOSOMES, HUMAN, PAIR 13; FEMALE; HUMANS; LIVER NEOPLASMS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; NEOPLASM PROTEINS; POLYMORPHISM, GENETIC; TRANSCRIPTION FACTORS;

EID: 0033369354     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(99)00205-1     Document Type: Article

References (32)

1. Linsell D.A., Higginson J. The geographic pathology of liver cell cancer. Cameron H.M., Linsell D.A., Warwick G.P. Liver Cell Cancer. 1976;1-16 Elsevier Science, New York.
2. Beasley R.P. Hepatitis B virus as the etiologic agent in hepatocellular carcinoma - epidemiologic considerations. Hepatology. 2:1982;21-26.
3. Chen D.S. Hepatitis B virus infection, its sequelae, and prevention in Taiwan. Okuda K., Ishak K.G. Neoplasms of the Liver. 1987;71-80 Springer, Tokyo.
4. Sheu J.C., Huang G.T., Shih L.N.et al. Hepatitis C and B viruses in hepatitis B surface antigen negative hepatocellular carcinoma. Gastroenterology. 103:1992;1322-1327.
5. Sheu J.C., Huang G.T., Lee P.H.et al. Mutation of p53 gene in hepatocellular carcinoma in Taiwan. Cancer Res. 52:1992;6098-6100.
6. Yeh S.H., Chen P.J., Chen H.L.et al. Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas. Cancer Res. 54:1994;4188-4192.
7. Yeh S.H., Chen P.J., Lai M.Y., Chen D.S. Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma. association with elevated alpha-fetoprotein production Gastroenterology. 110:1996;184-192.
8. Fujimoto Y., Hampton L.L., Wirth P.J., Wang N.J., Xie J.P., Thorgeirsson S.S. Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res. 54:1994;281-285.
9. Urano Y., Watanabe K., Lin C.C.et al. Interstitial chromosomal deletion within 4q11-q13 in a human hepatoma cell line. Cancer Res. 51:1991;1460-1464.
10. Pasquinelli C., Garreau F., Bougueleret L.et al. Rearrangement of a common cellular DNA domain on chromosome 4 in human primary liver tumors. J. Virol. 62:1988;629-632.
11. De Souza A.T., Hankins G.R., Washington M.K., Fine R.L., Orton T.C., Jirtle R.L. Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors. Oncogene. 10:1995;1725-1729.
12. De Souza A.T., Hankins G.R., Washington M.K., Orton T.C., Jirtle R.L. M6p/IGF2R gene is mutated in human hepatocellular carcinoma. Nature Genetics. 11:1995;447-449.
13. Fujiwara Y., Ohata H., Kuroki T.et al. Isolation of a candidate gene on chromosome 8p21.3-22 that is homologous to an extracellular domain of the PDGF receptor beta gene. Oncogene. 10:1995;891-895.
14. Lothe R.A., Fossli T., Danielsen H.E.et al. Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors. J. Natl. Cancer Inst. 84:1992;1100-1108.
15. Zhang X., Xu H.J., Murakami Y.et al. Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma. Cancer Res. 54:1994;4177-4182.
16. Kuroki T., Fujiwara Y., Nakamori S., Imaoka S., Kanematsu T., Nakamura Y. Evidence for the presence of two tumour-suppressor genes for hepatocellular carcinoma on chromosome 13q. Br. J. Cancer. 72:1995;383-385.
17. Wang H.P., Rogler C.E. Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas. Cytogenet. Cell. Genet. 48:1988;72-78.
18. Nose H., Imazeki F., Ohto M.et al. p53 gene mutations and 17p allelic deletions in hepatocellular carcinoma from Japan. Cancer. 72:1993;355-360.
19. Zhang W.D., Hirohashi S., Tsuda H.et al. Frequent loss of heterozygosity on chromosomes 16 and 4 in human hepatocellular carcinoma. Jpn. J. Cancer Res. 81:1990;108-111.
20. Tsuda H., Zhang W.D., Shimosato Y.et al. Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA. 87:1990;6791-6794.
21. Stagle B.L., Zhou Y.-Z., Birchmerier W.et al. Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas. Hepatology. 18:1993;757-762.
22. Nagai H., Pineau P., Tiollais P.et al. Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene. 14:1997;2927-2933.
23. Kim T.M., Benedict W.F., Xu H.J.et al. Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression. Cancer Res. 54:1994;605-609.
24. Friend S.H., Bernards R., Rogelj S.et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 323:1986;643-646.
25. Huang Y., Meltzer S.J., Yin J.et al. Altered messenger RNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas. Cancer Res. 53:1993;1889-1894.
26. Reissmann P.T., Koga H., Takahashi R.et al. Inactivation of the retinoblastoma susceptibility gene in non-small cell lung cancer. Oncogene. 8:1993;1913-1919.
27. Miki Y., Swensen J., Shattuck-Eidens D.et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 266:1994;66-71.
28. Wooster R., Bignell G., Lancaster J.A.et al. Identification of the breast cancer susceptibility gene BRCA2. Nature. 378:1995;789-792.
29. Lin Y.W., Sheu J.C., Huang G.T.et al. Chromosomal abnormality in hepatocellular carcinoma by comparative genomic hybridisation in Taiwan. Eur. J. Cancer. 35:1999;652-658.
30. Dib C., Faure S., Fizames C.et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature. 380:1996;152-154.
31. Wingren S., van den Heuvel A., Gentile M., Olsen K., Hatschek T., Soderkvist P. Frequent allelic losses on chromosome 13q in human male breast carcinomas. Eur. J. Cancer. 33:1997;2393-2396.
32. Ogawara K., Miyakawa A., Shiba M.et al. Allelic loss of chromosome 13q14.3 in human oral cancer correlation with lymph node metastasis. Int. J. Cancer (Pred. Oncol.). 79:1998;312-317.